检索结果-南通市图书馆

Quantitative prediction of the bitterness of atomoxetine hydrochloride and taste-masked using hydroxypropyl-β-cyclodextrin:A biosensor evaluation and interaction study

引用

Asian Journal of Pharmaceutical Sciences 2020年第4期15卷 492-505页

作者： Shuying Li Ying Zhang Abdur Rauf Khan Shuwang He Yingxin Wang Jiangkang Xu Guangxi Zhai Department of Pharmaceutics College of PharmacyShandong UniversityJinan250012China Department of Pharmaceutical Development Shandong Dyne Marine Biopharmaceutical Limited CorporationRongcheng264300China

The bitterness of a drug is a major challenge for patient acceptability and compliance,especially for *** to the toxicity of medication,a human taste panel test has certain *** hydrochloride(HCl),which is used for the treatment of attention deficit/hyperactivity disorder(ADHD),has an extremely bitter *** aim of this work is to quantitatively predict the bitterness of atomoxetine HCl by a biosensor *** on the mechanism of detection of the electronic tongue(Etongue),the bitterness of atomoxetine HCl was evaluated,and it was found that its bitterness was similar to that of quinine *** bitterness threshold of atomoxetine HCl was 8.61μg/ml based on the Change of membrane Potential caused by Adsorption(CPA)value of the BT0 *** this study,the taste-masking efficiency of 2-hydroxypropyl-β-cyclodextrin(HP-β-CyD)was assessed by Euclidean distances on a principle component analysis(PCA)map with the SA402B Taste Sensing System,and the host–guest interactions were investigated by differential scanning calorimetry(DSC),powder X-ray diffraction(XRD),nuclear magnetic resonance(NMR)spectroscopy and scanning electron microscopy(SEM).Biosensor evaluation and characterization of the inclusion complex indicated that atomoxetine HCl could actively react with 2-hydroxypropyl-β-cyclodextrin.

关键词： Atomoxetine HCl E-tongue Quantitative prediction host–guest interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synergistic modulation of spin and fluorescence signals in a nano-Saturn assembled by a metallofullerene and cycloparaphenylene nanohoop

引用

Nano Research 2023年第2期16卷 3372-3378页

作者： Jie Zhang Zhenlin Qiu Chong Zhao Yuxi Lu Wang Li Linshan Liu Chunru Wang Yuanzhi Tan Taishan Wang Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructure and NanotechnologyInstitute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materialsand Department of Chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China University of Chinese Academy of Sciences Beijing 100049China School of Pharmacy Guizhou Medical UniversityGuiyang 550025China

Spin-based interdisciplinary research has attracted considerable attention,and various applications in magnetic memory,quantum science,and precision measuring technology have been *** this study,we induced a fluorescence property in a spin-active molecule by supramolecular assembly and realized a synergistic modulation of its spin and fluorescence properties.A Saturn-shaped supramolecular complex was synthesized using a spin-active metallofullerene Sc_(3)C_(2)@C80 with a fluorescent nanohoop of tetra-benzothiadiazole-based[12]cycloparaphenylene(TB[12]CPP),and its spin and fluorescence properties were comprehensively ***-dependent electron paramagnetic resonance(EPR)spectroscopy and fluorescence analyses were *** changes in the EPR signals and fluorescence peaks were discovered in the temperature range of 170–290 *** on nuclear magnetic resonance observations and theoretical calculations,a temperature-dependent host–guest interaction between Sc_(3)C_(2)@C_(80)and a nanohoop was demonstrated,which explained the synchronous changes in the EPR signals and fluorescence peaks for Sc_(3)C_(2)@C_(80)⊂TB[12]*** application of Sc_(3)C_(2)@C_(80)as a molecular spin system to probe the host–guest interaction was also *** results show that the supramolecular assembly can be used to design advanced spin systems coupled with optical and magnetic behaviors based on paramagnetic and luminescent molecules.

关键词： metallofullerene nanohoop electron spin fluorescence host–guest interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Supramolecular Nanohelix Fabricated by Pillararene-Based host–guest System for Chirality Amplification, Transfer, and Circularly Polarized Luminescence in Water

引用

CCS Chemistry 2022年第10期4卷 3426-3439页

作者： Krishnasamy Velmurugan Adil Murtaza Azhar Saeed Jianing Li Kaiya Wang Minzan Zuo Qian Liu Xiao-Yu Hu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106 School of Physics MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed MatterXi’an Jiaotong UniversityXi’an 710049 State Key Laboratory for Mechanical Behaviour of Materials Shaanxi International Research Center for Soft MatterXi’an Jiaotong UniversityXi’an 710049

Amplified chirality and Förster resonance energy transfer(FRET)-assisted chirality transfer frommolecular to nanoscale level have been shown to play a vital role in co-assembled nanohelix for potential energy transfer in biological ***,we have constructed a chiral host–guest complex donor system for chiral amplification via induced chirality of pillar[5]arene host and loaded it with an achiral dye acceptor to demonstrate how chirality-assisted excitation energy transfer occurred in the supramolecular nanohelix system in an aqueous medium.

关键词： host–guest interaction supramolecular chirality chirality transfer circularly polarized luminescence supramolecular self-assembly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient Photocatalytic Reduction of CO_(2)Catalyzed by the Metal–Organic Framework MFM-300(Ga)

引用

CCS Chemistry 2022年第8期4卷 2560-2569页

作者： Tian Luo Zi Wang Xue Han Yinlin Chen Dinu Iuga Daniel Lee Bing An Shaojun Xu Xinchen Kang Floriana Tuna Eric JLMcInnes Lewis Hughes Ben FSpencer Martin Schröder Sihai Yang Department of Chemistry University of ManchesterManchester M139PL Photon Science Institute(PSI) University of ManchesterManchester M139PL Department of Physics University of WarwickCoventry CV47AL Department of Chemical Engineering and Analytical Science University of ManchesterManchester M139PL Institute of Chemistry Chinese Academy of ScienceBeijing 100190 Department of Earth and Environmental Sciences University of ManchesterManchester M139PL Department of Materials University of ManchesterManchester M139PL

Photocatalytic reduction of CO_(2)to carbon fuels is an important target but highly challenging to ***,we report the efficient photoconversion of CO_(2)into formic acid over a Ga(Ⅲ)-based metal–organic framework(MOF)material using triethanolamine as the sacrificial *** light irradiation and at room temperature,photoreduction of CO_(2) over MFM-300(Ga)yields formic acid with a selectivity of 100%.

关键词： MFM-300 metal–organic framework CO_(2)reduction photocatalysis host–guest interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：