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Characterization of astrocytes and microglial cells in the hippocampal CA1 region after transient focal cerebral ischemia in rats treated with ilexonin A

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Neural Regeneration Research 2020年第1期15卷 78-85页

作者： Ai-Ling Xu Guan-Yi Zheng Hui-Ying Ye Xiao-Dong Chen Qiong Jiang Department of Traditional Chinese Medicine Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Department of Neonatology People’s Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhouFujian ProvinceChina Department of Neurology People’s Hospital of NanpingNanpingFujian ProvinceChina Burns Institute of Fujian Medical University Union Hospital FuzhouFujian ProvinceChina

ilexonin A is a compound isolated from the root of Ilex pubescens,a traditional Chinese *** A has been shown to play a neuroprotective role by regulating the activation of astrocytes and microglia in the peri-infarct area after ***,the effects of ilexonin A on astrocytes and microglia in the infarct-free region of the hippocampal CA1 region remain *** cerebral ischemia models were established by 2-hour occlusion of the middle cerebral artery in *** A(20,40 or 80 mg/kg)was administered immediately after ischemia/*** astrocyte marker glial fibrillary acidic protein,microglia marker Iba-1,neural stem cell marker nestin and inflammation markers were detected by immunohistochemistry and western blot *** levels of tumor necrosis factor-αand interleukin 1βwere determined by enzyme linked immunosorbent assay in the hippocampal CA1 *** were activated immediately in progressively increasing numbers from 1,3,to 7 days post-ischemia/*** number of activated astrocytes further increased in the hippocampal CA1 region after treatment with ilexonin *** cells remained quiescent after ischemia/reperfusion,but became activated after treatment with ilexonin *** A enhanced nestin expression and reduced the expression of tumor necrosis factor-αand interleukin 1βin the hippocampus post-ischemia/*** results of the present study suggest that ilexonin A has a neuroprotective effect in the hippocampus after ischemia/reperfusion,probably through regulating astrocytes and microglia activation,promoting neuronal stem cell proliferation and reducing the levels of pro-inflammatory *** study was approved by the Animal Ethics Committee of the Fujian Medical University Union Hospital,China.

关键词： astrocytes hippocampal CA1 region ilexonin A microglia middle cerebral artery occlusion neural stem cell neuroprotection transient focal cerebral ischemia

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