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Multi-scale analysis of schizophrenia risk genes, brain structure, and clinical symptoms reveals integrative dues for subtyping schizophrenia patients

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Journal of Molecular Cell Biology 2019年第8期11卷 678-687页

作者： Liang Ma Edmund T.Rolls Xiuqin Liu Yuting Liu Zeyu Jiao Yue Wang Weikang Gong Zhiming Ma Fuzhou Gong Lin Wan CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100101 China National Center of Mathematics and Interdisciplinary Sciences Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China Department of Computer Science University of Warwick Coventry CV4 7AL UK Oxford Centre for Computational Neuroscience Oxford 0X2 7JF UK School of Mathematics and Physics University of Science and Technology Beijing Beijing 100083 China School of Science Beijing Jiaotong University Beijing 100044 China Centre for Computational Systems Biology School of Mathematical Sciences Fudan University Shanghai 200433 China CAS-MPG Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China University of Chinese Academy of Sciences Beijing 100049 China

Analysis Unking directly genomics, neuroimaging phenotypes and clinical measurements is crucial for understanding psychiatric disorders, but remains rare.Here, we describe a multi-scale analysis using genome-wide SNPs, gene expression, grey matter volume (GMV), and the positive and negative syndrome scale scores (PANSS) to explore the etiology of schizophrenia. With 72 drug-naive schizophrenic first episode patients (FEPs) and 73 matched heathy controls, we identified 108 genes, from schizophrenia risk genes, that correlated significantly with GMV, which are highly co-expressed in the brain during development. Among these 108 candidates, 19 distinct genes were found associated with 16 brain regions referred to as hot clusters (HCs), primarily in the frontal cortex, sensory-motor regions and temporal and parietal regions.The patients were subtyped into three groups with distinguishable PANSS scores by the GMV of the identified HCs. Furthermore, we found that HCs with common GMV among patient groups are related to genes that mostly mapped to pathways relevant to neural signaling, which are associated with the risk for schizophrenia.Our results provide an integrated view of how genetic variants may affect brain structures that lead to distinct disease phenotypes.The method of multi-scale analysis that was described in this research, may help to advance the understanding of the etiology of schizophrenia.

关键词： Schizophrenia PANSS multi-scale analysis hot cluster grey matter volume pathway

Crystallization behavior of blast-furnace slag by single hot thermocouple technique

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Journal of Iron and Steel Research(International) 2020年第3期27卷 259-265页

作者： Tie-lei Tian Shuang Cai Yu-zhu Zhang Hong-wei Xing College of Metallurgy and Energy North China University of Science and TechnologyTangshan 063009HebeiChina College of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina

The crystallization behavior of blast-furnace slag under isothermal and continuous-cooling conditions was studied using the single hot thermocouple technique.The crystallization phases were obtained using FactSage software and X-ray diffractometry.The crystallization kinetic parameters were calculated by combining these results with the Johnson-Mehl—Avrami model.Under isothermal conditions,the shortest crystallization incubation time was 24 and 18 s when the temperatures were 1300 and 1150℃,and the corresponding critical cooling rates were 4.5 and 14.3℃/s,respectively.At 1270℃,the slag was difficult to crystallize and the fiber-forming rate improved.When the continuous-cooling rate was 6.5℃/s,the slag solidified into a glassy state.The main crystallization phases,gehlenite,akermanite,anorthite,and melangite,were most easily precipitated.The growth factors of melangite and anorthite were approximately 1.63 and 1.68,respectively,which indicated that the crystals nucleated on the surface and grew in two dimensions.

关键词： Blast-furnace slag Cooling rate Crystallization Single hot thermocouple technique

Dynamic matrix predictive control for a hydraulic looper system in hot strip mills

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Journal of Central South University 2017年第6期24卷 1369-1378页

作者：尹方辰孙杰彭文王鸿雨杨晶张殿华 State Key Laboratory of Rolling and Automation(Northeastern University) Shenyang 110819China

Controlling the looper height and strip tension is important in hot strip mills because these variables affect both the strip quality and strip threading. Many researchers have proposed and applied a variety of control schemes for this problem, but the increasingly strict market demand for strip quality requires further improvements. This work describes a dynamic matrix predictive control(DMC) strategy that realizes the optimal control of a hydraulic looper multivariable system. Simulation experiments for a traditional controller and the proposed DMC controller were conducted using MATLAB/Simulink software. The simulation results show that both controllers acquire good control effects with model matching. However, when the model is mismatched, the traditional controller produces an overshoot of 32.4% and a rising time of up to 2120.2 ms, which is unacceptable in a hydraulic looper system. The DMC controller restricts the overshoot to less than 0.08%, and the rising time is less than 48.6 ms in all cases.

关键词： hot strip mill hydraulic looper system mathematical model dynamic matrix predictive control

Physical-based constitutive model considering the microstructure evolution during hot working of AZ80 magnesium alloy

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Advances in Manufacturing 2019年第1期7卷 30-41页

作者： Ze-Xing Su Chao-Yang Sun Ming-Wang Fu Ling-Yun Qian School of Mechanical Engineering University of Science and Technology Beijing Beijing 100083 People's Republic of China Beijing Key Laboratory of Lightweight Metal Forming Beijing 100083 People's Republic of China Department of Mechanical Engineering The Hong Kong Polytechnic University Hung Hom Hong Kong People's Republic of China

A physical-based constitutive model was developed to model the viscoplastic flow behavior and microstructure evolution of AZ80 magnesium alloy during the hot working process. The competing deformation mechanisms, including work hardening, dynamic recovery, and dynamic recrystallization, in an isothermal compression environment were considered in the model. The internal state variables, including the normalized dislocation density and recrystallized volume fraction, were incorporated into the model to articulate the microstructure evolution during hot deformation. The kinetic condition critical for dynamic recrystallization, considering the effects of the deformation temperature and strain rate, was obtained by employing both the Poliak-Jonas criterion and Zener-Hollomon parameter. Microstructure observations indicate that the recrystallized volume fraction increases with decreasing Z parameter at constant strain, which is consistent with the predicted kinetics model. Based on the developed model, a good correlation was also obtained between the predicted and experimental flow stress. The results indicate a good predictability of the model in describing the hot deformation behavior and microstructure evolution of AZ80 magnesium alloy.

关键词： AZ80 magnesium alloy hot deformation Constitutive model Microstructure evolution Dynamic recrystallization (DRX)

Integrated Extrusion-Shear Forming Process of the Solid-State Recycled AZ80 Magnesium Alloy via hot Press Sintering

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Acta Metallurgica Sinica(English Letters) 2020年第3期33卷 351-361页

作者： Bing Li Bugang Teng Baoting Zhang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China National Key Laboratory for Precision hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China

The consolidation recycled AZ80 billets were successfully fabricated through the cold press and hot press sintering of the AZ80 metal chips.The consolidation recycled billets sintered at 350℃present the comparable compressive properties and inferior tensile properties compared with the initial cast billets.The defects in the consolidation recycled billet were inclined to propagate along the bond interface between the metal chips during tension,which resulted in the inferior tensile properties of the recycled billets.The recycled billets were then subjected to the integrated extrusion-shear(ES) process.The homogeneous finer dynamic recrystallization grains with an average grain size of 6 μm can be obtained in the shear deformation zone and extrusion sizing zone through integrated ES process at 300℃with an extrusion velocity of 0.6 mm/s.The recycled billets after integrated ES forming process present rival tensile properties compared with the initial cast billets after integrated ES forming with the same extrusion parameters,which can be ascribed to that the integrated ES forming can nearly eliminate the defects through the severe compressive and shear strain.The solid-state recycling process through hot press sintering and subsequent integrated ES process can fabricate the consolidation recycled AZ80 rod,which demonstrates the comparable tensile properties with the cast-extrusion rod.

关键词： Solid-state recycling hot press sintering Integrated extrusion-shear forming Metal chips Mechanical properties

Mapping theme trends and knowledge structures for human neural stem cells:a quantitative and co-word biclustering analysis for the 2013-2018 period

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Neural Regeneration Research 2019年第10期14卷 1823-1832页

作者： Wen-Juan Wei Bei Shi Xin Guan Jing-Yun Ma Ya-Chen Wang Jing Liu Stem Cell Clinical Research Center the First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina National Joint Engineering Laboratory the First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Department of Physiology China Medical UniversityShenyangLiaoning ProvinceChina

Neural stem cells,which are capable of multi-potential differentiation and self-renewal,have recently been shown to have clinical potential for repairing central nervous system tissue damage.However,the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically.In this study,we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.Co-word analysis was conducted to statistically quantify the characteristics and popular themes of human neural stem cell-related studies.Bibliographic data matrices were generated with the Bibliographic Item Co-Occurrence Matrix Builder.We identified 78 high-frequency Medical Subject Heading(MeSH)terms.A visual matrix was built with the repeated bisection method in gCLUTO software.A social network analysis network was generated with Ucinet 6.0 software and GraphPad Prism 5 software.The analyses demonstrated that in the 6-year period,hot topics were clustered into five categories.As suggested by the constructed strategic diagram,studies related to cytology and physiology were well-developed,whereas those related to neural stem cell applications,tissue engineering,metabolism and cell signaling,and neural stem cell pathology and virology remained immature.Neural stem cell therapy for stroke and Parkinson’s disease,the genetics of microRNAs and brain neoplasms,as well as neuroprotective agents,Zika virus,Notch receptor,neural crest and embryonic stem cells were identified as emerging hot spots.These undeveloped themes and popular topics are potential points of focus for new studies on human neural stem cells.

关键词： nerve regeneration human neural stem cells PubMed bibliometric analysis biclustering analysis co-word analysis strategic diagram analysis social network analysis hot research topics mapping theme trends knowledge structures neural regeneration

Tempering stability of Fe–Cr–Mo–W–V hot forging die steels

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International Journal of Minerals,Metallurgy and Materials 2017年第10期24卷 1145-1157页

作者： Yuan-ji Shi Xiao-chun Wu Jun-wan Li Na Min School of Materials Science and Engineering Shanghai University Shanghai 200072 China

The tempering stability of three Fe–Cr–Mo–W–V hot forging die steels(DM, H21, and H13) was investigated through hardness measurements and transmission electron microscopy(TEM) observations. Both dilatometer tests and TEM observations revealed that DM steel has a higher tempering stability than H21 and H13 steels because of its substantial amount of M_2C(M represents metallic element) carbide precipitations. The activation energies of the M_2C carbide precipitation processes in DM, H21, and H13 steels are 236.4, 212.0, and 228.9 kJ/mol, respectively. Furthermore, the results indicated that vanadium atoms both increase the activation energy and affect the evolution of M_2C carbides, resulting in gradual dissolution rather than over-aging during tempering.

关键词： tempering stability hot forging die steels carbide precipitation

hot PRESSING AND ITS DEFORMATION MECHANISM OF Ag-SHEATHED DPSCCO SUPERCONDUCTING TAPES

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中国有色金属学会会刊：英文版 1998年第1期8卷 89-92页

作者： Ma, Yanwei Wang, Xianjin Wang, Zutang Univ of Science and Technology Beijing Beijing China

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关键词： Ag-sheathed superconducting tapes hot pressing deformation mechanismcritical current density

Powder Size Influence on Tensile Properties and Porosity for PM Ti2AlNb Alloy Prepared by hot Isostatic Pressing

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Acta Metallurgica Sinica(English Letters) 2019年第11期32卷 1329-1336页

作者： Zheng-Guan Lu Jie Wu Lei Xu Rui Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Pre-alloyed powder of Ti2AlNb alloy was prepared by electrode induction gas atomization method, and the powder was screened into fi ve kinds of powder size distribution. Fully dense Ti2AlNb alloy was prepared by powder metallurgy(PM) using hot isostatic pressing. The properties of pre-alloyed powder and PM Ti2AlNb alloy were tested. Results show that mean grain size of PM Ti2AlNb alloy is infl uenced by powder particle size, but particle size has no signifi cant infl uence on tensile properties. Finer Ti2AlNb powder has low Argon gas bubble ratio and high oxygen content, and poor fl owability of fi ner powder increases the degree of diffculty during degassing. As a result, big pores(> 50 μm) are observed in PM Ti2AlNb alloy prepared by fi ner powder and cause plasticity loss of tensile properties. In order to get a better comprehensive properties of PM Ti2AlNb alloy, powder with an average size(~ 100 μm) is suggested.

关键词： Ti2AlNb alloy Powder metallurgy Powder size distribution hot isostatic pressing