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Alzheimer’s in a dish-induced pluripotent stem cell-based disease modeling

Translational Neurodegeneration 2019年第1期8卷 257-269页

作者： Sherida de Leeuw Christian Tackenberg Institute for Regenerative Medicine University of ZurichSchlierenSwitzerland Neuroscience Center Zurich University of Zurich and ETH ZurichZurichSwitzerland

Background:Since the discovery of the induced pluripotent stem cell(ipsc)technique more than a decade ago,extensive progress has been made to develop clinically relevant cell culture ***’s disease(AD)is the most common neurodegenerative disease,accounting for approximately two thirds of all cases of *** massively increasing number of affected individuals explains the major interest of research in this disease as well as the strong need for better understanding of disease *** body:ipsc-derived neural cells have been widely used to recapitulating key aspects of *** this Review we highlight the progress made in studying AD pathophysiology and address the currently available techniques,such as specific differentiation techniques for AD-relevant cell types as well as 2D and 3D ***,we critically discuss the key challenges and future directions of this field and how some of the major limitations of the ipsc technique may be ***:Stem cell-based disease models have the potential to induce a paradigm shift in biomedical *** particular,the combination of the ipsc technology with recent advances in gene editing or 3D cell cultures represents a breakthrough for in vitro disease modeling and provides a platform for a better understanding of disease mechanisms in human cells and the discovery of novel therapeutics.

关键词： Alzheimer’s disease Induced pluripotent stem cells ipsc-derived neurons ipsc-derived astrocytes ipscderived microglia Disease modeling

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