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Relation of il-2,il-3 and il-4 with Allergic Asthma Induced by Spores of Mushroom(Pleurotus sapidus)

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Biomedical and Environmental Sciences 1993年第3期6卷 281-285页

作者： LANGWEN－FANG LIDIAN－DONG 等 InstituteofOccupationalMedicine ChineseAcademyofPreventiveMedicineBeijing100050 InstituteofMedicinal

The effects of il-2, il-3, and il-4 activities on occurrence of allergic asthma induced by spores of mushroom have been studied by measuring the il-2, il-3, and il-4 activities in culture supernatants of spleen lymphocytes from guinea pigs being stimulated with Con A. The il-4 activity (14.9±0.18 u) in the culture supernatant was higher than control group (6.7±1.5 u). The il-2 and il-3 activities were all similar to that of the control group. The il-4 synthesis was similarly raised as the il-4 activity. These results indicated that there is a relationship between the occurrence of allergic asthma and the increase of il-4.

关键词： Pleurotus sapidus Relation of il-2,il-3 and il-4 with Allergic Asthma Induced by Spores of Mushroom il

Defective il-4/Stat6 Signaling Correlates with Increased Apoptosis of Human EBV-lymphoblastoid B Cells and Mouse Spleen Cells

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生物医学工程学杂志 2005年第S1期22卷 103-104页

作者： Wen Jie ZHANG~Δ Yun-Feng ZHOU Cong-Hua XIE(Department of Radio-Chemotherapy, Zhongnan Hospital and Cancer Research Center,Wuhan University, Wuhan 430071, China) Department of Radio-Chemotherapy Zhongnan Hospital and Cancer Research Center Wuhan University Wuhan 430071 China

1 Introductionil-4-induced Stat6 (Signal transducer and activator of transcription 6) pathway is active in many cell types including cancer cells and immune cells which plays an important role in cell differenciation/growth and resistance to apoptosis[1]. il-4/Stat6 signaling up-regulates cell surface moleculi suchas CD23, MHC class Ⅱ and il-4Rα, and down-regulates proinflammatory cytokines, i. e,il-12 and TNFα.

关键词： il EBV Defective il-4/Stat6 Signaling Correlates with Increased Apoptosis of Human EBV-lymphoblastoid B Cells and Mouse Spleen Cells

CLINICAL SIGNIFICANCE OF MEASURING SERUM il-6 ACTIVITIES IN MULTIPLE MYELOMA AN ANALYSIS OF 81 CASES

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Chinese Medical Journal 1994年第11期 70-71页

作者：候健孔宪涛

Interleukin 6(il-6) is known as hybridoma cell growth factor,B-cell differentiating factor and so on One of its important biological functions in to induce

关键词： il In CLINICAL SIGNIFICANCE OF MEASURING SERUM il-6 ACTIVITIES IN MULTIPLE MYELOMA AN ANALYSIS OF 81 CASES

Optimal expression of Hh1-like response requires il-4 at early stage of experimental autoimmune uveitis (EAU)

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Acta Pharmacologica Sinica 1999年第5期 85-86页

作者： Rachel R CASPI Bethesda Laboratory of Immunology MD 20892 USA National Eye Institute National Institutes of Health

il-4 is a Th2-type cytokine which plays a major role in determining the Tho-type cell differentiation towards Th2-type

关键词： EAU IRBP il

Dynamic Observation on Regulation of Electroacupuncture on Induction of il-2 Production of Spleen Lymphocytes from Traumatized Rats

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针刺研究 1997年第Z1期 95-96页

Serum il-1β and il-18 correlate with ESR and CRP in multidrug-resistant tuberculosis patients

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The Journal of Biomedical Research 2015年第5期29卷 426-428页

作者： Yanli Wang Chunmei Hu Zailiang Wang Hui Kong Weiping Xie Hong Wang Department of Respiratory Medicine The First Affiliated Hospital of Nanjing Medical University

Dear Editor： The emergence of multidrug-resistant tuberculosis （MDR-TB） is bringing new challenges. MDR-TB is caused by Mycobacterium tuberculosis （M. tuberculosis） that is resistant to isoniazid and rifampicin, with or with- out resistance to other anti-tuberculosis drugs. Approximately 450,000 people developed MDR-TB worldwide in 2012 and an estimated 170,000 people died from the disease. Bacterial burden is not strictly corre- lated with disease progression, and several hallmarks of severe tuberculosis suggest that insufficiently controlled inflammation plays an important role in pathogenesis.

关键词： ESR TB CRP and il-18 correlate with ESR and CRP in multidrug-resistant tuberculosis patients Serum il-1 il MDR

Detection of serum TNF-α,IFN-γ,il-6 and il-8 in patients with hepatitis B

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World Journal of Gastroenterology 1999年第1期5卷 43-45页

作者： WANG Jing Yan, WANG Xue Lian and LIU Pei

ＮＴＲＯＤＵＣＴＩＯＮＳｉｎｃｅＭｕｔｏ［１］ｒｅｐｏｒｔｅｄｔｈａｔＴＮＦαａｎｄＩＬ１ｗｅｒｅｒｅｌａｔｅｄｔｏｆｕｌｍｉｎａｎｔｈｅｐａｔｉｔｉｓ，ｔｈｅｓｔｕｄｉｅｓｏｎｔｈｅｒｅｌａｔｉｏｎｓｈｉｐ... 详细信息

ＮＴＲＯＤＵＣＴＩＯＮＳｉｎｃｅＭｕｔｏ［１］ｒｅｐｏｒｔｅｄｔｈａｔＴＮＦαａｎｄＩＬ１ｗｅｒｅｒｅｌａｔｅｄｔｏｆｕｌｍｉｎａｎｔｈｅｐａｔｉｔｉｓ，ｔｈｅｓｔｕｄｉｅｓｏｎｔｈｅｒｅｌａｔｉｏｎｓｈｉｐｂｅｔｗｅｅｎｃｙｔｏｋｉｎｅｓａ...

关键词： hepatitis B TNF α IFN γ il 6 il 8

REGULATORY EFFECTS OF HUMAN RECOMBINANT il-6 ON NATURAL KilLER CELL ACTIVITY OF HUMAN FETAL SPLEENS

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Chinese Journal of Cancer Research 1991年第1期3卷 38-41页

作者：路力生崔正言田志刚 Department of Immunology Institute of Basic Medical Sciences Shandong Academy of Medical Sciences Jinan Shandong Cancer Biotherapy Centre Jinan

In the present study it was proved first that human recombinant interleukin-6(Hril-6) significantly augmented natural killer(NK) cell activity derived from human fetal spleens against K562 target cells in a 4 hours 51Cr release assay. The enhancement of NK activity with 24 hours preincubation in HrlL-6 was dose-dependent, and significantly higher than that of fresh NK cells and controls cultured with RPMI-1640 medium alone (Pil-6 was able to augment NK activity from different fetal spleens at 20 to 40 weeks of gestation (up to 2.24 to 2.78 times), and no difference of NK activity of fetal splenocytes treated by Hril-6 was observed between different fetal age (32.3% to 45.4%, P>0.05). Furthermore, il-6-augmented NK activity of fetal splenocytes was very similar to adult levels (P>0.05). These finding strongly indicated that il-6 plays an important role in the development of NK cell function during the gestational period, suggesting that il-6 may be of importance in the regulation of host defense mechanisms against malignancies and viral diseases.

关键词： il REGULATORY EFFECTS OF HUMAN RECOMBINANT il-6 ON NATURAL KilLER CELL ACTIVITY OF HUMAN FETAL SPLEENS

Co-modification of il-2-TNFα fusion gene and B7 1 gene to murine breast tumor cells leads to improved tumor rejection and vaccine effect

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Chinese Medical Journal 2000年第2期 71-75页

作者：刘雪丰张连峰张铭马耀文许贤豪蔡有余

Objective To improve the vaccine potency of gene modified tumor cells Methods Using recombinant adenoviruses, we expressed the B7 1 gene in murine breast tumor cell line EMF 6 and a subline previously transfected with retrovirus vector XdF harboring the il 2 TNFα fusion gene Results Immunization/challenge experiments demonstrated that il 2 TNFα/B7 1 co modified tumor cells possessed a lower tumorigenicity in vivo and an improved tumor specific vaccine potency compared with single gene transfectant ( P il 2 TNFα and B7 1 together induced a more potent antitumor immune response than either molecule alone, 25% higher than il 2 TNFα and 20% higher than B7 1, respectively Conclusion The il 2 TNFα fusion gene and B7 1 gene act in concert to improve their antitumor effectiveness

关键词： tumor · active immune · il 2 TNFα/B7 1