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CRP、il-6联合IFN-γ对COPD合并PA感染患者的诊断价值

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西藏医药 2025年第01期 33-35页

作者：王福安肖欣荣王曼雅石狮市总医院检验科

目的分析CRP、il-6联合IFN-γ对COPD合并下呼吸道铜绿假单胞菌感染患者的诊断价值。方法选取我院检验科2021年8月～2023年8月收治的COPD患者150例。根据患者是否发生下呼吸道铜绿假单胞菌感染，分为感染组（n=39）与未感染组（n=111）... 详细信息

目的分析CRP、il-6联合IFN-γ对COPD合并下呼吸道铜绿假单胞菌感染患者的诊断价值。方法选取我院检验科2021年8月～2023年8月收治的COPD患者150例。根据患者是否发生下呼吸道铜绿假单胞菌感染，分为感染组（n=39）与未感染组（n=111）,比较两组一般资料、CRP、il-6、IFN-γ水平，采用Logistic回归分析COPD患者发生下呼吸道铜绿假单胞菌感染的影响因素，采用受试者工作特征（ROC）曲线评估CRP、il-6联合IFN-γ对COPD患者发生下呼吸道铜绿假单胞菌感染的诊断价值。结果多因素结果显示：合并其他慢性疾病、CRP、il-6、IFN-γ是患者发生感染的危险因素（Pil-6、IFN-γ联合预测COPD合并下呼吸道铜绿假单胞菌患者发生感染的AUC为0.888(95%CI:0.813～0.964)，灵敏度为67.3%，特异度为95.5%优于CRP、il-6、IFN-γ各指标单独预测指标0.058(95%CI:0.523～0.750)、0.058(95%CI:0.663～0.892)、0.057(0.667～0.889)。结论合并其他慢性疾病、CRP、il-6、IFN-γ是COPD患者发生下呼吸道铜绿假单胞菌感染的影响因素，且CRP、il-6、IFN-γ针对COPD患者发生下呼吸道铜绿假单胞菌感染具备一定的预测价值，将三者联合应用可有效提高各指标单独应用时的效能。

关键词： CRP il-6 IFN-γ COPD 下呼吸道铜绿假单胞菌感染

维生素AD联合葡萄糖酸锌治疗小儿轮状病毒性肠炎疗效及对血清il-6和INF-γ的影响

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黑龙江医药科学 2025年第1期48卷 47-48,52页

作者：董磊郭爱玲何庆祥安阳市妇幼保健院儿内一科河南安阳455000

目的:探究维生素AD联合葡萄糖酸锌治疗小儿轮状病毒性肠炎疗效及对血清白介素(il)-6和γ干扰素(INF-γ)的影响。方法:选取安阳市妇幼保健院收治的108例轮状病毒性肠炎患儿分为对照组与联合组,每组54例。对照组予以葡萄糖酸锌治疗,联合... 详细信息

目的:探究维生素AD联合葡萄糖酸锌治疗小儿轮状病毒性肠炎疗效及对血清白介素(il)-6和γ干扰素(INF-γ)的影响。方法:选取安阳市妇幼保健院收治的108例轮状病毒性肠炎患儿分为对照组与联合组,每组54例。对照组予以葡萄糖酸锌治疗,联合组在对照组基础上联合维生素AD治疗,均治疗5 d。比较两组临床疗效、症状改善时间、免疫功能指标[免疫球蛋白(Ig)A、IgG、IgM]、炎症指标(il-6、INF-γ)间差异,分析两组用药安全性。结果:联合组总有效率高于对照组(Pil-6、INF-γ水平显著降低,且联合组显著低于对照组(P<0.05);治疗后,两组IgA、IgG、IgM均显著高于治疗前,且联合组均显著高于对照组(P<0.05)。结论:维生素AD联合葡萄糖酸锌治疗小儿轮状病毒性肠炎疗效较单行葡萄糖酸锌治疗效果更佳,可快速缓解症状,且具有用药安全性,其作用机制可能与改善炎症反应,增强免疫功能相关。

关键词：小儿轮状病毒性肠炎维生素AD 葡萄糖酸锌 il-6 INF-γ

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急性心肌梗死合并心力衰竭与il-6、il-8、il-1β水平相关性分析

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河北北方学院学报(自然科学版) 2025年第2期41卷 28-30页

作者：贾慧宇王书旺李海红董越河北北方学院附属第二医院检验科河北张家口075100 张家口宣钢医院河北张家口075000 北京大学第三医院崇礼院区心内科河北张家口076350

目的探讨急性心肌梗死(acute myocardial infarction,AMI)患者细胞因子il-6、il-8、il-1β水平变化的临床意义。方法选取30例急性心肌梗死合并心力衰竭患者为观察组,同期30例急性心肌梗死非心力衰竭患者为对照组。采用多重微球流式免疫... 详细信息

目的探讨急性心肌梗死(acute myocardial infarction,AMI)患者细胞因子il-6、il-8、il-1β水平变化的临床意义。方法选取30例急性心肌梗死合并心力衰竭患者为观察组,同期30例急性心肌梗死非心力衰竭患者为对照组。采用多重微球流式免疫荧光发光法检测il-6、il-8、il-1β水平;酶联免疫法检测NT-proBNP水平。使用彩色多普勒超声显像仪检测左室射血分数(left ventricular ejection fraction,LVEF)、左室收缩末期容积(left ventricular end-systolic volume,LVESV)及左室舒张末期容积(left ventricular end-diastolic volume,LVEDV)。结果观察组患者血浆il-6、NT-proBNP水平高于对照组(Pil-8、il-1β水平组间比较差异无统计学意义(P>0.05);LVEF低于对照组(P0.05)。Spearman相关分析显示,2组患者il-6水平与LVEF呈负相关(r=-0.241,Pil-8、il-1β与NT-proBNP、LVEF及il-6、il-8、il-1β与LVESV、LVEDV间无明显相关(P>0.05)。结论炎症反应在AMI后病情进展中起重要作用,il-6可能参与了AMI后心力衰竭的发展,调整细胞因子水平可能成为治疗AMI后心衰新思路。

关键词：急性心肌梗死 NT-proBNP il-6 心功能

Expression and Diagnostic Value of D-Dimer,CRP,and il-6 in Children with Mycoplasma Pneumonia

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Journal of Clinical and Nursing Research 2025年第1期9卷 139-145页

作者： Yong Peng Aiming Li The First Affiliated Hospital of Shaoyang University Shaoyang 422000Hunan ProvinceChina Jingzhou Hospital Affiliated to Yangtze University Jingzhou 434020Hubei ProvinceChina

Objective: To investigate the expression and diagnostic value of D-dimer, CRP, and il-6 in children with Mycoplasma pneumonia. Methods: A total of 100 children diagnosed with Mycoplasma pneumonia from the pediatric department of the First Affiliated Hospital of Shaoyang University, admitted between November 2023 and June 2024, were selected for the study. According to the severity of the condition, they were divided into two groups: a mild group (50 cases) and a severe group (50 cases). After treatment, they were further divided into an effective group (63 cases) and a non-effective group (37 cases) based on the treatment outcomes, to compare their diagnostic values. Results: The levels of D-dimer, CRP, il-6, length of hospital stay, fever resolution time, cough resolution time, and the time for lung rales to disappear were higher in the severe group than in the mild group (P il-6 in the non-effective group were higher than those in the effective group (P il-6 was higher than the detection rate for each of D-dimer, CRP, and il-6 alone, suggesting that the combined diagnosis had a higher positive detection rate (P il-6, the combined sensitivity, specificity, and accuracy were all higher (P il-6 are closely related to Mycoplasma pneumonia in children and can serve as auxiliary diagnostic tools for Mycoplasma pneumonia in children, offering significant value.

关键词： Mycoplasma pneumonia in children D-dimer CRP il-6

il-6-deficient Mice Are Susceptible to Ethanol-induced Hepatic Steatosis:il-6 Protects against Ethanol-induced Oxidative Stress and Mitochondrial Permeability Transition in the Liver

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Cellular & Molecular Immunology 2004年第3期1卷 205-211页

作者： Osama El-Assal Won-HoKim SvetlanaRadaeva Section on Liver Biology Laboratory of Physiologic StudiesNational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMD 20892USA.

Interleukin-6(il-6)-deficient mice are prone to ethanol-induced apoptosis and steatosis in the liver;however, the underlying mechanism is not fully *** dysfunction caused by oxidative stress is an early event that plays an important role in the pathogenesis of alcoholic liver ***,we hypothesize that the protective role of il-6 in ethanol-induced liver injury is mediated via suppression of ethanol-induced oxidative stress and mitochondrial *** test this hypothesis,we examined the effects of il-6 on ethanol-induced oxidative stress,mitochondrial injury,and energy depletion in the livers of il-6(-/-)mice and hepatocytes from ethanol-fed *** consumption leads to stronger induction of malondialdehyde(MDA) in il-6(-/-)mice compared to wild-type control mice,which can be corrected by administration of *** vitro, il-6 treatment prevents ethanol-mediated induction of reactive oxygen species(ROS),MDA,mitochondrial permeability transition(MPT),and ethanol-mediated depletion of adenosine triphosphate(ATP)in hepatocytes from ethanol-fed *** of il-6 in vivo also reverses ethanol-induced MDA and ATP depletion in ***,il-6 treatment induces metallothionein protein expression,but not superoxide dismutase and glutathione peroxidase in cultured *** conclusion,il-6 protects against ethanol-induced oxidative stress and mitochondrial dysfunction in hepatocytes via induction of metailothionein protein expression,which may account for the protective role of il-6 in alcoholic liver *** & Molecular Immunology.2004;1(3):205-211.

关键词： il-6 alcoholic liver injury oxidative stress mitochondria metallothionein

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il-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of il-2 signaling

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Cellular & Molecular Immunology 2023年第6期20卷 651-665页

作者： Holly Bachus Erin McLaughlin Crystal Lewis Amber M.Papillion Etty N.Benveniste Dave Durell Hill Alexander F.Rosenberg AndréBallesteros-Tato Beatriz León Department of Medicine Division of Clinical Immunology and RheumatologyUniversity of Alabama at BirminghamBirminghamALUSA Department of Microbiology University of Alabama at BirminghamBirminghamALUSA Department of Cell Developmental and Integrative BiologyUniversity of Alabama at BirminghamBirminghamALUSA informatics Institute University of Alabama at BirminghamBirminghamALUSA Alexion Pharmaceuticals Inc.New HavenCTUSA

Defective interleukin-6 (il-6) signaling has been associated with Th2 bias and elevated IgE levels. However, the underlying mechanism by which il-6 prevents the development of Th2-driven diseases remains unknown. Using a model of house dust mite (HDM)-induced Th2 cell differentiation and allergic airway inflammation, we showed that il-6 signaling in allergen-specific T cells was required to prevent Th2 cell differentiation and the subsequent IgE response and allergic inflammation. Th2 cell lineage commitment required strong sustained il-2 signaling. We found that il-6 turned off il-2 signaling during early T-cell activation and thus inhibited Th2 priming. Mechanistically, il-6-driven inhibition of il-2 signaling in responding T cells was mediated by upregulation of Suppressor Of Cytokine Signaling 3 (SOCS3). This mechanism could be mimicked by pharmacological Janus Kinase-1 (JAK1) inhibition. Collectively, our results identify an unrecognized mechanism that prevents the development of unwanted Th2 cell responses and associated diseases and outline potential preventive interventions.

关键词： Th2 cell polarization il-6 il-2 SOCS3 JAK1 inhibitor

Inhibitory Effect of TCCE on CCl4-induced Overexpression of il-6 in Acute Liver Injury

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Acta Biochimica et Biophysica Sinica 2004年第11期36卷 767-772页

作者： Jing GAO, Huan DOU, Xin-Hui TANG, Li-Zhi XU, Yi-Mei FAN, and Xiao-Ning ZHAOSchool of Medicine, School of Life Sciences, Nanjing University, Nanjing 210093, China School of Medicine School of Life Sciences Nanjing UniversityNanjing 210093 China

Terminalia catappa L. leaves have been shown to protect against acute liver injury produced by some hepatotoxicants, but the active components and mechanisms are not clear. This study was designed to characterize the protective effects of the chloroform fraction of the ethanol extract of T. catappa leaves (TCCE) against carbon tetrachloride (CCl4)-induced hepatotoxicity in mice, and analyze the changes in expression level of interleukin-6 (il-6) in the process. It was found that TCCE pretreatment (10 or 30 mg/kg, ig) protected mice from CCl4 toxicity, as evidenced by the reversed alterations in serum alanine aminotrans-ferase (sALT) and serum aspartate aminotransferase (sAST) activities. Additionally liver tissues were subjected to RT-PCR, Western blot and immunohistochemistry to analyze changes in il-6 expression. It was found that TCCE markedly suppressed the CCl4-induced over-transcription of il-6 gene. Consistent with the result, the expression of il-6 protein was also blocked by TCCE in CCl4-stimula

关键词： acute liver injury TCCE CCl4 il-6 expression

KDM2B promotes il-6 production and inflammatory responses through Brg1-mediated chromatin remodeling

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Cellular & Molecular Immunology 2020年第8期17卷 834-842页

作者： Qingqing Zhou Yunkai Zhang Bo Wang Wenhui Zhou Yong Bi Wanwan Huai Xi Chen Yihan Chen Zhongmin Liu Xingguang Liu Zhenzhen Zhan Institute of Heart Failure Shanghai East HospitalTongji University School of Medicine200120ShanghaiChina National Key Laboratory of Medical Immunology&Institute of Immunology Second Military Medical University200433ShanghaiChina Shanghai Fourth People’s Hospital Tongji University School of Medicine200081ShanghaiChina Institute of Immunology Zhejiang University School of Medicine310058HangzhouChina Key Laboratory of Arrhythmias of the Ministry of Education of China Shanghai East HospitalTongji University School of Medicine200120ShanghaiChina

il-6 plays important and pleiotropic roles in infection and inflammatory diseases,and its production needs to be tightly ***,the epigenetic mechanism underlying il6 gene transcription remains to be fully ***,we report that lysine-specific demethylase 2b(KDM2B),which demethylates H3K4me3 and H3K36me2,is required in macrophages and dendritic cells for the induction of il-6 but not TNF-α,il-1,and IFN-β.Compared to wild-type mice,KDM2B-deficient mice were more resistant to endotoxin shock and colitis,with a less severe inflammatory pathogenesis phenotype and decreased il-6 production in ***2B selectively bound the il6 promoter but did not alter histone demethylation;instead,KDM2B interacted with Brahma-related gene 1(Brg1),the core ATPase subunit of SWI/SNF chromatin remodeling complexes,to facilitate chromatin accessibility of the il6 ***,KDM2B directly recruited RNA Polymerase II to further initiate and promote il6 ***,our finding identifies a novel nonclassical function of KDM2B in gene-specific transcription initiation and enhancement of il6 independent of its demethylase activity and adds new insight into the specific epigenetic modification mechanism of inflammatory immune responses.

关键词： KDM2B il-6 Brg1 Chromatin remodeling Inflammation

The Inhibitory Effect of Quercetin on il-6 Production by LPS-Stimulated Neutrophils

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Cellular & Molecular Immunology 2005年第6期2卷 455-460页

作者： Jiajia Liu~(1,2) Xin Li~1 Yang Yue~1 Juan Li~1 Tao He~1 Yanzheng He~1 ~1Laboratory of Molecular Biology,Luzhou Medical College,Luzhou 646000,Sichuan,China ~2Laboratory of Molecular Biology,Luzhou Medical College,Luzhou 646000,Sichuan,China. Laboratory of Molecular Biology Luzhou Medical College Luzhou 646000 Sichuan China.

Quercetin is a herbal flavonoid derived from various foods of plant origin and plays a role in anti-inflammation. Although a number of researches in the field have been done, the mechanism of anti-inflammatory effect of quercetin should be further darified. In the present study, we investigated the effects of quercetin on il-6 production by LPS-stimulated neutrophils in human. Neutrophils were were pre-treated with quercetin at the final concentrations of ranging from 0-80 ~M for 30 rain, or not treated, and then incubated in the presence or absence of lipopolysaccharide （LPS） at a final concentration of 100 ng/ml for indicated time. The secretion level of il-6 in the culture supernatants was assayed by ELISA, the intracellular level of il-6 was detected by flow cytometry and the expression of il-6 mRNA was analyzed by RT-PCR. The experiment results showed that neutrophils cultured with medium or quercetin alone did not express il-6, but LPS （100 ng/ml） induced il-6 expression of neutrophils. However, after pre-treatment of neutrophils with quercetin （40 ~Vl） for 30 rain, the inducible effects of LPS on the increase of il-6 secretion, intracellular il-6 level and il-6 mRNA expression by neutrophils were abrogated. il-6 is one of the important pro-inflammatory factors, especially in early phage of inflammation. Thus, our data suggested that quercetin might exert its anti-inflammatory effect through negatively modulating pro-inflammatory factors, such as il-6. The inhibitory effects of quercetin on il-6 production by neutrophils may provide a theoretical basis on future therapy of inflammation. Cellular ＆ Molecular Immunology. 2005;2（6）：455-460.

关键词： quercetin neutrophil il-6 LPS inflammation

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