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Construction of pH-Triggered DNA hydrogels Based on Hybridization Chain Reactions

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Chemical Research in Chinese Universities 2020年第2期36卷 243-246页

作者： LI Yujie CHEN Jie DONG Yuanchen LIU Huajie LIU Dongsheng Key Laboratory of Organic Optoelectronics&Molecular Engineering Ministry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084P.R.China School of Chemical Science and Engineering Shanghai Research Institute for Intelligent Autonomous SystemsKey Laboratory of Advanced Civil Engineering MaterialsMinistry of EducationTongji UniversityShanghai 200092P.R.China Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800P.R.China CAS Key Laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China

As a novel type of bio-functional material,DNA hydrogels have attracted more and more attention due to their successful applications in 3D cell culturing and tissue engineering for the designable and programmable responsiveness.Herein,we have developed a pH-triggered DNA hydrogel based on a clamped hybridization chain reaction(C-HCR).In this system,a DNA switch was designed,which can release the initiator strand in a controllable way via the formation of the C-G-C4 triplex under the pH stimuli.While the pre-gelation solution is stable in neutral environment,the C-HCR will trigger the sol-gel transition as the pH decreased to 5.0.This strategy has endowed the DNA hydrogel with good controllability for triggering,which also shows potential in intellectual responsiveness to certain stimuli.

关键词： DNA hydrogel pH-Triggered Hybridization chain reaction Sol-gel phase transition

The fabrication of hydroxyapatite mineralized hydrogels for bone tissue engineering

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Biomedical Engineering Communications 2023年第2期2卷 18-27页

作者： Xiu-Mei Zhang Jin-Qiao Jia Yu Cao Yan Wei Yin-Chun Hu Xiao-Jie Lian Zi-Wei Liang Di Huang Department of Biomedical Engineering Research Center for Nano-Biomaterials&Regenerative MedicineCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Research Center for Biomaterials Shanxi-Zheda Institute of Advanced Materials and Chemical EngineeringTaiyuan 030032China.

Bone is a complex but orderly mineralized tissue with hydroxyapatite(HA)as the inorganic phase and collagen as the organic phase.Inspired by natural bone tissues,HA-mineralized hydrogels have been widely designed and used in bone tissue engineering.HA is majorly utilized for the treatment of bone defects because of its excellent osteoconduction and bone inductivity.hydrogel is a three-dimensional hydrophilic network structure with similar properties to the extracellular matrix(ECM).The combination of HA and hydrogels produces a new hybrid material that could effectively promote osteointegration and accelerate the healing of bone defects.In this review,the structure and growth of bone and the common strategies used to prepare HA were briefly introduced.Importantly,we discussed the fabrication of HA mineralized hydrogels from simple blending to in situ mineralization.We hope this review can provide a reference for the development of bone repair hydrogels.

关键词： hydroxyapatite hydrogel mineralization bone tissue engineering

A biomass based photonic crystal made of "konjac tofu"

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Chinese Chemical Letters 2021年第1期32卷 587-590页

作者： Wenxin Zhang Min Xue Kenneth J.Shea Lili Qiu Zhibin Xu Jing Fan Dan Yan Zihui Meng School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China Department of Chemistry University of California IrvineCA 92697United States

Konjac tofu is a traditional Chinese food whose main ingredient is the water-soluble polysaccharide from konjac tubers-konjac glucomannan(KGM).Herein we report an interpenetrating double network polymeric film by crosslinking KGM and polyvinyl alcohol(PVA) with glutaraldehyde under acidic conditions.PVA was introduced into the hydrogel system as a hard skeleton,which not only maintained the biocompatibility of KGM,but also gave the hydrogel superior mechanical properties and solvent resistance.Implanting a colloidal array inside the above film,we obtained a new type of biomass based photonic crystal that is sensitive to a variety of physical and chemical stimulus,especially for methanol.This photonic crystal responds to metha nol and methanol vapo r,and has the ability to detect methanol in gasoline,which has a good application prospect.

关键词： Photonic crystals Konjac glucomannan hydrogel Interpenetrating double network Sensor

Synthesis and Characterization of Chitosan-Albumin Conjugates as pH-Sensitive Biodegradable hydrogels

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Chemical Research in Chinese Universities 2011年第2期27卷 329-333页

作者： GUO Jin-shan LI Jian-zheng JING Xia-bin CHEN Xue-si HUANG Yu-bin State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Graduate School of Chinese Academy of Sciences Beij＇ing 100049 P. R. China Department of Materials Science and Engineering Jilin University Changchun 130022 P. R. China

A new kind of biodegradable pH-sensitive drug delivery system was developed via chitosan-albumin conjugate hydrogel. Through changing the feeding modes of reactants, two types of hydrogels（comb-type and reticular-type） were synthesized by amidation reactions between 6-O-succinoylated N-phthaloyl chitosan and albumin. The structures and morphologies of the hydrogels were characterized by SEM. And their water swelling capacity, drug loading and releasing properties at different pH values were also investigated. It was found that the comb-type of hydrogels with looser space construction had better water swelling ratio（more than 400% of its original mass） than the reticular-type of ones did（about 180% of its original mass）. In vitro release experiments of Rifampicin show that the hydrogels provided the controlled release of the entrapped drug for more than 50 h. The drug release rates of both types of hydrogels under acidic condition were lower than those under neutral or basic condition. The introduction of albumin not only improved the hydrophilicity of chitosan, but also provided the possibility of the carrier system combining other biologically active materials more easily to fulfill the delivery and therapy functions.

关键词： Chitosan Albumin hydrogel pH Sensitive Drug delivery

Chitosan-g-PAA hydrogels for Colon-Specific Drug Delivery: Preparation, Swelling Behavior and in vitro Degradability

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Journal of Wuhan University of Technology(Materials Science) 2010年第2期25卷 248-251页

作者：龚时琼殷以华 School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Department of Pharmaceutical Engineering School of Chemistry Engineering Wuhan University of Technology

A series of cross-linked hydrogels for colon-specific drug delivery were synthesized by graft copolymerization of Chitosan and acrylic acid using N, N＇-methylene-bis-（acrylamide） as a cross-linker. Their swelling behavior in different pH buffer solutions and colonic enzymatic degradability were studied. The obtained results show that these hydrogels have good pH sensitivity which can avoid drug release in stomach, and their swelling kinetics in stimulant intestinal environment follow second-order swelling kinetics equation. The factors influencing the swelling kinetics include the degree of cross-linking and the composition, which may control no release or a little amount release of drug inside the hydrogels in the small intestine by tailoring these factors. The gels are degradable by colonic enzymes and there is a correlativity between the degradation of networks and the swelling degree of the gels, which may trigger the release of drug in the colon. The hydrogels show a great potential for their application in oral colon-specific drug delivery system.

关键词： hydrogel pH sensitivity swelling behavior colonic enzymatic degradability colon-specific drug delivery

Development ofκ-carrageenan hydrogels with mechanically stronger structures via a solvent-replacement method

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Food Innovation and Advances 2023年第4期2卷 313-323页

作者： Yichuan Wang Xinna Zhang Yanxiang Gao Fang Yuan Like Mao College of Food Science&Nutritional Engineering China Agricultural UniversityBeijing 100083China Quality and Safety&Risk Assessment for Agri-Products Laboratory of Storage and PreservationBeijing 100083China

Strongκ-carrageenan(KC)hydrogels were fabricated via solvent replacement with sorbitol,and the effects of KC mass fraction and solvent replacement on the structural characteristics encapsulation capability of the hydrogels were evaluated.Microstructural observation showed that the 3D network structures of hydrogels exhibited a complete and continuous skeleton.FTIR spectra of KC hydrogels revealed the formation of intermolecular hydrogen bonds after sorbitol replacement.The stability against heating and freeze-thawing of hydrogels was enhanced due to the addition of sorbitol and the rise in KC mass fraction.The hydrogel with 1.5 wt%KC after sorbitol replacement presented the best stability.Frequency sweep tests suggested that storage modulus of the samples were influenced by sorbitol replacement and KC concentration.Swelling tests revealed that the hydrogels after replacement with a higher KC content(1.25,1.50 wt%)presented higher swelling capacity,and they were more stable in alkaline and acidic solutions.When epigallocatechin gallate(EGCG)was incorporated within the hydrogels,the hydrogels after sorbitol replacement offered higher protection capability.The information obtained in this study indicated that sorbitol replacement strengthened KC hydrogels,and they could act more appropriately as accountable carriers for bioactives.

关键词： stability. hydrogel bonds

Characterization of UV-curable Poly（ethylene glycol） Diacrylate Based hydrogels

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Chemical Research in Chinese Universities 2015年第6期31卷 1046-1050页

作者： QIN Xuzhen HU Qianqian GAO Guanghui GUAN Shuang School of Chemistry and Life Science Advanced Institute of Materials Science Changchun University of Technology Changchun 130012 P. R. China

Poly（ethylene glycol） diacrylate/polyvinyl alcohoI（PEGDA/PVA） hydrogels were prepared from PEGDA and PVA as precurors by means of single UV radiation（UV ra.）, UV radiation followed by high energy electron beam irradiation（Irra.）, UV radiation followed by freeze-thawing（FT） or UV ra. and Irra. followed by FT, respectively. 2-Hydroxy-l-[4-（hydroxyethoxy）phenyl]-2-methyl-l-propanone（Irgacure 2959） was used as a photoinitiator. The effects of the various methods on the swelling and mechanical properties of the hydrogels were investigated. The results show that hydrogels made by UV ra. plus high energy electron beam irradiation followed by FT showed a higher crosslinking density and a larger tensile strength than those made by the other methods.

关键词： Poly（ethylene glycol） diacrylate Polyvinyl alcohol hydrogel UV radiation

Stimuli-Responsive Polypeptide-Based Supramolecular hydrogels Mediated by Ca^2+ Ion Cross-Linking

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Chinese Journal of Chemistry 2019年第11期37卷 1137-1141页

作者： Fandong Meng Jing Sun Zhibo Li Key Laboratory of Biobased Polymer Materials Shandong Provincial Education DepartmentSchool of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdaoShandong 266042China

Background and Originality Content hydrogels,which retain a large amount of water,possess tunable porous three-dimensional nanostructure.They are known to resemble human tissue that can offer many advantages in biomedical applications such as tissue engineering,drug delivery and surgical dressings.1141 Stimuli-responsive hydrogels,referred as smart hydrogels can rapidly respond in a controlled manner to external stimuli,such as temperature,pH,light,etc.[s]In particular,the thermal-responsive hydrogels exhibit sol-to-gel phase transition upon heating up to lower critical gelation temperatures(CGTs).

关键词： hydrogel critical porous

PVA/PEG Hybrid hydrogels Prepared by Freeze-thawing and High Energy Electron Beam Irradiation

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Chemical Research in Chinese Universities 2017年第6期33卷 995-999页

作者： ZHAO Chunming LU Xueting HU Qianqian LIU Shuai GUAN Shuang School of Chemistry and Life Science Advanced lnst#ute of Materials Science Changchun University of Technology Changchun 130012 P. R. China

In this paper, poly（vinyl alcohol）（PVA） and PVA/poly（ethylene glycol）（PEG） hybrid hydrogels were synthesized by freeze-thawing or freeze-thawing followed by high energy electron beam irradiation. The influence of PEG molecular weight, mass ratios of PVA to PEG, thawing temperature and number of freeze-thawing（FT） cycles on the mechanical strength of PVA/PEG hydrogel was investigated. Also, the thermal behaviors were examined by differential scanning calorimetry（DSC） and the microstructttres were observed with scanning electron microscopy（SEM）. The results suggest that the addition of PEG improves the mechanical strength of PVA hydrogel and the irradiation reduces both the strength of PVA/PEG hydrogel slightly and the degree of crystallinity. The improved properties suggest that PVA/PEG hydrogel can be a good candidate for the application in the biomedical.

关键词： Poly（vinyl alcohol） Poly（ethylene glycol） High energy beam irradiation Freeze-thawing hydrogel