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“Dual-Lock-Dual-Key”Controlled Second Near-Infrared Molecular Probe for Specific Discrimination of Orthotopic Colon Cancer and imaging-guided tumor Excision

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CCS Chemistry 2022年第11期4卷 3609-3626页

作者： Kun Dou Chen Fan Wenqi Feng Yao Kong Yunhui Xiang Zijun Wang Zhihong Liu College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072 Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering Hubei UniversityWuhan 430062

Fluorescence imaging in the second infrared window(1000-1700 nm)has emerged as a promising approach to tumor ***,the currently available second near-infrared(NIR-II)imaging agents are based on the“always on”modality or single biomarker activation,which are subject to limited imaging contrast,nonspecific response,and even false-positive ***,we developed a H2S/H+dual-stimuli responsive NIR-II fluorescent probe,WH-N3,for precise tumor delimitation and intraoperative fluorescence-guided surgical ***-N3 itself is nonfluorescent,and it can only light up through synergistic activation by H2S and in the tumor acidic environment(TEM).Such a“duallock-dual-key”strategy-based activatable probe exhibited significantly higher tumor-to-normal tissue(T/N)ratios than the“always on”agent(ICG)and single parameter responsive counterpart probes in the imaging of colon tumors,which overexpresses ***-N3 was also able to visualize the tumor-derived endogenous H2S fluctuation and accurately differentiate tumor types based on H2S content *** excitingly,under the guidance of the probe’s highly specific NIR-II fluorescence,a tiny orthotopic colon tumor with diameter down to 0.8 mm was facilely *** expect our dual-stimuli responsive strategy will contribute more reliable tools for specific discrimination and imaging-guided excision of tumor.

关键词： NIR-II fluorescence dual-stimuli responsive activatable probe orthotopic colon cancer imaging-guided tumor resection

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