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Fabrication and Manipulation of Magnetic Composite Particles with Specific Shape and Size

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Chemical Research in Chinese Universities 2016年第6期32卷 1052-1056页

作者： SHI Qing WANG Gong LU Chao XIA Hong State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering JiIin University Changchun 130012 R R. China

The fabrication of microscale polyethylene glycol diacrylate（PEGDA） hydrogel particles was demon-strated via magnetic property ultraviolet（UV） lithography techniques, polydimethylsiloxane（PDMS） soft stamp pre-paration techniques and micro-nano imprint technology in this paper. The results of compositional and morphologicalcharacterizations of magnetic microparticles show that the Fe304 nanoparticles with an average diameter of 100 nmare uniformly dispersed in hydrogel. Owing to the excellent magnetism of Fe304 nanoparticles, the fabricated hydro-gel microparticles with different sizes and shapes were manipulated in water via applying an external magnetic fields.Three types of motions, translation, rotation and flip, were demonstrated with the manipulator. These microscalemagnetic PEGDA hydrogel particles have a great application potential in manufacturing process, micro/nanomotors,and machines.

关键词： Magnetic nanoparticle hydrogel particle Micro-nano imprint Magnetic motor

Synthesis and Characterization of Poly (hydroxylethyl, octanediamine)-DL-aspartamide: a New Tissue Engineering Scaffolds

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Chinese Chemical Letters 2006年第2期17卷 191-194页

作者： Gu Ping TANG Xiao Xiao SONG Da LI Department of Chemistry Zhejiang University Hangzhou 310028 Department of Medical Zhejiang University Hangzhou 310006

Poly （hydroxyethyl, octanediamine）-DL-aspartamide （PHOA） hydrogels were prepared by adding mixture of 1,8-octanediamine and ethanolamine to PA in DMF at room temperature. The properties of the hydrogels were inves... 详细信息

关键词： Octanediamine aspartamide hydrogel cell adhesion.

Imitation of drug metabolism in cell co-culture microcapsule model using a microfluidic chip platform coupled to mass spectrometry

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Chinese Chemical Letters 2020年第2期31卷 451-454页

作者： Yajing Zheng Zengnan Wu Jin-Ming Lin Ling Lin Beijing Key Laboratory of Microanalytical Methods and Instrumentation Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

In this work,a multi-functional analysis platform by coupling a microfluidic chip to a mass spectrometry(MS) detector was described.We constructed a three-dimensional tumor-endothelial co-culture model for simulating drug resistance during tumor treatment.On this specially designed integrated platform,the first step was to prepare heterogeneous cell-encapsulated alginate microcapsules for threedimensional co-culture,and the second step was to achieve on-line perfusion culture and continuous drug stimulation on chip.It facilitates cell proliferation analysis and the collection of metabolism medium.After micro solid phase extraction column(SPE) pretreatment,subsequent mass spectrometry could detect drug metabolism.The high activity of two kinds of cells(A549 and HUVEC) shows the biocompatibility of the platform.Paclitaxel was used as a model drug,the distinctions of drug absorption between the mono-culture group and co-culture group were clearly observed by electrospray ionization quadrupole time-of-flight mass spectrometry(ESI-Q-TOF MS).Therefore,the integrated platform has shown promise as a high throughput,low cost for cell metabolism research and drug screening processes.

关键词： Microfluidic chip ESI-Q-TOF MS Co-culture Drug metabolism Droplet technique hydrogel microcapsule

Synthesis and Properties of IPN hydrogels Based on Konjac Glucomannan and Poly(acrylic acid)

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Chinese Chemical Letters 2006年第10期17卷 1377-1380页

作者： Bing LIU Zhi Lan LIU Ren Xi ZHUO Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University Wuhan 430072

Novel interpenetrating polymer network （IPN） hydrogels based on konjac glucomannan （KGM） and poly（acrylic acid）（PAA） were prepared by polymerization and cross-linking of acrylic acid （AA） in the pre-fabricated KGM gel. The IPN gel was analyzed by FF-IR. The studies on the equilibrium swelling ratio of IPN hydrogels revealed their sensitive response to environmental pH value. The results of in vitro degradation showed that the IPN hydrogels retain the enzymatic degradation character of KGM.

关键词： hydrogel interpenetrating polymer network pH-sensitivity konjac glucomannan poly（acrylic acid）.

Angiogenesis Induced by IKVAV-Containing Amphiphile Peptide in vivo

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Journal of Wuhan University of Technology(Materials Science) 2010年第5期25卷 803-806页

作者：宋玉林 Department of Orthopaedics the Second Affiliated Hospital of Nanchang University

An IKVAV （Isoleucine-Lysine-Valine-Alanine-Valine）-containing peptide amphiphile molecule （IKVAV-PA） was implanted subcutaneouly into rat backbone in the middle. Angiogenesis induced by IKVAV-PA was evaluated in vivo. 200 μL of 10, 2, 1 and 0.5 wt% IKVAV-PA solution were added into DMEM/F12 and self-assembled into nanofiber hydrogel. 1 mL of 1% IKVAV-PA （Experimental Group, EG） and 1 mL of 16.67% gelatin （Control Group, CG） were injected subcutaneously into rat backbone. The specimens were harvested two weeks after injection and examined immunohistochemically for VEGF（Vascular Endothelial Growth Factor）. TEM observations of hydrogels revealed a network of nanofibers, and there was a significant positive correlation between IKVAV-PA concentration and nanofiber alignment. Light microscopy observation showed capillary vessel with complete walls formed in hydrogel, with erythrocytes noted inside the vessels in EG; capillary vessels or erythrocytes were not found within gelatin in CG. Immunohistochemical analysis revealed that there were VEGF-positive cells within hydrogel, which were not found in CG. Self-assembled hydrogel from IKVAV-PA was able to induce the angiogenesis in vivo.

关键词： angiogenesis self-assembly hydrogel IKVAV-PA

Polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of cucurbiturils

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Chinese Chemical Letters 2021年第3期32卷 949-953页

作者： Yiyun Gao Yan Gao Yuanfu Ding Huaping Tan Aihua Zou Shengke Li School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Shanghai Key Laboratory of Functional Materials Chemistry State Key Laboratory of Bioreactor Engineering and Institute of Applied ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Quality Research in Chinese Medicine.Institute of Chinese Medical Sciences.University of Macao.Macao.China College of Chemistry and Materials Science Shanghai Normal University.Shanghai 200234China

With excellent biocompatibility and biodegradability,natural polysaccharides and their derivative s have exhibited great potential in constructing drug delivery ve hicles for tissue engineering and therapeutics.Cucurbit[n]uril(CB[n])-mediated reversible crosslinking of polysaccharides possess intrinsic stimuliresponsiveness towards competitive guests and have been extensively investigated to fabricate various particles and hydrogels for multiple stimuli-re sponsive drug release by incorpo ration with other stimuli including photo,redox,and enzyme.Through host-guest interactions between CB[6]and aliphatic diamines,functional tags covalently connected with CB[6]can be readily anchored into polysaccharidebased hydrogels,realizing multiple functionalization.The rheological prope rty and drug release profile of polysaccharide-based supramolecular hydrogels can be facilely tuned through CB[8]-mediated dyna mic homo or hetero crosslinking of polysaccharides and/or other polymers.In this review,we introduce and summarize recent progress regarding polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of CB[6]and CB[8],covering both bulk hydrogels and particular systems.At the end,possible utilization of CB[7]-based host-guest interactions in constructing polysaccharide-based drug delivery systems and future perspectives of this research direction are also discussed.

关键词： Cucurbit[n]uril Host-guest interaction Polysaccharides hydrogel Drug delivery Tissue engineering

Supramolecular hydrogels of self-assembled zwitterionic-peptides

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Chinese Chemical Letters 2021年第11期32卷 3636-3640页

作者： Yiming Zhang Yinghao Ding Xinxin Li Debin Zheng Jie Gao Zhimou Yang State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of Education and College of Life SciencesNankai UniversityTianjin 300071China College of Life Sciences Key Laboratory of Bioactive MaterialsMinistry of Educationand Collaboration Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology College of PharmacyTianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300071China

Zwitterionic polymer materials have been extensively studied,but zwitterionic peptides supramolecular hydrogel materials are rarely studied.In this study,the preparation of two zwitterionic hydrogels using self-assembled peptides were reported.The hydrogels could be fabricated easily by changing the temperature or enzyme catalysis in a short time.And the differences in structure and function of the zwitterion peptide hydrogels caused by the two preparation methods were also be compared.We found that the hydrogel prepared by enzyme induced self-assembly has better solubility and lower cytotoxicity than that prepared by the heating-cooling process.The result showed the enzyme induced self-assembly way to form zwitterionic peptides supramolecular hydrogel materials could have further biomedical applications.

关键词： Self-assembly hydrogel Zwitterionic-peptides Enzyme-instructed Biocompatibility

SUPER TOUGH GELS WITH A DOUBLE NETWORK STRUCTURE

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Chinese Journal of Polymer Science 2009年第1期27卷 1-9页

作者： Tasuku Nakajima Takayuki Kurokawa Hidemitsu Furukawa Yoshimi Tanaka Yoshihito Osada 龚剑萍 Department of Biological Sciences Graduate School of ScienceHokkaido University

Living tissues work with fantastic functions in soft and wet gel-like state.Thus,hydrogels have attracted much attention as excellent soft and wet materials,suitable tot making artificial organs for medical treatments.However, conventional hydrogels are mechanically too weak for practical uses.We have created double network (DN) hydrogels with extremely high mechanical strength in order to overcome this problem.DN gels are interpenetrating network (IPN) hydrogels consisting of rigid polyelectrolyte and soft...

关键词： hydrogel Toughness Fracture Necking phenomenon

Microfluidic electrospray photo-crosslinkable κ-Carrageenan microparticles for wound healing

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Engineered Regeneration

Engineered Regeneration 2021年第1期2卷 257-262页

作者： Zhiqiang Luo Junyi Che Lingyu Sun Lei Yang Yan Zu Huan Wang Yuanjin Zhao Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower HospitalNanjing University Medical SchoolNanjing 210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory Zhejiang Lab for Regenerative MedicineVision and Brain HealthWenzhouZhejiang 325001China Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325001China The Eighth Affiliated Hospital Sun Yat-sen UniversityShenzhen 518033China

When organs,especially external organs are injured,pathogens and excessive water loss can threaten the wound healing process and cause local irreversible tissue damage.Here,novel natural κ-Carrageenan microparticles(MPs)able to deliver bioactive proteins and small molecules to the wound surface for promoted regeneration were developed using microfluidic electrospray.The side chains of κ-Carrageenan were modified with methacrylate pendant groups to make the monomer photonic cross-linkable.By changing the concentration of methacrylated-κ-Carrageenan,different porosities of MPs with controllable drug loading were achieved.The size of the MPs can also be tailored by adjusting the voltage of the applied electric field.Vascular endothelial growth factor(VEGF)and antimicrobial peptides Eumenitin were co-loaded into the microparticles(VEGF-Eumenitin-MPs)and released sustainedly in phosphate-buffered saline.The VEGF-Eumenitin-MPs had high biocompatibility and intensive antibacterial activities for bacteria.Furthermore,the antibacterial and angiogenetic properties of the VEGF-Eumenitin-MPs were demonstrated in a infectious wound model and the chronic wound healing process was significantly enhanced in vivo.Therefore,the developed porous MPs with sustained drug release properties have the potential to serve as a platform to deliver bioactive proteins and small molecules to the wound surface for promoted regeneration.

关键词： Microparticle hydrogel Microfluidics Wound healing VEGF Antimicrobial peptide