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中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Yuanyuan Liu Ziwei Zhu Yanhong Li Shanzao Chen Li Tong 魏群 Department of Biochemistry and Molecular Biology Gene Engineering and Biotechnology Beijing Key LaboratoryCollege of Life SciencesBeijing Normal University Haikou Qili Pharmaceutical Company Ltd.

Psoriasis is a refractory immune-mediated skin disease,and the discovery of anti-psoriatic drugs with high effectiveness and low toxicity is extremely ***(GCC),an active compound derived from Glycyrrhiza uralensis,has been reported to have good immunosuppressive *** this study,we focused on drug trials in an imiquimod(IMQ)-induced psoriasis-like murine model to evaluate the immunotherapeutic effect of *** injection of 20 mg/kg GCC ameliorated clinical scores and psoriatic symptoms,and strongly reduced the pathological changes due to psoriasis in *** of immune-associated inflammatory cytokine genes was also much *** vitro,GCC significantly inhibited the abnormal proliferation of HaCaT *** indicates that GCC is an effective monomeric compound against psoriasis,and thus a promising candidate for drug development.

关键词： Glycyrol imiquimod-induced psoriasis HaCaT apoptosis cytokine

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imiquimod-induced localized vitiligo in wife and lichen planus in husband

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Chinese Medical Journal 2013年第13期126卷 2593-2593页

作者： Wang Hong-wei Miao Fei Shi Lei Lu Ting Huang Zheng Wang Xiu-li Shanghai Skin Dis Hosp Shanghai 200443 Peoples R China Fudan Univ Huadong Hosp Dept Dermatol Shanghai 200040 Peoples R China

To the editor： The main side effects of topical imiquinaod are dose-dependent application-site reactions. Recently, we founda Chinese couple developed vitiligo-like depigmentation lesions and lichen planus with genital warts after treatment with 5% imiquimod cream, respectively. The wife, 36 years old. was diagnosed with genital warts based on acetic acid white test. Numerous warty lesions were located on both sides of the labia minora and majora, perineal, perianal areas and external cervical orifice. One week after CO2 laser treatment, 5% imiquimod cream （AldaraTM, 3M Pharmaceuticals, USA） was applied to the external genital area every other night to prevent recurrence. Six weeks later, the patient noticed a few spots of slight hypopigmentation at the imiquimod-applied areas and then stopped using the imiquimod cream. But the hypopigmentation gradually became worse and spread to the perineum and perianal areas. Three months later complete depigmentation occurred on the perineum and perianal skin （Figure IA）. Pigment loss in pubic hairs in the imiquimod-applied areas was also visible. The lesions showed clear demarcation lines and did not extend to the areas that had not been treated with imiquimod. The patient had no personal or family history ofvitiligo. She was diagnosed with localized vitiligo. The husband, 37 years old, was also diagnosed with genital warts distributed in the coronal and foreskin areas. One week after the completion of two-session of CO2 laser treatment, 5% imiquimod cream was applied in the same way as his wife for 3 months. One month later, the patient noticed some papular lesions in the imiquimod-applied areas. Three months later, dermatological examination revealed nmltiple purple-red specks （Figure IB）. The patient denied any trauma or history of drug allergy. Histopathological examination revealed hyperkeratosis of the epidermis, local and wedge-type thickening of granular layer, irregular thickening of the cell layer, liquefied degenera

关键词： imiquimod-induced Recently Chinese couple

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Oral Administration of Isogarcinol Ameliorates imiquimod-induced Psoriasis-like Skin Lesions in a Murine Model

Oral Administration of Isogarcinol Ameliorates Imiquimod-ind...

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中国生物化学与分子生物学会2016年全国学术会议

作者： Shanzao Chen Hu Li Juren Cen Yanfang Yang Hezhen Wu Qun Wei Department of Biochemistry and Molecular Biology College of Life Sciences Beijing Normal UniversityGene Engineering and Biotechnology Beijing Key Laboratory College of pharmacy Hubei University of Chinese Medicine

Isogarcinol,a natural compound extracted fromG arciniamangosanaL.,has a significant immunosuppressive effect on systemic lupus erythematosus and rheumatoid *** we demonstrate isogarcinol has thepotentialto ameliorate imiquimodinduced psoriasis-like skin lesions in *** strongly attenuates the aberrant proliferation and differentiation of keratinocytes,

关键词： Isogarcinol imiquimod-induced Psoriasis Immunomodulation

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