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Peroxisome proliferator-activated receptor a agonist attenuates oxidized-low density lipoprotein induced immune maturation of human monocyte-derived dendritic cells

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Chinese Medical Journal 2008年第17期121卷 1747-1750页

作者： SHI Hong-yu GE Jun-bo FANG Wei-yi YAO Kang SUN Ai-jun HUANG Rong-chong JIA Qing-zhe WANG Ke-qiang ZOU Yun-zeng CAO Xue-tao Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan University Shanghai 200032 China Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai 200030 China Institute of Immunology Second Military Medical University Shanghai 200433 China

Accumulating evidence suggests that the Thl immune .response induced by various antigens such as oxidized low density lipoprotein （ox-LDL） and heat shock proteins （HSPs） play a key role in the process of atherosclerosis.1dendritic cells （DCs） are the most potent antigen-presenting cells （APCs） in the body with the unique ability to initiate a primary immune response to certain antigens by the activation of ＂naive＂ T cells.2 The maturation of DC with the upregulation of costimulatory molecules such as CD83, CD40, CD86, and major histocompatibility complex （MHC） class molecules such as human leukocyte antigen （HLA）-DR, is required for DC to activate T cells. Pathologic studies have shown that immature DCs are present in normal arterial while abundant mature DCs clustered with T cells could be visualized in atherogenic vessels suggesting that DC 3 maturation is linked to the progression of atherosclerosls. Peroxisome proliferator-activated receptors （PPARs） a, one member of the family of PPARs, was found to have favorable effects on slowing the progression of atherosclerosis and reducing the risk of coronary heart disease in high-risk patients independent from their metabolism effects.4＇5 Furthermore, PPAR-α is also expressed on monocytes and monocyte-derived DCs.6 The effects of PPAR-α on DCs maturation and immune function remain unknown now, we therefore observed the effects of fenofibrate, a PPAR-α agonist, on the maturation and immune function of oxidized LDL-treated DCs in this study.

关键词： human monocyte-derived dendritic cells atherosclerosis oxidized-low density lipoprotein peroxisomeproliferator-activated receptors a

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