检索结果-南通市图书馆

A contribution to the study of the modified Marschalk reaction:hydroxymethylation of 6,8-O-dimethyl emodin

Chinese Chemical Letters 2010年第5期21卷 568-571页

作者： Hai Shan Jin,Li Ming Zhao School of Chemistry and Chemical Engineering,Xuzhou Normal University,Xuzhou 221116,China School of Chemistry and Chemical Engineering Xuzhou Normal University Xuzhou 221116 China

hydroxymethylation of 6,8-O-dimethyl emodin was easily achieved in good yields by the modified Marschalk reaction.The influence of the amount of solvent,base and formaldehyde toward the hydroxymethylation was discussed.The results showed that a relatively dilute reaction solution facilitated the generation of the desired 2-hydromethyl product,while the thick reaction solution benefited the generation of the methylated quinizarins.

关键词： Marschalk reaction hydroxymethylation Emodin Antitumor activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epigenetics in psychiatry:Beyond DNA methylation

引用

World Journal of Psychiatry 2023年第6期13卷 319-330页

作者： Katarina Kouter IrisŠalamon Arčan Alja VidetičPaska Faculty of Medicine Institute of Microbiology and ImmunologyUniversity of LjubljanaLjubljana 1000Slovenia Faculty of Medicine Institute of Biochemistry and Molecular GeneticsUniversity of LjubljanaLjubljana 1000Slovenia

The global burden of psychopathologies appears to be underestimated,since the global psychiatric disorder burden is exceeding other medical burdens.To be able to address this problem more effectively,we need to better understand the etiology of psychiatric disorders.One of the hallmarks of psychiatric disorders appears to be epigenetic dysregulation.While some epigenetic modifications(such as DNA methylation)are well known and studied,the roles of others have been investigated much less.DNA hydroxymethylation is a rarely studied epigenetic modification,which as well as being an intermediate stage in the DNA demethylation cycle is also an independent steady cell state involved in neurodevelopment and plasticity.In contrast to DNA methylation,DNA hydroxymethylation appears to be related to an increase in gene expression and subsequent protein expression.Although no particular gene or genetic locus can be at this point linked to changes in DNA hydroxymethylation in psychiatric disorders,the epigenetic marks present good potential for biomarker identification because the epigenetic landscape is a result of the interplay between genes and environment,which both influence the development of psychiatric disorders,and because hydoxymethylation changes are particularly enriched in the brain and in synapse-related genes.

关键词： Mood disorders Suicide Schizophrenia Bipolar disorder hydroxymethylation 5-hydroxymethycytosine Gene expression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Kaiso mainly locates in the nucleus in vivo and binds to methylated,but not hydroxymethylated DNA

引用

Chinese Journal of Cancer Research 2015年第2期27卷 148-155页

作者： Sisi Qin Baozhen Zhang Wei Tian Liankun Gu Zheming Lu Dajun Deng Beijing Key Laboratory of Carcinogenesis and Translational Research Division of Cancer EtiologyPeking University Cancer Hospital & Institute

Objective： Kaiso is upregulated in many cancers and proposed to bind with both methylated- and unmethylated-DNA in the nucleus as a transcriptional repressor. The objective is to define its subcellnlar localization in vivo and exact binding DNA sequences in cells. Methods： Compartmentalization of exogenous Kaiso in cells was tracked with enhanced green fluorescence protein （EGFP） tag. The endogenous Kaiso expression in gastric carcinoma tissue was examined with immunohistochemical staining. Kaiso-DNA binding was tested using electrophoretic mobility shift assay （EMSA） and chromatin immunoprecipitation assay （CHIP）. Results： Kaiso mainly localized in the nucleus of cancer and stromal cells in vivo, but remained in the cytoplasm of cultured cells. Most importantly, nuclear Kaiso can bind with the methylated-CGCG- containing sequence in the CDKN2A promoter, but not with the hydroxymethylated-CGCG sequence in HCT116 cells. Conclusions： Kaiso locates mainly in the nucleus in vivo where it binds with the methylated-CGCG sequences, but does not bind with the hydroxymethylated-CGCG sequences.

关键词： Kaiso compartmentalization DNA binding methylation hydroxymethylation CDKN2A

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sulfonation of Hydroxymethylated Lignin and Its Application

引用

Journal of Bioresources and Bioproducts 2019年第2期4卷 80-88页

作者： Weijue GAOD John P.W.INWOODD Pedram FATEHI Department of Chemical Engineering and Green Processes Research Centre Lakehead University955 Oliver RoadThunder Bay P7B5E1Canada

To valorize kraft lignin,hydroxymethylation and sulfonation were applied on this under-utilized,but vastly available,material.The hydroxymethylation pretreatment was conducted as means to improve the reactivity of lignin.The sulfonation of hydroxymethylated kraft lignin was investigated by sulfuric acid and sodium sulfite treatments under various conditions.The modified lignin samples were characterized for their charge density,solubility,elemental components,and molecular weights.The results showed that the hydroxymethylation facilitated the sulfonation by sodium sulfite,yielding a product(SSH-lignin)with the charge density of-1.2 meq/g and water solubility of 10 g/L under the conditions of Ns_(2)SO_(3)/lignin molar ratio of 0.49 mol/mol,95℃and 3 h.On the other hand,hydroxymethylation hindered the sulfonation of lignin by sulfuric acid,yielding a product(SAH-lignin)with the charge density of–0.46 meq/g and solubility of 0.9 g/L under the conditions of H_(2)SO_(4)/lignin molar ratio of 14.8 mol/mol,80℃and 1 h.The SSH-lignin had a high adsorption on kaolinite(17 mg/g)at a lignin concentration of 40 g/L.The sulfonated lignins were also found to be effective coagulant for the cationic dye ethyl violet.

关键词： kraft lignin hydroxymethylation sulfonation adsorption dye removal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liguzinediol的合成

引用

中国医药工业杂志 2014年第3期45卷 210-211页

作者：周莹李伟陈磊陈施伟王天麟南京中医药大学药学院江苏南京210023

Liguzinediol(1),化学名为2,5-二羟甲基-3,6-二甲基吡嗪,对正常以及急、慢性心力衰竭模型大鼠心脏具有较强的正性肌力作用,且无心律失常等不良反应[1-4]。1可通过作用于心肌细胞内的SERCA2a靶点发挥正性肌力作用[5]。研究表明[6-8],

关键词： liguzinediol radical reaction hydroxymethylation synthesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：