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MUTYH is a potential prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma

Liver Research 2022年第4期6卷 258-268页

作者： Fan Yang Qinghai Lian Beibei Ni Xiusheng Qiu Yizhan He Xiaoguang Zou Fangping He Wenjie Chen Biotherapy Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Infectious Diseases The First People's Hospital of KashiKashiXinjiangChina Xinjiang Medical University UrumqiXinjiangChina Cell-gene Therapy Translational Medicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Hepatobiliary and Pancreatic Surgery The Eighth Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdongChina

Background:Hepatocellular carcinoma(HCC)is a leading cause of cancer-related death *** development of biomarkers for early detection and monitoring of HCC has not shown significant ***,the second adenomatous polyposis-related gene,MUTYH,which encodes a DNA gly-cosylase,has been observed in its contribution to oxidative DNA damage *** expression of MUTYH can reduce cell survival ***,this study investigated the usefulness of MUTYH in diagnosing and prognosis *** and methods:Using The Cancer Genome Atlas(TCGA)data,we analyzed the prognostic value of MUTYH in *** used logistic regression,Wilcoxon signed-rank test,and KruskaleWallis test to examine MUTYH expression concerning clinical-pathologic *** and multivariate Cox regression methods and Kaplan-Meier analysis were applied to determine the related prognostic factors of *** enrichment analysis(GSEA)was used to determine the critical pathways associated with *** single-sample gene set enrichment analysis(ssGSEA)was conducted to examine the correlation between MUTYH expression and cancer immune ***:The higher expression of MUTYH in HCC patients was associated with a poorer overall survival rate and a shorter disease-specific survival *** Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis showed that all differentially expressed genes(DEGs)between the high and low expression levels of MUTYH significantly enriched in the trace ligand-receptor interaction,cell cycle,oocyte meiosis,gap junction,and DNA *** analysis revealed the signals of their open *** neuron system,M phase,DNA repair,Rho GTPase effector,and cell cycle checkpoints were significantly *** showed a positive correlation between MUTYH expression and the infiltration levels of Th2 cells,NK cells,and T helper ***,a negative correlation was found between MUTYH expression and the infiltration levels of d

关键词： MUTYH Hepatocellular carcinoma(HCC) Bioinformatics Prognostic biomarker immune infiltrates

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Integrated bioinformatics analysis reveals correlations of high TRIM59 expression with worse prognosis and immune infiltrates in lung adenocarcinoma

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Journal of Bio-X Research 2022年第2期5卷 67-80页

作者： Lingge Yang Yuan Wu Liangkun You Binbin Xie Jun Lou Weidong Han Kai Wang Department of Respiratory Medicine The Fourth Affiliated HospitalCollege of MedicineZhejiang UniversityYiwu Department of Medical Oncology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina

Objective:Most patients with advanced lung cancer have a poor *** studies have identified TRIM59 as a novel molecule that serves as a prognostic factor for the progression of non-small cell lung *** the present study,we investigated the role of TRIM59 in predicting the prognosis of lung adenocarcinoma(LUAD)as well as the correlation between TRIM59 expression and immune ***:We analyzed TRIM59 expression in normal and tumor tissues based on RNA-sequencing datasets from The Cancer Genome Atlas and Genotype-Tissue Expression ***-seven cases of LUAD tissues and their matching adjacent tissues were collected,and TRIM59 expression in tissue samples was demonstrated by *** tissue specimens were obtained under the approval of the Medical Ethics Committee of the Second Affiliated Hospital of Zhejiang University School of Medicine(approval ***2019001101;approved on April 3,2019).The immune cell scores were calculated using the CIBERSORT *** Tumor immune Estimation Resource database was used to analyze the correlation between TRIM59 and immune cell ***:TRIM59 was up-regulated in most cancer *** TRIM59 expression predicted a worse prognosis in patients with LUAD(overall survival,P=0.00096;disease-specific survival,P=0.00056;disease-free interval,P=0.0009;progression-free interval,P=0.0012).Moreover,TRIM59 was highly expressed in patients with LUAD who had a poorer ***59 also showed a significant correlation with the ESTIMATE score(P=0.04)and stromal score(P=0.005)in patients with ***,a significant correlation between TRIM59 and the tumor mutation burden was found in LUAD but in no other cancer types(Pimmune cell identification,immune cell infiltrati

关键词： immune checkpoints immune infiltrates lung adenocarcinoma prognosticator TRIM59

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Identification of ANXA1 as a potential prognostic biomarker and correlating with immune infiltrates in colorectal cancer

Identification of ANXA1 as a potential prognostic biomarker ...

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2022第27届广东省药师周大会

作者： Zhikun Liang Xiaoyan Li Department of Pharmacy the Sixth Affiliated HospitalSun Yat-Sen University

Background:ANXA1 is a calcium-dependent phospholipid-binding protein and is frequently associated with inflammation,cell proliferation and ***,the relationship between ANXA1 and the prognosis of multiple tumors and tumor infiltrating immune cells remains ***:Multivariate Cox proportional regression analysis was used for signature genes exploration in the basic of colon adenocarcinoma(COAD) RNA-sequence dataset obtained from TCGA,following the identification of 267 common differentially expressed genes,including ANXA1,among three expression profile datasets(GSE41328,GSE110224 and GSE113513).The differential expression of ANXA1 in different tumors and their corresponding normal tissues were evaluated through the Tumor immune Estimation Resource(TIMER) and Oncomine ***,we investigated the correlation between the expression level of ANXA1 and diverse panel ofinfiltratingimmune cells and their related gene markers in colorectal cancer using correlation analysis in TIMER and GEPIA ***:ThehighexpressionofANXA1 was demonstrated to be closelycorrelatedwithpoorsurvivalinpatients with *** importantly,we found that changes in ANXA1 expression showed a moderate to strong,and statistically significant,correlation with infiltrating levels of B cells,CD8+ T cells,CD4+ T cells,macrophages,neutrophils and dendritic *** contrast,there are only weak correlations between ANXA1 expression and immune cell infiltration in ESCA and ***1 expression was considerably associated with variousimmune markers involving immune cell recruitment,polarization of tumor-associated macrophages,and T cell ***:ANXA1 is not only an independent risk factor in the prediction of theprognosis of colorectal cancer,but also a crucial regulator in immune cell *** study may shed light on the clinical value of ANXA1,especially in the areas of early diagnosisof colorectal cancer and therapeutic target

关键词： Colorectal cancer Differently expressed genes Underlying mechanisms Prediction model immune infiltrates

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NCAPG is a prognostic biomarker and correlated with immune infiltrates in glioma: A study based on TCGA, GEO and CGGA data

NCAPG is a prognostic biomarker and correlated with immune i...

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2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青...

作者： Guangrong Zheng Zhou Yang Jin Wang Zhenyi Wen Hongjin Wang The second hospital of DaLian medical university 海军军医大学第一附属医院大连医科大学附属第二医院

Background: This study aims to provide a new prognostic biomarker of glioma, and to investigate the molecular mechanisms induced by ***: A cohort of 1,131 glioma patients with RNA-seq data from The Cancer Genome Atlas（TCGA project） and Gene Expression Omnibus（GSE4290 and GSE16011 datasets） were analyzed, and the results were well validated in Chinese Glioma Genome Atlas（CGGA project） RNA-seq data of 1,018 gliomas. R language was used as the main tool for statistical analysis and graphical work. The glioma cell lines T98 G and LN-229 were selected. Western blotting and qRT-PCR were used to detect the protein and mRNA expression levels, respectively. An CCK-8 assay was applied for the detection of cell proliferation, while cell scratch test was used to detect the healing ***: NCAPG was highly expressed in glioma tissues with RNA-seq data from TCGA, GEO and CGGA database. Furthermore, the expression of NCAPG could be the independent prognostic *** the growth of tumor grade, NCAPG expression increases significantly, and high NCAPG expression was the predictor of poor overall survival in glioma patients（P ＜ 0.001）. Importantly, when the expression of NCAPG was knockdown, the CCK-8 assay revealed the proliferation of glioma cells（LN-229 and T98 G） decreased significantly in contrast to the vector group. In addition, the healing rates of glioma cells（LN-229 and T98 G） detected by cell scratch test in RNA-si group was significantly lower than the vector group（P＜0.001）. Moreover, the expression of NCAPG has a significantly negative relation in NK cells activated from 22 subpopulations of immune cells by using the CIBERSORT algorithm. Specially, the expression of NCAPG have a positive correlation with MHC-I molecules and ***: The expression of NCAPG is high in glioma, and it can facilitate the proliferation, migration and differentiation of glioma. Meanwhile, NCAPG may inhibit the activation of NK cells by regulating the expression o

关键词： NCAPG glioma immune infiltrates NK cells

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BMI1 overexpression is correlated with a poor prognosis and immune infiltration in hepatocellular carcinoma

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Oncology and Translational Medicine 2024年第2期10卷 60-65页

作者： Min-Cong Wang Peng-Tao Yang Yang Zhang Hong-Bing Ma Department of Radiotherapy Second Affiliated HospitalMedical School of Xi'an Jiaotong UniversityXi'an 710004China

Background:Owing to the occurrence of primary or secondary tolerance,the efficacy of immunotherapy for hepatocellular carcinoma(HCC)patients is ***,the mechanism underlying this tolerance needs to be further investigated.B cell–specific Moloney murine leukemia virus integration site 1(BMI1)is associated with cancer stem cell tumorigenesis,progression,and the maintenance of the ***,the effect of BMI1 expression on immune infiltration and prognosis in HCC is still ***:To assess the relationship between BMI1 expression and HCC prognosis and immune infiltration,the GEPIA database,TIMER database,and K-M plotter were *** database was used to determine the levels ofBMI1 in various tumor tissues and corresponding normal tissues,and examine the association between BMI1 expression and tumor-infiltrating immune *** database was applied to determine BMI1 expression in various tumor tissues and corresponding normal tissues.K-M Plotter was used to study the relationships among BMI1 expression,clinicopathological features,and survival ***:BMI1 expression was markedly higher in various solid tumors compared with that in the respective normal tissues,including HCC,and high expression led to poor relapse-free survival and overall survival in HCC ***1 overexpression was also correlated with the infiltration of immune cells(eg,B cells,CD8+T cells,CD4+T cells,dendritic cells,neutrophils,and macrophages)and positively associated with different subsets of T cells,monocytes,and M1 macrophages,among ***:This study demonstrates that high BMI1 expression is strongly correlated with immune infiltration and poor prognosis in *** expression of BMI1 might thus be a potential mechanism of immune tolerance in this disease.

关键词： BMI1 Hepatocellular carcinoma Prognosis immune infiltrates

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