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immune infiltration-associated serum amyloid A1 predicts favorable prognosis for hepatocellular carcinoma

World Journal of Gastroenterology 2020年第35期26卷 5287-5301页

作者： Wei Zhang Hui-Fang Kong Xu-Dong Gao Zheng Dong Ying Lu Jia-Gan Huang Hong Li Yong-Ping Yang Center for Diagnosis and Research of Liver Tumor Fifth Medical Center of People's Liberation Army General HospitalBeijing 100191China Department of Infectious Diseases the Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina

BACKGROUND Serum amyloid A1(SAA1)is an acute-phase protein involved in acute or chronic *** function is still *** addition,the effect of the expression of SAA1 and its molecular function on the progression in hepatocellular carcinoma(HCC)is still *** To demonstrate the expression of SAA1 and its effect on the prognosis in HCC and explain further the correlation of SAA1 and immunity *** SAA1 expression in HCC was conducted with The Cancer Genome Atlas-Liver Hepatocellular Carcinoma(TCGA-LIHC)in GEPIA tool,and the survival analysis based on the SAA1 expression level was achieved in the Kaplan-Meier *** high or low expression group was then drawn based on the median level of SAA1 *** correlation of SAA1 and the clinical features were conducted in the UALCAN web-based portal with TCGA-LIHC,including tumor grade,patient disease stage,and the TP53 *** correlation analysis between SAA1 expression and TP53 mutation was subjected to the TCGA *** tumor purity score and the immune score were analyzed with *** correlation of SAA1 expression and tumor-infiltrating lymphocytes was achieved in TISIDB web-based integrated repository portal for tumor-immune system ***125336 dataset was used to test the SAA1 expression in the responsive or resistant group with anti-PD1 *** set enrichment analysis was applied to evaluate the gene enrichment signaling pathway in *** similar genes of SAA1 in HCC were identified in GEPIA,and the proteinprotein interaction of SAA1 was conducted in the Metascape *** expression of C-X-C motif chemokine ligand 2,C-C motif chemokine ligand 23,and complement C5a receptor 1 was studied and overall survival analysis in HCC was conducted in GEPIA and Kaplan-Meier portal,*** SAA1 expression was decreased in HCC,and lower SAA1 expression predicted poorer overall survival,progression-free survival,and disease-specific ***

关键词： Serum amyloid A1 Hepatocellular carcinoma Low expression Prognosis Hepatitis immune pathways

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Decoding exercise-induced atomic components and prognostic shifts in endometrial carcinoma through differentially expressed genes

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Traditional Medicine Research 2024年第11期9卷 51-64页

作者： Yan Li Zhuo Wang Hai-Ning Li Yuan-Yuan Yong Min Kong Ngenzi Richard Djurist Xin Yang Sana Mushtaq Yan Ma Zhi-Fang Wang Ayang Mba Teresa Yue-Yue Shi Yao He Suo-Fei Li Department of Gynechology General Hospital of Ningxia Medical UniversityYinchuan 750000China Department of Gynechology and Obstetrics Affiliated Beijing Chaoyang Hospital of Capital Medical UniversityBeijing 100020China First Clinical Medical College Ningxia Medical UniversityYinchuan 750000China.

Background:This study aimed to portray the atomic intelligence and prognostic implications of differentially expressed genes and their involvement in biological pathways in endometrial carcinoma,with a specific focus on the impacts of exercise on ***:We utilized a multi-faceted approach,including volcano plots,Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses,Venn diagrams,protein-protein interaction networks,Kaplan-Meier survival analysis,Gene Set Variety Analysis,and single-cell transcriptomic ***,we profiled tumor mutational scenes,assessed the prognostic value of immune-related features,and conducted a comprehensive examination of genetic variations and their impact on tumor mutational burden across different cancer *** genomic interactions and methylation elements were also *** real-time quantitative PCR and immunofluorescence staining,the effects of B-cell lymphoma 2(BCL2)silencing on TNF-αand caspase-3 gene expression were ***:Our study identified a noteworthy number of differentially expressed genes in endometrial carcinoma with potential links to athletic performance ***2 expression levels were found to be associated with survival outcomes,and its changeability across cancers was related to immune cell infiltration and immune checkpoint gene ***-cell investigations uncovered cellular complexity within tumor microenvironments and critical biological pathways in BCL2-overexpressing *** expression flow and mutational effect of BCL2 in endometrial carcinoma were characterized,and the prognostic implications of immune-related features were *** variations,including copy number variations and their relationship with gene expression and tumor mutational burden,were *** genomic transaction highlighted the essential role of regulatory genes in cancer *** of the BCL2 gene signifi

关键词： endometrial carcinoma differentially expressed genes pathway enrichment immune pathways prognostic implications exercise and cancer

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The role of exercise in modulating the HP pathway to reduce glioma-induced epilepsy

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Traditional Medicine Research 2024年第12期9卷 66-74页

作者： Fu-Jun Shi Wei Cai Nan Wu Yang Li Department of Neurosurgery Yinchuan First People’s Hospital Affiliated to Ningxia Medical UniversityYinchuan 750001China Department of Neurosurgery Tianjin Children’s HospitalTianjin 300000China

Background:Glioma-induced refractory epilepsy can be alleviated through conventional exercise,providing a potential therapeutic approach to manage this *** study aims to investigate the underlying ***:Bioinformatics methodologies were employed to scrutinize gene expression data from public repositories such as GEO,with a specific focus on mobility-related genes in *** differential and enrichment analyses,differentially expressed genes(DEGs)were identified,while protein-protein interaction networks elucidated pivotal hub ***:Our analysis revealed 32 DEGs,comprising 23 upregulated and 9 downregulated *** analysis underscored significant alterations in immune pathways in *** central hub genes,haptoglobin(HP)and prostaglandin-endoperoxide synthase 2(PTGS2),were found to be modulated by Arginase 1(ARG1)and Chemokine(C-X-C motif)ligand 8(CXCL8).GSVA analysis associated elevated PTGS2 expression with metabolic pathways,while increased HP expression was correlated with angiogenesis and *** experiments validated HP’s role in tumor cell proliferation,emphasizing its potential as a therapeutic ***:This study highlights the crucial involvement of HP and PTGS2 genes in the etiology of epilepsy,linked to discrepancies in the immune *** findings offer fresh perspectives on the management of epilepsy,emphasizing the neuroprotective possibilities of targeting specific gene pathway.

关键词： epilepsy gene expression bioinformatics immune pathways protein-protein interaction hub genes

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