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hyperbolic positive mass theorem under modified energy condition

Science China Mathematics 2008年第12期51卷 2189-2197页

作者： XIE NaQing Institute of Mathematics, School of Mathematical Sciences, Fudan University, Shanghai 200433, China Institute of Mathematics School of Mathematical Sciences Fudan University Shanghai China

We provide two new positive mass theorems under respective modified energy conditions allowing T00 negative on some compact set for certain modified asymptotically hyperbolic manifolds. This work is analogous to Zhang... 详细信息

关键词： positive mass theorem modified energy condition modified asymptotically hyper- bolic

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Effect of LDL-apheresis on plasma lipids, chitotriosidase and anti-oxLDL antibodies in heterozygous familial hypercholes-terolemia

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Journal of Biomedical Science and Engineering 2009年第7期2卷 499-505页

作者： Maria Musumeci Francesco Pappalardo GianCarlo Tonolo Fernando Torrisi Francesca Gullo Salvatore Musumeci 不详

Forty four consecutive subjects aged 29-58 years (21 males and 23 females) with a clinical diagnosis of heterozygous familial hypercholesterolemia periodically treated every 30 days with LDL-apheresis for statin resistance, were enrolled in this study. A lipid profile was obtained immediately before starting LDL-apheresis, a second profile was obtained within four hours after LDL-apheresis. Chit activity and anti-oxLDL levels were determined with appropriate methods in all patients before and after LDL- apheresis. Total cholesterol, LDL-cholesterol, HDL- cholesterol and triglycerides decreased significantly after LDL-apheresis, while the variations of Chit activity and anti-oxLDL were not significant after LDL-apheresis. The correlation between Chit and total cholesterol was negative (r= –0.44 and –0.50 res- pectively) before and after LDL-apheresis as between Chit and LDL-cholesterol (r= –0.45 and –0.55 respectively). Anti-oxLDL concentration before and after LDL-apheresis positively correlated with Chit activity (r= 0.52 and r = 0.63 respectively), negatively with total cholesterol (r= –0.33 and r = –0.35 res- pectively) and with LDL (r = –0.32 and r = –0.21 respectively). We think that removing LDL with LDL-apheresis the anti-oxLDL/oxLDL ratio could increase and the excess of anti-oxLDL could induce macrophage activation through the surface Fc receptors. Alternatively with high levels of LDL- cholesterol, the deposition of foam cells represent the characteristic evolution of atherosclerosis process. Macrophage activation in the heterozygous familial hypercholesterolemia could represent an attempt for re-modeling the vessel wall, reducing the growth of lipid plaques.

关键词： LDL-Apheresis Heterozygous Familial hyper- Cholesterolemia Lipids Chitotriosidase Anti-oxLDL Anti- bodies Sardinia

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