检索结果-南通市图书馆

检索条件"主题词=hsa-miR-320b"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

The combination of NDUFS1 with immune infiltration predicts favorable prognosis in kidney renal clear cell carcinoma

The combination of NDUFS1 with immune infiltration predicts ...

引用

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青...

作者： Dong Wu Zhe Xu Ling Li The Fourth Military Medical University

Purpose: Kidney renal clear cell carcinoma(KIRC), the most common malignant tumor of the urinary system, is an immunogenic tumor, and KIRC patients therapeutic response and prognosis are relevant to immune infiltration. NDUFS1, the core subunit of mitochondria complex I(CI) in the respiratory chain, participating in the procedure of electron transport has been reported to be associated with the occurrence and development of tumors and be down-regulated in KIRC and associated with poor prognosis. However, the upstream regulator for NDUFS1 and their correlations with immune infiltration or patients survival remain unclear. Here, we tried to elucidate the immunological mechanism and clinical significance of NDUFS genes in KIRC.Methods: The expression of NDUFS genes in KIRC and their influences on patients survival were investigated by UALCAN, ENCORI(The Encyclopedia of RNA Interactomes), GEPIA(Gene Expression Profiling Interactive Analysis), Oncomine, TIMER(Tumor Immune Estimation Resource site) and Kaplan-Meier Plotter. mir NAs regulating NDUFS1 in KIRC were predicted and analyzed by TargetScan and ENCORI. The correlations between NDUFS1 or mirNAs expression with immune cell infiltration or gene marker sets of immune infiltrates were analyzed via TIMER. The overall survival curves in high/low NDUFS1 or high/low hsa-mir-320 b expressed KIRC patients based on immune infiltration were analyzed via Kaplan-Meier Plotter.Results: From comprehensive bioinformatic analysis through digging into public online databases, we consistently found that in NDUFS gene family, NDUFS1 was significantly down-regulated in KIRC,high expression of NDUFS1, NDUFS4 predict good overall survival(OS) prognosis, and high expression of NDUFS1, NDUFS2, and NDUFS4 are correlated with good disease-free survival(DFS)prognosis. Moreover, the expression of NDUFS1 negatively correlates with advanced tumor grades and individual cancer stages, demonstrating that NDUFS1 may serve as a tumor suppressor gene in KIRC. NDUFS1 expression was positively correla

关键词： kidney renal clear cell carcinoma NDUFS1 survival expression immune infiltration hsa-mir-320b

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：