检索结果-南通市图书馆

Moderate hypothermia.prevents neural cell apoptosis following spinal cord ischemia in rabbits

Cell Research 2005年第5期15卷 387-393页

作者： Lei Ming WANG1,3,*, Ye YAN2,*, Liang Jian ZOU1, Nai He JING2, **, Zhi Yun XU1, ** 1Department of Cardiovascular Surgery, Changhai Hospital, Shanghai 200433, China 2Laboratory of Molecular Cell Biology, Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shang- hai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 3Department of Cardiovascular Surgery, The 85th Hospital, Shanghai 200052, China Department of Cardiovascular Surgery Changhai Hospital Shanghai China Department of Cardiovascular Surgery The 85th Hospital Shanghai China Laboratory of Molecular Cell Biology Laboratory of Stem Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

Paraplegia is a disastrous complication after operations of descending and thoracoabdominal aortic aneurysm. Re- gional hypothermia.protects against spinal cord ischemia although the protective mechanism is not well know. The objective of this study is to examine whether hypothermia.protects the spinal cord by preventing apoptosis of nerve cell and also investigate a possible mechanism involved in hypothermia.neuroprotection. Cell apoptosis with necrosis was evident in the spinal cord 24 h after 30 min of ischemia. Moderate hypothermia.decreased the incidence of apoptotic nerve cells. Both cell apoptosis and necrosis were attenuated by hypothermia. p53 expression increased and bcl-2 expression declined after ischemia, while hypothermia.mitigated these changes. This study suggests that apoptosis contributes to cell death after spinal cord ischemia, and that moderate hypothermia.can prevent nerve cell apoptosis by a mechanism associated with bcl-2 and p53 genes.

关键词： spinal cord ischemia apoptosis hypothermia.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

K+-FREE INDUCED EARLY AFTERDEPOL-ARIZATION IN CARDIAC VENTRICULAR FIBERS OF GUINEA PIG AFTER COLD TREATMENT

引用

Science in China,Ser.B 1988年第12期31卷 1439-1446页

作者：王忠民刘泰槰刘克球 Department of Biology Peking University

The genesis and elimination of early afterdepolarizations （EADs） have been investigated in guinea pig cardiac ventricular fibers after a short period of cooling （5h, 2—4℃）. After rewarming them to 37℃, EADs could be induced by K+-free superfusion at an appropriate driving stimulation （0.2 Hz） in all preparations. A high level plateau, which linearly increases its duration with time, appears ahead of EADs. The critical point of the plateau occurred steadily at the level of -47±4 mV. Two types of triggered activity, all of which are the rhythmic activities in low level of membrane potential （-50 to -60 mV）, appear on the platcau. There is no significant change after overdriving. Agonists of the Na-K pump （K+ and Tl+） could stop the rhythmic activity immediately and turn the low level of membrane potential to high one. The results showed that high level plateau is the basis of genesis of EADs, and the activation of Na-K pump plays an important part in stopping triggered rhythms arising from EADs.

关键词： early afterdepolarization triggered aetivity ventrieular fibers low potassium hypothermia.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：