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Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress

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Chinese Medical Journal 2012年第9期125卷 1633-1637页

作者： WANG Qi-jin ZHA Xiao-juan KANG Zhi-min XU Mao-jin HUANG Qin ZOU Da-jin Department of Endocrinology Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Diving Medicine Faculty of Naval Medicine Second Military Medical University Shanghai 200433 China

Background Molecular hydrogen, as a novel antioxidant, has been proven effective in treating many diseases. This study aimed to evaluate the therapeutic effects of hydrogen saturated saline in treatment of a rat model of diabetes mellitus and a rat model of insulin resistant. Methods A rat diabetes mellitus model was established by feeding a high fat/high carbohydrate diet followed by injection of a small dose of streptozotocin, and an insulin resistant model was induced with a high glucose and high fat diet. hydrogen saturated saline was administered to rats with both models conditions on a daily basis for eight weeks. A pioglitazone-treated group and normal saline-treated group served as positive and negative controls. The general condition, body weight, blood glucose, blood lipids, and serum insulin levels of rats were examined at the 8th week after treatment. The oxidative stress indices, including serum superoxide dismutase （SOD）, glutathione （GSH） and malondialdehyde （MDA） were also evaluated after eight weeks of treatment using the commercial kits.Results hydrogen saturated saline showed great efficiency in improving the insulin sensitivity and lowering blood glucose and lipids. Meanwhile, the therapeutic effects of hydrogen saturated saline were superior to those of pioglitazone. hydrogen saturated saline markedly attenuated the MDA level and elevated the levels of antioxidants SOD and GSH. Conclusion hydrogen saturated saline may improve the insulin resistance and alleviate the symptoms of diabetes mellitus by reducing the oxidative stress and enhancing the anti-oxidant system.

关键词： diabetes mellitus hydrogen saturated saline oxidative stress insulin resistance

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saturated hydrogen saline protects rats from acute lung injury induced by paraquat

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World Journal of Emergency Medicine 2011年第2期2卷 149-153页

作者： BACKGROUND: Hui-li Zhang Yuan-fci Liu Xu-rui Luo Wei-hua Tan Liang Huang Department of Emergency Medicine First Affiliated Hospital ofNanchang University Nanchang 330006 China

BACKGROUND： Paraquat （PQ） intoxication causes lung oxidative stress damage. saturated hydrogen saline, a newly explored antioxidant, has been documented to play a powerful antioxidant role in preventing oxidative stress damage. This study aimed to investigate the protective effects and the possible mechanisms of intoxication on rats with acute lung injury （ALl） caused by paraquat poisoning. METHODS： Thirty PQ poisoned rats were randomly divided into a PQ intoxication group （intoxication group）, a saturated hydrogen saline intervention group （intervention group）, and a control group, with 10 rats in each group. The first two groups accepted an intragastric administration of PQ at a dose of 50 mg/kg for every single rat, and the control group was fed with a same volume of normal saline. Five mL/kg of saturated hydrogen saline was given to the intervention group three times a day by peritoneal injection for three days after intoxication. Arterial blood gas was detected on the third day. The rats were executed and their lungs were taken for measurement of wet dry weight ratio, homogenate malondialdehyde （MDA）, and 8-hydroxy-2＇-deoxyguanosine （8-OhdG）. Histological changes of the lungs were also observed. RESULTS： Compared with the control group, the intoxication group had more serious hypoxemia, greater wet/dry weight ratio, higher MDA level, higher expression of 8-OhdG and more severe lung damage （P〈0.01 or P〈0.05）. However, after intervention with saturated hydrogen saline, poisoned animals turned to have lighter hypoxemia, smaller wet/dry weight ratio, lower MDA level, lower expression of 8-OhdG, and milder lung damage （P〈0.01 or P〈0.05）. CONCLUSIONS： saturated hydrogen sal by PQ. Possibly, it can neutralize toxic oxygen injury induced by PQ. ne is effective in preventing acute lung injury caused radicals selectively and alleviate the oxidative stress

关键词： Paraquat Oxidative stress Lung hydrogen saturated saline 8-OHdG Malondialdehyde Sprague-Dawley rat

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