检索结果-南通市图书馆

Advances in nanomaterials for treatment of hypoxic tumor

National Science Review 2021年第2期8卷 134-150页

作者： Mei-Zhen Zou Wen-Long Liu Han-Shi Chen Xue-Feng Bai Fan Gao Jing-Jie Ye Han Cheng Xian-Zheng Zhang The Institute for Advanced Studies Key Laboratory of Biomedical Polymers of Ministry of Education & Department of ChemistryWuhan University School of Chemistry and Materials Science South-Central University for Nationalities

The hypoxic tumor microenvironment is characterized by disordered vasculature and rapid proliferation of tumors, resulting from tumor invasion, progression and metastasis. The hypoxic conditions restrict efficiency of tumor therapies, such as chemotherapy, radiotherapy, phototherapy and immunotherapy,leading to serious results of tumor recurrence and high mortality. Recently, research has concentrated on developing functional nanomaterials to treat hypoxic tumors. In this review, we categorize such nanomaterials into(i) nanomaterials that elevate oxygen levels in tumors for enhanced oxygen-dependent tumor therapy and(ii) nanomaterials with diminished oxygen dependence for hypoxic tumor *** elevate oxygen levels in tumors, oxygen-carrying nanomaterials, oxygen-generating nanomaterials and oxygen-economizing nanomaterials can be used. To diminish oxygen dependence of nanomaterials for hypoxic tumor therapy, therapeutic gas-generating nanomaterials and radical-generating nanomaterials can be used. The biocompatibility and therapeutic efficacy of these nanomaterials are discussed.

关键词： nanomaterials hypoxic tumor tumor therapy oxygen

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Sono-ReCORMs for synergetic sonodynamic-gas therapy of hypoxic tumor

引用

Chinese Chemical Letters 2023年第1期34卷 295-299页

作者： Yue Li Nong Lu Qitian Lin Haobing Wang Zhuoming Liang Yujuan Lu Pingyu Zhang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China Whittle School and Studios Shenzhen Campus Shenzhen 518066China

Carbon monoxide(CO)gas therapy,a novel anti-tumor technique based on the cytotoxicity from the CO released in situ,has become one of the hot topics in cancer *** the technique is oxygenindependent,it displays promising therapeutic effect for hypoxic tumor where traditional photodynamic therapy shows limited efficacy and insufficient penetration *** fully address these limitations of PDT,we propose a synergetic sonodynamic-CO gas releasing strategy for the therapy of hypoxic *** this work,two rhenium(Ⅰ)tricarbonyl complexes with different substituted ligands are investigated for US-triggered ROS generation and CO *** results indicated that the electron-donating NMe2-substituted complex(Re-NMe2)exhibits stronger luminescence intensity and generates more singlet oxygen(1O2)than the electron-withdrawing NO2-substituted complex(Re-NO2).In addition,Re-NMe2displays release of CO triggered by US,thus showing high sono-cytotoxicity to tumor cells in-vitro and *** strong ROS-generating capability combined with rapid CO-releasing feature from Re-NMe2has made it a powerful tool for the efficient treatment of hypoxic tumor.

关键词： Synergetic sonodynamic-gas therapy Carbon monoxide(CO) Rhenium(Ⅰ)tricarbonyl complex hypoxic tumor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors

引用

Nano Research 2021年第3期14卷 667-673页

作者： Yinghua Zhang Huifang Liu Xinyue Dai Hang Li Xiaohan Zhou Shizhu Chen Jinchao Zhang Xing-Jie Liang Zhenhua Li College of Chemistry&Environmental Science Analytical Chemistry Key Laboratory of Hebei ProvinceChemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding071002China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Institute of Life Science and Green DevelopmentHebei UniversityBaoding071002China College of Pharmaceutical Science Key Laboratory of Pharmaceutical Quality Control of Hebei ProvinceHebei UniversityBaoding071002China Beijing Pharmaceutical Group Company Limited Beijing100101China The National Institutes of Pharmaceutical R&D Co. Ltd.China Resources Pharmaceutical Group LimitedBeijing102206China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing100190China

tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy,as well as predisposing for increased tumor ***,strategies for the eradication of the hypoxic tumor are highly *** therapy(PDT)is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a *** to traditional radiotherapy and chemotherapy,photodynamic therapy has many advantages,such as good selectivity,low toxicity,and less trauma and ***,PDT is oxygen-dependent,and the lack of oxygen in hypoxic tumors renders photodynamic therapy ***,the earliest photosynthetic oxygen-generating organisms,can utilize water as an electron donor to reduce CO_(2) into organic carbon compounds along with continuously releasing oxygen under *** by this,herein,cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles(UCNP)to construct a self-supplying oxygen PDT *** in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared(NIR)light using UCNP as a light harvesting antenna.A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms.

关键词： self-supplying oxygen cyanobacteria hypoxic tumor photodynamic therapy upconversion nanoparticles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：