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CD34^(+)CD38^(-)subpopulation without CD123 and CD44 is responsible for LSC and correlated with imbalance of immune cell subsets in AML

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BIOcell 2022年第1期46卷 159-169页

作者： QIANSHAN TAO QING ZHANG HUIPING WANG HAO XIAO MEI ZHOU LINLIN LIU HUI QIN JIYU WANG FURUN AN ZHIMIN ZHAI YI DONG Department of Hematology The Second Hospital of Anhui Medical UniversityHematology Research CenterAnhui Medical UniversityHefei230601China

Acute myeloid leukemia(AML)is regarded as a stem cell ***,no one unique marker is expressed on leukemia stem cells(LSC)but not on leukemic blasts nor normal hematopoietic stem cells(HSC).CD34^(+)CD38^(-)with or without CD123 or CD44 subpopulations are immunophenotypically defined as putative LSC fractions in ***,markers that can be effectively and simply held responsible for the intrinsical heterogeneity of LSC is still *** the present study,we examined the frequency of three different LSC subtypes(CD34^(+)CD38^(-),CD34^(+)CD38^(-)CD123^(+),CD34^(+)CD38^(-)CD44^(+))in AML at *** then validated their prognostic significance on the relevance of spectral features for diagnostic stratification,immune status,induction therapy response,treatment effect maintenance,and long^(-)term *** our findings,high proportions of the above three different LSC subtypes were all significantly characterized with low complete remission(CR)rate,high relapse/refractory rate,poor overall survival(OS),frequent FLT3^(-)ITD mutation,the high level of regulatory T cells(Treg)and monocytic myeloid^(-)derived suppressor cells(M^(-)MDSC).However,there was no significant statistical difference in all kinds of other clinical performance among the three different LSC *** was demonstrated that CD34^(+)CD38^(-)subpopulation without CD123 and CD44 might be held responsible for LSC and correlated with an imbalance of immune cell subsets in AML.

关键词： Acute myeloid leukemia Leukemia stem cells CD123 CD44 immune cell subsets

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VX-765 reduces neuroinflammation after spinal cord injury in mice

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Neural Regeneration Research 2021年第9期16卷 1836-1847页

作者： Jing Chen Yu-Qing Chen Yu-Jiao Shi Shu-Qin Ding Lin Shen Rui Wang Qi-Yi Wang Cheng Zha Hai Ding Jian-Guo Hu He-Zuo Lü Clinical Laboratory the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui ProvinceChina Anhui Key Laboratory of Tissue Transplantation the First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui ProvinceChina Department of Immunology Bengbu Medical Collegeand Anhui Key Laboratory of Infection and Immunity at Bengbu Medical CollegeBengbuAnhui ProvinceChina

Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal cord. A mouse model of T9 contusive spinal cord injury was established using an Infinite Horizon Impactor, and VX-765, a selective inhibitor of caspase-1, was administered for 7 successive days after spinal cord injury. The results showed that:(1) VX-765 inhibited spinal cord injury-induced caspase-1 activation and interleukin-1β and interleukin-18 secretion.(2) After spinal cord injury, an increase in M1 cells mainly came from local microglia rather than infiltrating macrophages.(3) Pro-inflammatory Th1 Th17 cells were predominant in the Th subsets. VX-765 suppressed total macrophage infiltration, M1 macrophages/microglia, Th1 and Th1 Th17 subset differentiation, and cytotoxic T cells activation;increased M2 microglia;and promoted Th2 and Treg differentiation.(4) VX-765 reduced the fibrotic area, promoted white matter myelination, alleviated motor neuron injury, and improved functional recovery. These findings suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18. This may be a potential strategy for treating spinal cord injury. This study was approved by the Animal Care Ethics Committee of Bengbu Medical College(approval No. 2017-037) on February 23, 2017.

关键词： immune cell subsets immune function inflammasomes leukocyte infiltration macrophages microglia pathways spinal cord injury

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New immune multiobjective optimization algorithm and its application in boiler combustion optimization

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Journal of Southeast University(English Edition) 2010年第4期26卷 563-568页

作者：周霞沈炯沈剑贤李益国东南大学能源与环境学院南京210096

In order to meet the requirements of combustion optimization for saving energy and reducing pollutant emission simultaneously,an immune cell subsets based multiobjective optimization algorithm（ICSMOA）is *** the ICSMOA,the subset division operator and the immunological tolerance operation are *** can be easily addressed by using the subset division operator,and the distribution of the solutions can be guaranteed by the immunological tolerance *** the ICSMOA,a group of Pareto optimal solutions can be ***,by the traditional weighting method（WM）,only one solution can be obtained and it cannot be judged as Pareto optimal or *** contrast to the solutions obtained by the repeatedly performed WM,the simulation results show that most solutions obtained by the ICSMOA are better than the solutions obtained by the *** addition,the Pareto front obtained by the ICSMOA is not as uniform as most classical multiobjective optimization *** optimal solutions which meet the preference set by the decision-maker can be obtained and they are very useful for industrial application.

关键词： combustion optimization multiobjective optimizat-ion immune cell subsets

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