检索结果-南通市图书馆

Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response

Genes & Diseases 2023年第1期10卷 135-150页

作者： Yuanliang Yan Jinwu Peng Qiuju Liang Xinxin Ren Yuan Cai Bi Peng Xi Chen Xiang Wang Qiaoli Yi Zhijie Xu Department of Pharmacy Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Pathology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Pathology Xiangya Changde HospitalChangdeHunan 415000China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Center for Molecular Medicine Xiangya HospitalKey Laboratory of Molecular Radiation Oncology of Hunan ProvinceCentral South UniversityChangshaHunan 410008China

Several types of modifications have been proven to participate in the metabolism and processing of different RNA types,including non-coding RNAs(ncRNAs).N-6-methyladenosine(m6A)is a dynamic and reversible RNA modification that is closely involved in the ncRNA homeostasis,and serves as a crucial regulator for multiple cancer-associated signaling pathways.The ncRNAs usually regulate the epigenetic modification,mRNA transcription and other biological processes,displaying enormous roles in human cancers.In this review,we summarized the significant implications of m6A-ncRNA interaction in various types of cancers.In particular,the interplay between m6A and ncRNAs in cancer pathogenesis and therapeutic resistance are being widely recognized.We also discussed the relevance of m6A-ncRNA interaction in immune regulation,followed by the interference on cancer immunotherapeutic procedures.In addition,we briefly highlighted the computation tools that could identify the accurate features of m6A methylome among ncRNAs.In summary,this review would pave the way for a better understanding of the biological functions of m6A-ncRNA crosstalk in cancer research and treatment.

关键词： Cancer immune regulation N-6-Methyladenosine Non-coding RNAs Therapeutic response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mannose metabolism and immune regulation:Insights into its therapeutic potential in immunology-related diseases

引用

BIOCELL 2023年第11期47卷 2535-2546页

作者： QINGPAN BU PING LI YUNFEI XIA XINPEI WEI KAI SONG School of Life Sciences Changchun Normal UniversityChangchun130032China

Mannose,a different isomer of the hydroxyl group at the C-2 position of glucose,shares the same transport carrier protein with glucose to enter cells and participate in the regulation of glucose metabolism.It affects cell growth,differentiation,and function and plays an active role in tumor immunity and inflammatory processes.This paper provides theoretical support for expanding the clinical applications of mannose by exploring its constitution,metabolic pathways,and role in regulating immune cell function and treating immunology-related diseases.

关键词： Mannose Metabolism immune cell immune regulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Germinal center kinases in immune regulation

引用

Cellular & Molecular Immunology 2012年第6期9卷 439-445页

作者： Hailei Yin Zhubing Shi ShiJiao Cuicui Chen Wenjia Wang Mark I Greene Zhaocai Zhou Department of Trauma and Orthopaedics General Hospital of Jinan Military RegionJinanChina No.401 Hospital of People Liberation Army QingdaoChina State Key Laboratory of Cell Biology Institute of Biochemistry and Cell BiologyShangha nst tutes for Biological SciencesChinese Academy of SciencesShanghaiChina Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA

Germinal center kinases （GCKs） participate in a variety of signaling pathways needed to regulate cellular functions including apoptosis, cell proliferation, polarity and migration. Recent studies have shown that GCKs are participants in both adaptive and innate immune regulation. However, the differential activation and regulatory mechanisms of GCKs, as well as upstream and downstream signaling molecules, remain to be fully defined. It remains unresolved whether and how GCKs may cross-talk with existing signaling pathways. This review stresses the progresses in research of GCKs relevant to the immune system.

关键词： germinal center kinases immune regulation signal transduction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Functional diversity of long non-coding RNAs in immune regulation

引用

Genes & Diseases 2016年第1期3卷 72-81页

作者： Hua Geng Xiao-Di Tan Center for Intestinal and Liver Inflammation Research Stanley Manne Children’s Research InstituteAnn&Robert H.Lurie Children’s Hospital of ChicagoChicagoIL 60611USA Department of Pediatrics Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Department of Pathology Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA

Precise and dynamic regulation of gene expression is a key feature of immunity.In recent years,rapid advances in transcriptome profiling analysis have led to recognize long noncoding RNAs(lncRNAs)as an additional layer of gene regulation context.In the immune system,lncRNAs are found to be widely expressed in immune cells including monocytes,macrophages,dendritic cells(DC),neutrophils,T cells and B cells during their development,differentiation and activation.However,the functional importance of immune-related lncRNAs is just emerging to be characterized.In this review,we discuss the up-to-date knowledge of lncRNAs in immune regulation.

关键词： immune regulation LncRNAs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Interstitial Chemotherapy with Ricin Temperature-Responsive Gel for Anti-Breast Cancer and immune regulation in Rats

引用

Chinese Journal of Integrative Medicine 2013年第1期19卷 48-53页

作者：陈志奎林礼务蔡晶杨发端蔡华晶薛恩生黄静魏洪芬张秀娟 Ultrasonic Department Affiliated Union Hospital of Fujian Medical University Department of Pathology Affiliated Xiehe Hospital of Fujian Medical University Integrative Medical Institute of Fujian University of Traditional Chinese Medicine Department of Pharmacology College of PharmacyFujian Medical University

Objective： To explore the effect of ricin temperature response gel on breast cancer and its regulatory effect on immune function in rats. Methods： Ricin was purified by chromatography and identified by immunoblotting. The rat subcutaneously transplanted breast cancer model was established. Forty model rats with a tumor diameter of about 3.0 cm were subjected to the study. They were randomized into four groups equally： the model group and three treated groups （blank gel, ricin, ricin-gel） were administered with blank gel, ricin, and ricin temperature response gel via percutaneous intratumor injection, respectively. The tumor was isolated 10 days later for the estimation of tumor inhibition rate （FIR） by weighing, pathologic examination, and detection of tumor apoptosis-associated genes bcl-2 and bax with semiquantitative RT-PCR. Also, peripheral blood was obtained to test T-lymphocyte subsets, the killing function of lymphocytes, and the contents of tumor necrosis factor- oL （TNF- oL ） and interleukin-2 （IL-2）. The outcomes were compared between groups. Results： The TIR in the ricin-gel group was 61.8%, with the pathologic examination showing extensive tumor tissue necrosis. Compared with the model group, after ricin temperature response gel treatment, bcl-2 expression was down- regulated, bax expression was up-regulated, CD4＋ lymphocytes and CD4＋/CD8＋ ratio in peripheral blood were increased, the killing function of lymphocytes was enhanced, and the contents of TNF- α and IL-2 were elevated （P〈0.05 or P〈0.01）. Conclusion： Intratumor injection of ricin temperature-responsive gel showed significant antitumor effect on breast cancer and could enhance the immune function in the tumor-bearing rat.

关键词： ricin gel breast cancer mesenchymal chemotherapy immune regulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

regulation of immune cell responses by semaphorins and their receptors

引用

Cellular & Molecular Immunology 2010年第2期7卷 83-88页

作者： Hyota Takamatsu Tatsusada Okuno Atsushi Kumanogoh Department of Immunopathology Research Institute for Microbial Diseases Osaka University Suita Osaka Japan World Premier International Immunology FrontierResearch Center Osaka University Suita Osaka Japan

Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several members of semaphorins, so-called ＇immune semaphorins＇, are crucially involved in various phases of immune responses. These semaphorins regulate both immune cell interactions and immune cell trafficking during physiological and pathological immune responses. Here, we review the following two functional aspects of semaphorins and their receptors in immune responses： their functions in cell-cell interactions and their involvement in immune cell trafficking.

关键词： semaphorin immune regulation immune cell trafficking tumorigenesis autoimmune diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research Progress of Anti-tumor Effects of Curcuma zedoaria and its Active Ingredients Through immune regulation Mechanism

引用

Journal of Clinical and Nursing Research 2021年第4期5卷 1-7页

作者： Zhuli Hou Gang Fang Department of Medicine Hubei University for NationalitiesEnshi 445000Hubei ProvinceChina Guangxi Key Laboratory of Applied Fundamental Research of Zhuang Medicine Guangxi Traditional Chinese Medical University Nanning 530200Guangxi ProvinceChina

The continuous increase in the incidence rate of various fatal malignant tumors in the recent years warrants an imperative search for medications or drugs with obvious anti-tumor eflects and reliable curative effects.Previous studies have found that Curcuma zedoaria and its active ingredients,such as turmeric oil,curcumol,and P-elemene,have obvious antitumor effects,and they do not have the adverse reactions and side effects seen in the anti-tumor drugs of Western medicine.Based on the review and inductive analysis of related literature,we summarize in the present article the results of some researchers who investigated the anti-tumor effects of Curcuma zedoaria and its active ingredients through the immune regulation mechanism.

关键词： Malignant tumor Curcuma zedoaria and its active ingredients immune regulation Mechanism Anti-tumor effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mesenchymal stem cell-derived exosomes regulate microglia phenotypes:a promising treatment for acute central nervous system injury

引用

Neural Regeneration Research 2023年第8期18卷 1657-1665页

作者： Yu-Yan Liu Yun Li Lu Wang Yan Zhao Rui Yuan Meng-Meng Yang Ying Chen Hao Zhang Fei-Hu Zhou Zhi-Rong Qian Hong-Jun Kang Medical School of Chinese PLA BeijingChina Department of Critical Care Medicine the First Medical CenterChinese PLA General HospitalBeijingChina Beidou Precision Medicine Insititute GuangzhouGuangdong ProvinceChina

There is growing evidence that long-term central nervous system(CNS)inflammation exacerbates secondary deterioration of brain structures and functions and is one of the major determinants of disease outcome and progression.In acute CNS injury,brain microglia are among the first cells to respond and play a critical role in neural repair and regeneration.However,microglial activation can also impede CNS repair and amplify tissue damage,and phenotypic transformation may be responsible for this dual role.Mesenchymal stem cell(MSC)-derived exosomes(Exos)are promising therapeutic agents for the treatment of acute CNS injuries due to their immunomodulatory and regenerative properties.MSC-Exos are nanoscale membrane vesicles that are actively released by cells and are used clinically as circulating biomarkers for disease diagnosis and prognosis.MSC-Exos can be neuroprotective in several acute CNS models,including for stroke and traumatic brain injury,showing great clinical potential.This review summarized the classification of acute CNS injury disorders and discussed the prominent role of microglial activation in acute CNS inflammation and the specific role of MSC-Exos in regulating pro-inflammatory microglia in neuroinflammatory repair following acute CNS injury.Finally,this review explored the potential mechanisms and factors associated with MSCExos in modulating the phenotypic balance of microglia,focusing on the interplay between CNS inflammation,the brain,and injury aspects,with an emphasis on potential strategies and therapeutic interventions for improving functional recovery from early CNS inflammation caused by acute CNS injury.

关键词： acute CNS injury central nervous system inflammation exosome immune regulation mesenchymal stem cell mesenchymal stem cell-derived exosomes(MSC-Exos) microglia activation microglia phenotypic transformation molecular mechanism neuroinflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity in a piglet model

引用

中国科学:生命科学英文版 2023年第9期66卷 2086-2098页

作者： Zhenglin Dong Shuan Liu Qingqing Deng Guanya Li Yulong Tang Xin Wu Dan Wan Yulong Yin Key Laboratory of Agro-Ecological Processes in Subtropical Region Hunan Research Center of Livestock&Poultry SciencesSouth-Central Experimental Station of Animal Nutrition and Feed Science in Ministry of AgricultureInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China

Iron is an essential trace element for both the host and resident microbes in the gut. In this study, iron was administered orally and parenterally to anemic piglets to investigate the role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity. We found that oral iron administration easily increased the abundance of Proteobacteria and Escherichia-Shigella, and decreased the abundance of Lactobacillus in the ileum. Furthermore, similar bacterial changes, namely an increase in Proteobacteria, Escherichia-Shigella, and Fusobacterium and a reduction in the Christensenellaceae_R-7_group,were observed in the colon of both iron-supplemented groups. Spearman's correlation analysis indicated that the changed Fusobacterium, Fusobacteria and Proteobacteria in the colon were positively correlated with hemoglobin, colon and spleen iron levels. Nevertheless, it was found that activated m TOR1 signaling, improved villous height and crypt depth in the ileum,enhanced immune communication, and increased protein expression of IL-22 and IL-10 in the colon of both iron-supplemented groups. In conclusion, the benefits of improved host iron outweigh the risks of altered gut microbiota for intestinal mucosal growth and immune regulation in treating iron deficiency anemia.

关键词： iron deficiency iron-microbial interactions m TOR signaling immune regulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells

引用

Genomics, Proteomics & Bioinformatics 2022年第1期20卷 70-86页

作者： Chen Zhang Xueshuai Han Jingkun Liu Lei Chen Ying Lei Kunying Chen Jia Si Tian-yi Wang Hui Zhou Xiaoyun Zhao Xiaohui Zhang Yihua An Yueying Li Qian-Fei Wang CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Medical Experimental Center Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266035China Qingdao Key Lab of Mitochondrial Medicine Qingdao 266035China International Department Liangxiang CampusBeijing University of Chinese MedicineBeijing 102401China Yihua Biotechnology Co. Ltd.Beijing 100041China Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Department of Functional Neurosurgery Third Medical CenterGeneral Hospital of Chinese PLABeijing 100039China

Ex vivo-expanded mesenchymal stem cells(MSCs)have been demonstrated to be a heterogeneous mixture of cells exhibiting varying proliferative,multipotential,and immunomodulatory capacities.However,the exact characteristics of MSCs remain largely unknown.By singlecell RNA sequencing of 61,296 MSCs derived from bone marrow and Wharton’s jelly,we revealed five distinct subpopulations.The developmental trajectory of these five MSC subpopulations was mapped,revealing a differentiation path from stem-like active proliferative cells(APCs)to multipotent progenitor cells,followed by branching into two paths:1)unipotent preadipocytes or 2)bipotent prechondro-osteoblasts that were subsequently differentiated into unipotent prechondrocytes.The stem-like APCs,expressing the perivascular mesodermal progenitor markers CSPG4/MCAM/NES,uniquely exhibited strong proliferation and stemness signatures.Remarkably,the prechondrocyte subpopulation specifically expressed immunomodulatory genes and was able to suppress activated CD3^(+T) cell proliferation in vitro,supporting the role of this population in immunoregulation.In summary,our analysis mapped the heterogeneous subpopulations of MSCs and identified two subpopulations with potential functions in self-renewal and immunoregulation.Our findings advance the definition of MSCs by identifying the specific functions of their heterogeneous cellular composition,allowing for more specific and effective MSC application through the purification of their functional subpopulations.

关键词： Mesenchymal stem cell Single-cell RNA sequencing Heterogeneity Lineage trajectory immune regulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：