检索结果-南通市图书馆

human herpesvirus 6A induces apoptosis of HSB-2 cellsvia a mitochondrion-related caspase pathway

The Journal of Biomedical Research 2010年第6期24卷 444-451页

作者： Lingyun Li Jing Chi Feng Zhou Dandan Guo Fang Wang Genyan Liu Chun Zhang Kun Yao Department of Microbiology and Immunology Nanjing Medical UniversityNanjingJiangsu 210029China Department of Developmental Genetics Nanjing Medical UniversityNanjingJiangsu 210029China Department of Laboratory Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Apoptosis plays an important role in the pathogenesis of viral *** this study,we investigated the cell death processes during productive HHV-6A infection and the underlying *** V-PI staining and electron microscopy indicated that HHV-6A is a strong inducer of ***-6A infection decreased mitochondrial transmembrane potential and led to morphological changes of *** cell death was associated with activation of caspase-3 and cleavage of DNA repair enzyme poly （ADP-ribose） polymerase,which is known to be an important substrate for activated ***-9 was activated significantly in HHV-6A-infected cells,whereas caspase-8 was not activated ***,HHV-6A infection upregulated Bax and downregulated *** is the first demonstration of mitochondrion-mediated,caspase-dependent apoptosis in HHV-6A-infected cells.

关键词： human herpesvirus 6 apoptosis caspase mitochondrion-mediated

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology

引用

Neural Regeneration Research 2018年第2期13卷 211-221页

作者： Jessica M.Hogestyn David J.Mock Margot Mayer-Proschel Department of Neuroscience University of Rochester Department of Biomedical Genetics University of Rochester

human herpesviruses （HVs） have developed ingenious mechanisms that enable them to traverse the defenses of the central nervous system （CNS）. The ability of HVs to enter a state of latency, a defining char- acteristic of this viral family, allows them to persist in the human host indefinitely. As such, HVs represent the most frequently detected pathogens in the brain. Under constant immune pressure, these infections are largely asymptomatic in healthy hosts. However, many neurotropic HVs have been directly connected with CNS pathology in the context of other stressors and genetic risk factors. In this review, we discuss the potential mechanisms by which neurotropic HVs contribute to neurodegenerative disease （NDD） patholo- gy by highlighting two prominent members of the HV family, herpes simplex virus 1 （HSV-1） and human herpesvirus 6 （HHV-6）. We （i） introduce the infectious pathways and replicative cycles of HSV-1 and HHV-6 and then （ii） review the clinical evidence supporting associations between these viruses and the NDDs Alzheimer＇s disease （AD） and multiple sclerosis （MS）, respectively. We then （iii） highlight and dis- cuss potential mechanisms by which these viruses exert negative effects on neurons and glia. Finally, we （iv） discuss how these viruses could interact with other disease-modifying factors to contribute to the initiation and/or progression of NDDs.

关键词： herpes simplex virus 1 human herpesvirus 6 central nervous system neurodegeneration demyelination Alzheimer's disease multiple sclerosis viral latency viral reactivation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

human herpesvirus 6 Infection Complicated by Viral Encephalitis Following Liver Transplantation:A Case Report

引用

Infectious Microbes & Diseases 2024年第3期6卷 158-161页

作者： Kai Kou Heyu Huang Wei Qiu Yuguo Chen Xiaodong Sun Guoyue Lv General Surgery Center Department of Hepatobiliary and Pancreatic SurgeryThe First Hospital of Jilin University:Bethune First Hospital of Jilin UniversityChangchunChina

human herpesvirus 6(HHV-6)is a significant pathogen following solid organ ***,we report a 64-year-old female with cirrhosis related to nonalcoholic fatty liver disease who underwent orthotopic allogeneic liver transplantation and was ultimately diagnosed with HHV-6 encephalitis through cerebrospinal fluid analysis and *** treatment with daily ganciclovir was initiated according to characteristics indicative of viral encephalitis 3 days before confirmed *** improvement in symptoms was observed,with clearance of HHV-6 from the *** complex diagnosis and management of this case accentuate the possibility of serious consequences of HHV-6 infection in postoperative liver transplant *** must maintain a high index of suspicion for HHV-6 reactivation,especially given its association with immunosuppressive drug *** recognition and initiation of antiviral therapy are paramount,particularly when patients present with fever or psychiatric symptoms,as these may indicate HHV-6 encephalitis.

关键词： human herpesvirus 6 viral encephalitis liver transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

DETECTION OF human herpesvirus 6(HHV-6) DNA IN SALIVARY GLANDS BY THE POLYMERASE CHAIN REACTION

引用

Chinese Medical Sciences Journal 1997年第2期12卷 126-128页

作者：赵继志范宏宇沐桂藩沈晓东程效东 Department of Stomatology Peking Union Medical College Hospital CAMS & PUMC Beijing 100730 Department of Microbiology and Immunology Institute of Basic Medical SciencesCAMS&PUMCBeijing 100005

To assess the presence of HHV-6-Specific DNA in human salivary glands, eighteen specimens of salivary gland tissue were investigated using the polymerase chain reaction. Eight of nine parotid glands, five of seven submandibular glands and one of two sublingual glands were found to have amplification of the HHV-6-specific sequence. The findings suggest that salivary gland tissue is one of the potential sites for HHV-6 persistence following primary infection and that saliva is a vehicle for transmission of the virus.

关键词： human herpesvirus 6 salivary gland polymerase chain reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Isolated ileal perforation due to cytomegalovirus reactivation during management of terbinafine hypersensitivity

引用

World Journal of Gastroenterology 2010年第26期16卷 3339-3342页

作者： Soichi Sano Hiroki Ueno Keiko Yamagami Yosuke Yakushiji Yoshihiro Isaka Isao Kawasaki Masashi Takemura Takeshi Inoue Masayuki Hosoi Department of Internal Medicine Osaka City General Hospital Osaka 534-0021 Japan Department of Metabolism and Endocrinology Osaka City General Hospital Osaka 534-0021 Japan Department of Gastrointestinal Surgery Osaka City General Hospital Osaka 534-0021 Japan Department of Pathology Osaka City General Hospital Osaka 534-0021 Japan

We report a case of 71-year-old man who developed a hypersensitivity syndrome associated with terbinafine. He was placed on terbinafine (250 mg/d) for the treatment of tinea pedis due to diabetes mellitus. Following the treatment with terbinafine, he developed druginduced hypersensitivity syndrome (DIHS). Systemic corticosteroid led to transient improvement of his clinical manifestations. Three months after disease onset, he presented with panperitonitis due to ileal perforation, and underwent an emergency operation. The affected ileum was resected and ileostomy was performed in the terminal ileum. Cytomegalovirus (CMV)-specific IgG antibodies were significantly increased, high-titer CMV antigenemia was detected, and pathological examination of the resected ileum confirmed CMV infection. Based onthese observations, we strongly recommend that physicians monitor reactivation of the family of herpesvirus other than herpesvirus 6, to manage DIHS properly.

关键词： Terbinafi ne Drug hypersensitivity human herpesvirus 6 Cytomegalovirus Intestinal perforation Ileum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：