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Characterization of human metapneumovirus from pediatric patients with acute respiratory infections in a 4-year period in Beijing, China

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Chinese Medical Journal 2011年第11期124卷 1623-1628页

作者： ZHU Ru-nan QIAN Yuan ZHAO Lin-qing DENG Jie SUN Yu WANG Fang LIAO Bin LI Yan HUANG Rong-yan Laboratory of Virology Peking University Capital Institute ofPediatrics Teaching Hospital Beijing 100020 China Laboratory of Virology Capital Institute of Pediatrics Beijing100020 China Affiliated Children's Hospital to Capital Institute of Pediatrics Beijing 100020 China Influenza and Respiratory Viruses Section National MicrobiologyLaboratory Public Health Agency of Canada Winnipeg R3E3R2Canada

Background human metapneumovirus （hMPV） was discovered by scientists in the Netherlands as a novel respiratory virus in 2001 and had been found in children with acute respiratory tract infections （ARTI） in China. The objective of this study was to determine the importance of hMPV infection in children in Beijing and the genotypes of the circulating virus by the surveillance during a four-consecutive-year period.

关键词： human metapneumovirus surveillance respiratory infection children

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The Prevalence of human metapneumovirus among Children with Acute Respiratory Tract Infection in North Kordofan State, Sudan

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American Journal of Molecular Biology 2020年第4期10卷 259-264页

作者： Huzifa Abdalla Abdelrahman Ahmed Nassreldeen Khalid Abdelrahman Mudathir Abdallah Adam Faculty of Medicine Sudan International University Khartoum Sudan Faculty of Medical Laboratory Science University of Al Fashir Al Fashir Sudan

Objective: To determine the prevalence of human metapneumovirus (hMPV) among children with acute respiratory tract infection and the correlation between (hMPV) and age group. Methods: This prospective, descriptive cross-sectional hospital-based study is carried out from January to May 2019 among children from under five years old who were admitted to El-Obeid pediatric teaching Hospital, North kordofan, Sudan with acute respiratory tract infection. Results: Fifty hospitalized children with acute respiratory tract infection were enrolled in the study. Two of these (4%) were tested positive for (hMPV) in the age group (7 months - 2 years) old. Moreover, the study showed no significant correlation between infection with (hMPV) and age.

关键词： human metapneumovirus Respiratory Tract Infection Real Time Sudan

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In vitro and in vivo anti-HMPV activity of JH001 isolated from Chinese medicinal herbs

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中国药理学与毒理学杂志 2021年第10期35卷 733-733页

作者： LI Jin-hua ZHAO Yao DAI Ying ZHAO Jun-ning West China School of Pharmacy Sichuan University Chengdu 610041China Sichuan Academy of Chinese Medicine Sciences Chengdu 610041China Sichuan Institute for Translational Chinese Medicine Chengdu 610041China Children′s Hospital of Chongqing Medical University Chongqing 400014China

OBJECTIVE human metapneumovirus(hMPV)is semblable to respiratory syncytial virus(RSV)which causes respiratory infections typically characterized by cough,runny nose,fever,and nasal congestion but sometimes progressing to bronchiolitis and ***,there is no corresponding drug to inhabit the *** of new compounds with potential anti-HMPV activity could produce clinical *** herbal medicine played a great role during COVID-19,therefore we choose some small molecular(JH001)extracted from botany to investigate therapeutic effect on hMPV and the underlying *** In this study,16HBE cells were used as a model to explore in vitro antiviral *** assays were performed before the antiviral tests,cell viability of 16HBE cells handled by different concentration of JH001 was estimated by Cell Counting Kit-8(CCK-8).Then RT-qPCR,immunofluorescence,and flow cytometer were used to test the viral titer after cells infected with ***,6-8 weeks mice were infected intranasally with 60μL of hMPV,the control group was treated with 0.9%saline water,other groups were administered with JH001 and ribavirin,then the lung virus titer and protective effect in lung were *** The obtained JH001 exhibited no cytotoxicity to 16HBE cells during 6.25-200μmol·L^(-1).RT-QPCR demonstrated that JH001 showed obvious inhabitation to the viral replication and showed great significance compared with *** fluorescence exhibited distinct decrease of hMPV-N protein,flow cytometer results showed that MFI decrease *** reduction of N-gene expression was observed in those mice treated with JH001 compared with saline group,which indicated that JH001 probably had protective and therapeutic effect on viral *** This study illustrated that JH001 might be a promising option for small molecular against hMPV and JH001 might be worthy of further development and used as a potential therapeutic strategy for

关键词： human metapneumovirus Chinese herbal medicine antiviral activity respiratory infections

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