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Portal hypertension: Imaging of portosystemic collateral pathways and associated image-guided therapy

World Journal of Gastroenterology 2017年第10期23卷 1735-1746页

作者： Murad Feroz Bandali Anirudh Mirakhur Edward Wolfgang Lee Mollie Clarke Ferris David James Sadler Robin Ritchie Gray Jason Kam Wong Department of Radiology Foothills Medical Centre University of Calgary Division of Interventional Radiology Department of Radiology UCLA Medical Center

Portal hypertension is a common clinical syndrome, defined by a pathologic increase in the portal venous pressure. Increased resistance to portal blood flow, the primary factor in the pathophysiology of portal hypertension, is in part due to morphological changes occurring in chronic liver diseases. This results in rerouting of blood flow away from the liver through collateral pathways to low-pressure systemic veins. Through a variety of computed tomographic, sonographic, magnetic resonance imaging and angiographic examples, this article discusses the appearances and prevalence of both common and less common portosystemic collateral channels in the thorax and abdomen. A brief overview of established interventional radiologic techniques for treatment of portal hypertension will also be provided. Awareness of the various imaging manifestations of portal hypertension can be helpful for assessing overall prognosis and planning proper management.

关键词： Portal hypertension Diagnostic imaging Portosystemic collaterals image-guided therapy

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Small-Molecule Fluorophores for Near-Infrared IIb Imaging and imageguided therapy of Vascular Diseases

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CCS Chemistry 2022年第12期4卷 3735-3750页

作者： Yang Li Hua Zhu Xiaobo Wang Yan Cui Lijuan Gu Xiaowen Hou Mengting Guan Junzhu Wu Yuling Xiao Xiaoxing Xiong Xianli Meng Xuechuan Hong Department of Neurosurgery Renmin Hospital of Wuhan UniversityState Key Laboratory of VirologyWuhan University School of Pharmaceutical SciencesWuhan 430060 State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137 College of Science Research Center for EcologyLaboratory of Extreme Environmental Biological Resources and Adaptive EvolutionInnovation Center for Traditional Tibetan Medicine Modernization and Quality ControlMedical CollegeTibet UniversityLhasa 850000 Center for Experimental Basic Medical Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE)Hubei Provincial Key Laboratory of Developmentally Originated DiseaseHubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsWuhan 430071 Shenzhen Institute of Wuhan University Shenzhen 518057

Accurate and dynamic visualization of vascular diseases can contribute to restraining further deterioration from diseases in a timely ***,visualization is still unable to precisely determine whether and to what extent blood vessels or brain tissues are ***,we report novel benzobis(1,2,5-thiadiazole)-based second near-infrared region(NIR-II)fluorophores HY1-HY4 with highly twisted structures(55°at the S_(0) state),extremely strong aggregation-induced emission(AIE)characteristics(I/I_(0)>13),and remarkably high fluorescence quantum yields(QYs)(up to 14.45%)in the NIR-II region(>1000 nm)and∼0.27%in the nearinfrared IIb window(NIR-IIb,>1500 nm)in aqueous *** NIR-IIb AIE HY4 dots,high-resolution NIR-IIb fluorescence imaging of revascularization and thrombolysis,and real-time feedback of the therapeutic efficacy of Chinese medicine Dengzhan Xixin injection(DXI)on ischemic stroke,were achieved for the first *** addition,results showed that DXI conferred neuroprotection against cerebral ischemia injury mediated via the angiogenesis *** attractive results provide a new perspective for designing ultrabright NIR-IIb probes for vascular-related phenomena,disease assessment,and precise intraoperative imageguided therapy with a deeper tissue penetration depth and higher resolution.

关键词： aggregation-induced emission NIR-IIb imaging(1500-1700 nm) vascular diseases ischemic stroke image-guided therapy

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Aggregation-Induced Fluorogens in Bio-Detection,Tumor Imaging,and therapy:A Review

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CCS Chemistry 2022年第2期4卷 420-436页

作者： Yekkuni L.Balachandran Xingyu Jiang Shenzhen Key Laboratory of Smart Healthcare Engineering Department of Biomedical EngineeringSouthern University of Science and TechnologyNanshan DistrictShenzhenGuangdong 518055

Aggregation-induced emission(AIE)fluorogens produce strong,stable fluorescence upon aggregation,thus enabling a new frontier in bio-detection,cell imaging,and other biomedical *** this review,we summarize the recent developments of AIE fluorogen design strategy,bio-detection,cell imaging,tumor imaging,vascular imaging,and image-guided tumor *** highlight a section on the microfluidic approach to synthesize AIE nanoparticles(NPs)and current challenges and potentials of AIE NPs.

关键词： aggregation-induced emission NIR AIEgens two-photon AIEgens bio-detection bio-imaging image-guided therapy microfluidics

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