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Novel Tumor-infiltrating CD39+ γδ Tregs Are the Predominant Immunosuppressive T Cells in human Colorectal Cancer that Facilitate Tumor Progression

Novel Tumor-infiltrating CD39+ γδ Tregs Are the Predominan...

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浙江省免疫学会第十次学术大会

作者： Guoming Hu Pin Wu Pu Cheng Zhen Wang Xiuyan Yu Xuan Shao Dang Wu Jun Ye Tao Zhang Xiaochen Wang Fuming Qiu Jun Yan Jian Huang Cancer Institute(Key Laboratory of Cancer Prevention & Intervention National Ministry of Education Provincial Key Laboratory of Molecular Biology in Medical Sciences) Zhejiang University School of Medicine Department of Radiation Oncology Zhejiang University School of Medicine Department of Gastroenterology Second Affiliated HospitalZhejiang University School of Medicine Department of Medicine and Department of Microbiology and Immunology James Graham Brown Cancer CenterUniversity of Louisville

Background:Tumor microenvironment promotes immune suppression through recruiting and expanding suppressive immune cells such as regulatory T cells(Tregs) to facilitate cancer ***4+ Tregs are considered as the major immunosuppressive T cells in many cancers including human colorectal cancer(crc).However,this conclusion is not definitive as most of those studies did not extensively examine the whole suppressive T cell *** fact,the role of CD4+Tregs in crc is controversial in terms of their prognostic ***,it is drastically needed to understand the exact role of those regulatory T cells in human *** regulatory T cells are heterogeneous population,it is tempting to speculate that there may be another immunosuppressive T cell population that plays a pivotal role in facilitating crc progression and immune *** previous studies have demonstrated that innate IL-17-producing γδT cells(γδT17)could recruit and expand polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs) in the tumor that inhibit effector T cell function and establish an immunosuppressive microenvironment thus promoting crc progression,suggesting that γδT cell subpopulation exhibited specific significance in immune regulation of human colorectal *** research showed that approximately 50%of tumor-infiltrating γδT cells expressed high levels of CD39 ***39+ γδT cells were significantly increased in the tumor tissues compared to the paired normal *** a few model studies have unraveled that CD39+ γδT cells could in vitro inhibit CD3+ T cell proliferation,implicating CD39 is a specific marker of γδ***,based on our previous findings,we believe that human crc-infiltrating CD39+γδT cells are likely to be a novel immunosuppressive *** preliminary functional assay shows that tumor-infiltrating CD39+ γδT cells conventional CD4+ Tregs and paired normal tissue sourced CD39+ γδT *** suggests tumor-infiltrating CD39+ γδT cells

关键词： CD39+γδTregs tumor-derived TGF-β1 adenosine human crc

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