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中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Wang Yi-jin ,He Shi-gang Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China

＜正＞Objective: To examine the development of axon terminals of horizontal cells in the mouse retina during early postnatal stage, and to find out the difference of this process between rd/rd mouse and wild

关键词： horizontal cells development retina mouse

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Modulation by Divalent Cations of GABAρ1 Receptor From Human Retina Expressed in Xenopus Oocytes

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Biomedical and Environmental Sciences 2001年第4期14卷 269-277页

作者： WANGQIN－WEN LIZHI－WANG 等 ResearchCenterofBasicMedicine WuhanInstituteofChildrenDIseaseWuhan430016China ResearchCenterofExperimentalMedicine TongjiMedicalUniversityWuhan430030China

Objective To investigate functional homooligomeric GABAρ1 receptors expressed in Xenopus oocytes and the modulation of divalent cations. Methods GABAρ1 cDNA from human retina was transcribed in vitro to obtain sense ρ1 mRNA, which was microinjected into Xenopus oocytes. Two-electrodes voltage clamp technique was performed to record GABA-induced currents. Results Expressed receptors were found to have similar properties to GABA C receptors characterized in the retina. Cl-currents induced by GABA were blocked by picrotoxin instead of bicuculline. GABA-induced currents reversed at -19±2.5 mV, and EC 50 was 3.3 μmol/L. Zn ++ modulated GABA-induced currents with an IC 50=9.6 μ mol/L. Ni ++, Cu ++ and Cd ++ inhibited GABA ρ1 obviously, too. Their rank order of potency was Zn ++>Ni ++>Cu ++>Cd ++. Conclusion Zinc(10 μmol/L) inhibited GABA-induced currents in a competitive manner, and its action was sensitive to extracellular pH. Site-directed mutagenesis revealed that substitution of a single histidine residue (H44 and H48) failed to affect zinc sensitivity.

关键词： AMINOBUTYRIC-ACID RECEPTORS horizontal cells C-RECEPTOR ZINC PHARMACOLOGY CHANNELS RESPONSES PROTEINS ENZYMES NEURONS

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Impacts of the retinal environment and photoreceptor type on functional regeneration

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Neural Regeneration Research 2017年第3期12卷 376-379页

作者： Michèle G.Du Val W.Ted Allison Department of Biological Sciences University of Alberta Department of Medical Genetics University of Alberta

Retinal regeneration is a promising central nervous system（CNS） target amongst the various stem cell therapy pursuits,due to its accessibility for manipulation and its disposition towards longitudinal monitoring of treatment safety and *** offer our perspective on current hurdles towards functional regeneration of cone *** are key：For patients suffering vision loss,cone photoreceptors are a required cellular component to restoring daytime vision,colour vision,and high acuity *** challenges of regenerating cones contrast with logistic challenges of regenerating rod photoreceptors,which underlines the importance of evaluating context in degeneration and regeneration *** research is required to delineate the factors required to generate a diversity of cones in the human macula,and to coax both remaining and newly regenerating cones to rewire towards restoring daytime colour vision.A complex interplay between cell-intrinsic factors and the retinal environment determine both the specification of cone fates and the synaptic plasticity enabling their functional *** revelations that cellular materials are transferred amongst photoreceptor progenitors further emphasize the critical role of neighbouring cells in directing stem cell *** our vantage point,translation of stem cell therapies to restore the cone-rich human macula must be borne upon foundational research in cone-rich *** frameworks centered on patient outcomes should prioritize animal models and functional outputs that enable and report functional restoration of cone-mediated vision.

关键词： zebrafish synaptic plasticity horizontal cells material transfer vision neural development

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