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Environment adaptive hydrogels for extreme conditions:a review

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Biosurface and Biotribology 2019年第4期5卷 104-109页

作者： Yanan Jiang Xiong Lu Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong University610031 ChengduSichuanPeople’s Republic of China

hydrogels have attracted extensive attention due to their excellent swellability,permeability,and biocompatibility.In recent years,the demand for multifunctional hydrogels has been on the increase;there is also an increased need to utilise hydrogels in more varied and extreme applications,such as low temperature,anoxic environment,ultraviolet damage,burns,and the marine environment.Furthermore,traditional hydrogel materials cannot meet the requirements of the application in extreme environments.Therefore,it is necessary to design and develop hydrogels that are adaptable to certain extreme conditions.This review summarises recent advances in hydrogels that meet application requirements under extreme conditions,particularly in the biomedical field and prospects for their future development.

关键词： conditions extreme hydrogel

Hyaluronic acid-based hydrogels with tobacco mosaic virus containing cell adhesive peptide induce bone repair in normal and osteoporotic rats

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Biomaterials Translational 2020年第1期1卷 89-98页

作者： Jishan Yuan Panita Maturavongsadit Zhihui Zhou Bin Lv Yuan Lin Jia Yang Jittima Amie Luckanagul Department of Orthopaedic Surgery the Affiliated First People’s Hospital to Jiangsu UniversityZhenjiangJiangsu ProvinceChina Department of Chemistry and Biochemistry University of South CarolinaColumbiaSCUSA Joint Department of Biomedical Engineering North Carolina State University and The University of North Carolina at Chapel HillChapel HillNCUSA The State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin ProvinceChina Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkokThailand Research Unit for Plant-produced Pharmaceuticals Chulalongkorn UniversityBangkokThailand.

Tobacco mosaic virus(TMV)has been studied as a multi-functional agent for bone tissue engineering.An osteo-inductive effect of wild-type TMV has been reported,as it can significantly enhance the bone differentiation potential of bone marrow stromal cells both on a two-dimensional substrate and in a three-dimensional(3D)hydrogel system.A TMV mutant(TMV-RGD1)was created which featured the adhesion peptide arginyl-glycyl-aspartic acid(RGD),the most common peptide motif responsible for cell adhesion to the extracellular matrix,on the surface of the virus particle to enhance the bio-functionality of the scaffold material.We hypothesised that the incorporation of either wild-type TMV or TMV-RGD1 in the 3D hydrogel scaffold would induce bone healing in critical size defects of the cranial segmental bone.We have previously tested the virus-functionalised scaffolds,in vitro,with a hyaluronic acid-based system as an in-situ hydrogel platform for 3D cell encapsulation,culture,and differentiation.The results of these experiments suggested the potential of the virus-functionalised hydrogel to promote in vitro stem cell differentiation.The hydrogel-forming system we employed was shown to be safe and biocompatible in vivo.Here,we further explored the physiological responses regarding bone regeneration of a calvarial defect in both normal and osteoporotic ovariectomized rat models.Our results,based on histological analysis in both animal models,suggested that both wild-type TMV and TMV-RGD1 functionalised hydrogels could accelerate bone regeneration,without systemic toxicity,evaluated by blood counts.New bone formation was intensified by the incorporation of the RGD-mutant viral particles.This finding increased the potential for use of the rodshaped plant virus as a platform for the addition of powerful biofunctionality for tissue engineering applications.This study was approved by the Ethics Committee on Animal Use of the Zhenjiang Affiliated First People’s Hospital affiliated to Jiangsu University.

关键词： bone regeneration calvarial defect hydrogel osteoporosis tobacco mosaic virus

3D bioprinting of cell-laden constructs for regenerative medicine

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Engineered Regeneration

Engineered Regeneration 2021年第1期2卷 195-205页

作者： Cuidi Li Wenguo Cui Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Human tissue consists of various tissue-specific cells,extracellular matrix components and microstructures,and growth factors.With promising multi-cell and multi-material integration manufacturing feature,3D extrusion bioprinting has shown outstanding application potential in the field of regenerative medicine.For functional tissue regeneration,bioprinted constructs not only play the role of a cell-delivery system,but also serve as an important host niche for cell proliferation and work.In order to meet the specific requirements of different tissue regeneration,development of bio-inks that provide tissue-specific biophysical cues and biochemical microenvironments is an important research topic.Furthermore,reconstruction of tissues with anisotropic structure,such as articular cartilage and meniscus,largely depend on the design of 3D bioprinting path for accurate arrangement of specific bio-inks.This review summarizes the advanced designs of tissue-specific 3D bioprinting of cell-laden constructs for functional regeneration of skeletal and locomotor systems such as bone,cartilage,skeletal muscle,and blood vessels via the collaboration of bio-ink and printing processes.It may provide a basis for synergistic design for functional regenerative constructs bioprinting in the future.

关键词： 3D bioprinting Tissue regeneration hydrogel Microenvironment

Mechanical and antibacterial properties of tannic acid-encapsulated carboxymethyl chitosan/polyvinyl alcohol hydrogels

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Engineered Regeneration

Engineered Regeneration 2021年第1期2卷 57-62页

作者： Xiaofan Feng Xiuling Hou Congjing Cui Shibin Sun Sahiya Sadik Shaohua Wu Fang Zhou College of Textiles and Clothing Qingdao UniversityShandong 266061China

The objective of this study was to develop an effective,potential wound dressing,which was constructed with a composite hydrogel of poly(vinyl alcohol)(PVA),carboxymethyl chitosan(CMC)and tannic acid(TA)by cryogenic treatment and freeze-drying method.The as-prepared TA-crosslinked PVA/CMC hydrogels exhibited interconnected pore structure with the mean pore size of roughly 3.7𝜇m.We found that the compressive strength and stiffness of composite hydrogel increased when the TA component was introduced.However,the PVA/CMC-TA hydrogel possessed obviously lower swell property than that of the TA-free PVA/CMC hydrogel.We also found that the TA addition significantly improved the antibacterial capacity of the as-prepared hydrogel.Moreover,the inhibition zone test showed that the antibacterial activity of PVA/CMC-TA against S.aureus bacteria was greater than that against E.coli.The biological results indicated that the PVA/CMC-TA hydrogel exhibited good cytocompatibility to natural human dermal fibroblasts.In summary,our PVA/CMC-TA composite hydrogel exhibited promising mechanical and antibacterial properties,which showed great potential application as wound healing materials.

关键词： hydrogel Carboxymethyl chitosan Tannic acid PVA Antibacterial property

Synthesis and Swelling Properties of Thermosensitive hydrogels based on Terpolymerization

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Chinese Chemical Letters 2005年第5期16卷 675-676页

作者： CaiHuaNI XianYuZENG HeHUANG SchoolofChemicalandMaterialEngineering SouthernYangtzeUniversiyWuxi214001 CollegeofMaterialsScienceandEngineering BeijingUniversityofChemicalTechnologyBeijing100029 SchoolofChemistryandMaterialsScience HubeiUniversityWuhan43006

Novel thermosensitive hydrogels based on polymerization of N-isopropyl acrylamide, Sodium acrylate, and diacetone acrylamide were synthesized. The swelling ratio and dynamic swelling were investigated. The results indicated that the hydrogels exhibited high water uptake and themosensitivity. The swelling properties and volume phase transition temperature could be adjusted by contents of the comonomers in the gels.

关键词： hydrogel thermosensitivity swelling property.

Bioinspired hydrogels with Muscle-Like Structure for AIEgen-Guided Selective Self-Healing

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CCS Chemistry 2021年第4期3卷 1146-1156页

作者： Xiaofan Ji Zhao Li Yubing Hu Huilin Xie Wenjie Wu Fengyan Song Haixiang Liu Jianguo Wang Meijuan Jiang Jacky WYLam Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Studyand Department of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyHong Kong Institute of Engineering Medicine Beijing Institute of TechnologyBeijing 100081 School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074 HKUST Shenzhen Research Institute Shenzhen 518057 Center for Aggregation-Induced Emission SCUT-HKUST Joint Research InstitutesState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640

Living systems,including human beings,animals,and plants,display the power to self-heal spontaneously after being damaged.The self-healing is usually selective,which means that the healing efficiency is related to the spatial distribution of dynamic interfacial interactions of the two rupturing surfaces.Current artificial systems use noncovalent interactions or dynamic covalent bonds to prepare self-healing materials.However,they can only show nonselective self-healing due to their homogeneous internal structures.Herein,we report the construction of a composite hydrogel Gel-C consisting of three different self-healing hydrogels(Gel-Y,Gel-G,and Gel-O)through the use of classic bilayer hydrogel technology.When the composite hydrogel was cut into two pieces,the relative orientation of the parts was rotated through different angles to study the differences in self-healing.Owing to the heterogeneous internal structure of the composite hydrogel and the recognition specificity of each included hydrogel,the interfacial dynamic interactions distribution of the two rupturing surfaces is diverse.The results of tensile tests demonstrated that these rotated samples exhibited different self-healing efficiencies.This system realized the transformation of artificial materials from nonselective self-healing to selective selfhealing,providing inspiration for the development of novel biological materials and engineering materials.

关键词： aggregation-induced emission fluorescence hydrogel noncovalent interactions dynamic covalent interactions self-healing

Three-dimensional hydrogel culture conditions promote human induced pluripotent stem cells differentiated hepatocytes

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Three-dimensional hydrogel culture conditions promote human ...

Friction reduction of glycocalyx of human endothelial cells cultured on anionic hydrogel scaffolds

第二十四次全国中西医结合肝病学术会议

作者： Ying Luo Yingtang Gao Cheng Lou Sui Zhang Zhengyan Zhu Qianzhe Xing Peng Wang Tong Liu Chenglong Li Li Jing Hui Liu Wenxia Shi Zhi Du Key Laboratory of Artificial Cell Institute of Hepatobiliary DiseaseThe Third Central Hospital of Tianjin China Department of Hepatobiliary Surgery The Third Central Hospital of Tianjin Department of Cardiology The University of Texas MD Anderson Cancer Center

Background & Aims:The use of differentiated hepatocytes from hiPSCs is increasingly favored for BAL,but,inferior function limited it application.In this study,we aimed to establish a 3D condition to mimic the environment that of hepatogenesis in vivoforlarge-scale culture and higher throughput BAL.Methods:We utilize a synthetic hydrogel to create the HLCs-based spheroids in the 3D condition and evaluate the maturity of spheroids function.Results:We differentiated hiPSCs to DE cells with EB formation in monolayer condition in the first stage,and then dissociatedhiPSCs-DE into single cells to implante into hydrogel via self-aggregatingto form spheroid.The HLCs-based spheroids showed expression of hepatocyte markers.The ALB secretion,Urea production and glycogen synthesis by HLCs in 3D conditions are significantly higher than the cells in 2D conditions,or HepG2.In addition,metabolic activities of the CYP450 enzymes were also improved while cells differented in 3D condition.Conclusions:This 3Dhydrogel conditions can promote human induced pluripotent stem cellsdifferentiated hepatocytes,and it may be have the potential application of fordifferentiated hepatocytes from hiPSCs as a source for BAL.

关键词： human induced pluripotent stem cells differentiation 3D condition hydrogel

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Friction reduction of glycocalyx of human endothelial cells ...

Self-healable, recyclable, ultrastretchable, and high-performanceNO_(2) sensors based on an organohydrogel for room and sub-zero temperature and wireless operation

2007年全国高分子学术论文报告会

作者：陈咏梅龚建萍 Takayuki Kurokawa Masaru Tanaka Yasuda Kazunori Sadaaki Yamamoto Masatsugu Shimomura Yoshihito Osada Graduate School of Science Hokkaido University Sapporo 060-0810Japan Creative Research Initiative’SOUSEI’Hokkaido UniversitySapporo 001-0021 Graduate School of Science Hokkaido University Sapporo 060-0810Japan Graduate School of Science Hokkaido University Sapporo 060-0810Japan Nanotechnology Research Center Research Institute for Electronic Science Hokkaido UniversitySapporo001-0021Japan Creative Research Initiative’SOUSEI’ Hokkaido University Sapporo 001-0021 School of MedicineHokkaido UniversitySapporo 060-0810Japan Creative Research Initiative’SOUSEI’ Hokkaido University Sapporo 001-0021 Nanotechnology Research Center Research Institute for Electronic Science Hokkaido UniversitySapporo001-0021Japan Graduate School of Science Hokkaido University Sapporo 060-0810Japan

＜正＞In the in vivo vascular system,the inner surface of blood vessel is covered by a monolayer of endothelial cell（EC）that exposes to the blood flow.With great interesting, the red blood cells can deform and smoothly squeeze though the capillary of a diameter much smaller.In this process,the friction should occur between soft ECs and deformable blood red cells.Apparently,only when the surface friction between the inner surface wall of

关键词： hydrogel cell culture glycocalyx friction platelet adhesion

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SmartMat 2023年第1期4卷 168-184页

作者： Qiongling Ding Zijing Zhou Hao Wang Zixuan Wu Kai Tao Bo-Ru Yang Xi Xie Jun Fu Jin Wu State Key Laboratory of Optoelectronic Materials and Technologies and the Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhouChina Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace Northwestern Polytechnical UniversityXi'anChina School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhouChina

To date,development of high-performance,stretchable gas sensors operating at and below room temperature(RT)remains a challenge in terms of traditional sensing materials.Herein,we report on a high-performance NO_(2) gas sensor based on a self-healable,recyclable,ultrastretchable,and stable polyvinyl alcohol–cellulose nanofibril double-network organohydrogel,which features ultrahigh sensitivity(372%/ppm),low limit of detection(2.23 ppb),relatively fast response and recovery time(41/144 s for 250 ppb NO_(2)),good selectivity against interfering gases(NH3,CO_(2),ethanol,and acetone),excellent reversibility,repeatability,and long-term stability at RT or even at−20°C.In particular,this sensor shows outstanding stability against large deformations and mechanical damages so that it works normally after rapid self-healing or remolding after undergoing mechanical damage without significant performance degradation,which has major advantages compared to state-of-the-art gas sensors.The high NO_(2) sensitivity and selectivity are attributed to the selective redox reactions at the threephase interface of gas,gel,and electrode,which is even boosted by applying tensile strain.With a specific electrical circuit design,a wireless NO_(2) alarm system based on this sensor is created to enable continuous,real-time,and wireless NO_(2) detection to avoid the risk of exposure to NO_(2) higher than threshold concentrations.

关键词： hydrogel NO_(2)gas sensor self-healing and recyclable organohydrogel stretchable and wearable electronics wireless gas sensor