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Smart homing guidance strategy with control saturation against a cooperative target-defender team

Journal of Systems Engineering and Electronics 2019年第2期30卷 366-383页

作者： GUO Hang FU Wenxing FU Bin CHEN Kang YAN Jie School of Astronautics Northwestern Polytechnical University

A smart homing guidance strategy with control saturation against a target-defender team is derived. It is noteworthy that a cooperative strategy of the target-defender team is applied,which has been proved more challenging for the homing *** defender missile is launched by the target and guided by a cooperative augmented proportional navigation(APN). At the same time, the target performs a one-switch maneuver to cooperate and minimize the defender's acceleration requirement. The problem is analyzed for arbitrary-order linear dynamics of the agents in the linearized form but validated by the mathematical simulations by using nonlinear kinematics. The perfect information of three agents' states is assumed. Then, a method to deal with the target-defender team is proposed. It contains a combined performance index penalizing the miss distance relative to the target and energy consumption in the whole duration. Besides, the specific miss distance related to the defender is regarded as an inequality constraint. An analytical solution for the smart guidance strategy against the APN guided defender is derived. Meanwhile, the control saturations are introduced to get more realistic and reasonable insights to this practical target-missile-defender problem. A simple but effective iterative searching technique is proposed to determine the saturation time points. The solution provides an optimal homing strategy to evade the defender with a specific miss distance and intercept the target with the minimum miss distance in the minimum energy manner. Nonlinear two-dimensional simulation results are used to validate the theoretical analysis. By comparison with the optimal differential game guidance(ODGG) and the combined minimum effort guidance(CMEG), the superiority of this smart guidance strategy is concluded.

关键词： smart homing guidance control saturation targetmissile-defender iterative searching technique

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homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?

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World Journal of Stem Cells 2016年第3期8卷 73-87页

作者： Ann De Becker Ivan Van Riet Department Clinical HematologyStem Cell Laboratory Universitair Ziekenhuis Brussel Vrije Universiteit Brussel (VUB)

Mesenchymal stromal cells(MSCs) are currently being investigated for use in a wide variety of clinical applications. For most of these applications, systemic delivery of the cells is preferred. However, this requires the homing and migration of MSCs to a target tissue. Although MSC hominghas been described, this process does not appear to be highly efficacious because only a few cells reach the target tissue and remain there after systemic administration. This has been ascribed to low expression levels of homing molecules, the loss of expression of such molecules during expansion, and the heterogeneity of MSCs in cultures and MSC culture protocols. To overcome these limitations, different methods to improve the homing capacity of MSCs have been examined. Here, we review the current understanding of MSC homing, with a particular focus on homing to bone marrow. In addition, we summarize the strategies that have been developed to improve this process. A better understanding of MSC biology, MSC migration and homing mechanisms will allow us to prepare MSCs with optimal homing capacities. The efficacy of therapeutic applications is dependent on efficient delivery of the cells and can, therefore, only benefit from better insights into the homing mechanisms.

关键词： Mesenchymal stromal cells homing Bone marrow homing receptors Extravasation

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Design and simulation for large parafoil fix line object homing algorithm

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Journal of Central South University 2016年第9期23卷 2276-2283页

作者： LI Chun Beijing Institute of Space Machine and Electricity Beijing 100076 China School of Instrument Science and Engineering Southeast University Nanjing 210096 China

Traditional parafoil homing usually uses a point as object. As the mobility of parafoil is limited by its glide ratio and wind, in some cases when the parafoil scatter area is large, or the glide ratio of parafoil is small, the deviation of its landing point to object point will be arduous to control. Accordingly, during these situations, when parafoil is used in recovery of spacecraft or satellite, the landing area of parafoil can be set as a rectangle, and the object of parafoil can be set as a line segment. The thesis of this work is designing an algorithm for parafoil homing using line segment as object. The algorithm of wind velocity and direction calculation in different flying segments was also investigated. The algorithm designed navigates the parafoil to land into the predestined area and largely reduce the probability of recovery loads falling to unwanted area to damage houses and people.

关键词： fix line homing parafoil algorithm design simulation

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Postsynaptic Potentials and Morphological Features of Tectal Cells in homing Pigeons

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Science China Chemistry 1993年第3期36卷 297-304页

作者：吴冈义王书荣颜坤 Laboratory for Visual Information Processing Institute of Biophysics Academia Sinica Beijing 100101 PRC

In this study postsynaptic potentials responding to the electrical stimulation of the optic nerve and the nucleus isthmipars parvocellularis (Ipc) were intracellularly recorded from 86 tectal cells in pigeons, 13 of which were marked with Lucifer yellow (LY). According to types of postsynaptic potentials and their succesion, the postsynaptic responses could be classified into four types: excitatory postsynaptic potential (EPSP)-inhibitory postsynaptic potential (IPSP) sequence (EI type), E, I and IE *** them, E or EI responses were mainly produced to the optic nerve stimulation, while the electrical stimulation of the lpc elicited I responses in more than half the recorded ***-marked tectal cells included five ganglionic cells, four pyramidal cells, two bipolar cells and two stellate *** ganglionic cells were mainly located in tectal layers Ⅲ and Ⅳ, whereas the others were in layer Ⅱ.It appears from both intracellular recordings and fluorescent markings that there is some correlation betwe n the morphological features and the postsynaptic response types of tectal cells.

关键词： homing pigeon nucleus isthmi tectum postsynaptie potentials electrical stimulation fluorescent marking.

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Endothelial Progenitor Cells homing to the Orthotopic Implanted Liver Tumor of Nude Mice

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第5期32卷 675-679页

作者：朱智陈刚李兴睿殷茜杨志芳易继林 Department of Breast and Thyroid Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Hepatobiliary Surgery the First Affiliated HospitalWenzhou Medical College

This study investigated the 'homing' phenomenon in hepatocellular carcinoma (HCC).The 'homing' specificity of endothelial progenitor cells (EPC) by establishing an orthotopic implantation model in nude *** harvested from the marrow cells were separated by density gradient *** microscope,flow cytometry (FCM) and double fluorescence staining with FITC-UEA-I and DiI-ac-LDL,were employed to identify the cells.4',6-diamidino-2-phenylindole (DAPI) labelling and real-time PCR were used for detecting the expression of CD133 and chemokines to trace and observe the distribution of *** results showed that the distribution rate of EPCs was obviously higher than that in other important organs and the negative control *** of CD133 and chemokines yielded similar results in difference *** experiment confirmed that the chemotaxis of EPCs does exist in ***,HIF-1α,SDF-1 and VEGF might play important roles in the 'homing' of EPCs in *** might be a potential candidate for targeting vector of HCC for gene therapy.

关键词： EPCs hepatocellular carcinoma homing targeted therapy gene therapy

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Stem cell homing, tracking and therapeutic efficiency evaluation for stroke treatment using nanoparticles: A systematic review

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World Journal of Stem Cells 2020年第5期12卷 381-405页

作者： Mariana Penteado Nucci Igor Salerno Filgueiras Joao Matias Ferreira Fernando Anselmo de Oliveira Leopoldo Penteado Nucci Javier Bustamante Mamani Gabriel Nery Albuquerque Rego Lionel Fernel Gamarra LIM44 Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 05529-060Brazil Hospital Israelita Albert Einstein Sao Paulo 05529-060Brazil Centro Universitário do Planalto Central BrasíliaDFBrazil

BACKGROUND Stroke is the second leading cause of death *** is a real need to develop treatment strategies for reducing neurological deficits in stroke survivors,and stem cell(SC)therapeutics appear to be a promising alternative for stroke therapy that can be used in combination with approved thrombolytic or thrombectomy ***,the efficacy of SC therapy depends on the SC homing ability and engraftment into the injury site over a long period of ***,tracking SCs from their niche to the target tissues is a complex *** To evaluate SC migration homing,tracking and therapeutic efficacy in the treatment of stroke using nanoparticles METHODS A systematic literature search was performed to identify articles published prior to November 2019 that were indexed in PubMed and *** following inclusion criteria were used:(1)Studies that used in vivo models of stroke or ischemic brain lesions;(2)Studies of SCs labeled with some type of contrast agent for cell migration detection;and(3)Studies that involved in vivo cellular homing and tracking *** A total of 82 articles were identified by indexing in Scopus and Pub *** inclusion criteria were applied,35 studies were selected,and the articles were assessed for eligibility;ultimately,only 25 studies were *** of the selected studies used SCs from human and mouse bone marrow labeled with magnetic nanoparticles alone or combined with fluorophore *** cells were administered in the stroke model(to treat middle cerebral artery occlusion in 74%of studies and for photothrombotic induction in 26%of studies).Fiftythree percent of studies used xenogeneic grafts for cell therapy,and the migration homing and tracking evaluation was performed by magnetic resonance imaging as well as other techniques,such as near-infrared fluorescence imaging(12%)or bioluminescence assays(12%).CONCLUSION Our systematic review provided an up-to-date evaluation of SC migration hom

关键词： Stem cell Nanoparticles homing Tracking Near-infrared fluorescence image Cellular therapy Magnetic resonance image Bioluminescence Stroke

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Effects of Panax Notoginseng Saponins on homing of C-kit^+ Bone Mesenchymal Stem Cells to the Infarction Heart in Rats

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Journal of Traditional Chinese Medicine 2011年第3期31卷 203-208页

作者：张金生何庆勇黄涛张宝霞 First Affiliated Hospital of Henan Traditional Chinese Medicine College Guang'anmen Hospital China Academy of Chinese Medical Sciences Huanghe Science and Technology College

Objective:To investigate the effects of panax notoginseng saponins(PNS) on homing of C-kit+ bone mesenchymal stem cells(BMSCs) to the infarction ***:The acute myocardial infraction(AMI) model was established in 140 Wistar rats,105 model rats survived after operation,and the model rats were randomly divided into five groups,21 rats in each group:Western medicine group mobilized by subcutaneous injection of human granuloctye colony stimulating factor(G-CSF) 50 μg·kg-1·d-1;sham operation group and a model group treated by subcutaneous injection of normal saline 50 μg·kg-1·d-1;Chinese medicine group mobilized by intraperitoneal injection of Xuesaitong(血塞通)(ingredients of PNS) 150 mg·kg-1·d-1;integrative medicine group mobilized by subcutaneous injection of G-CSF 50 μg·kg-1·d-1 and intraperitoneal injection of Xuesaitong 150 mg·kg-1·*** for the sham-operated group,each group was divided into three sub-groups by three time points of 1 d,7 d and 14 d.G-CSF was injected once a day for 7 *** was injected once a day until the rats were *** flow cytometry was used for detection of C-kit + cells in the peripheral blood in different time points,and immunohistochemical method was used for detection of the changes of C-kit + cell and Ki-67+ cell numbers in the marginal zone of ***:Twenty-four hours after the operation,C-kit + cells had a slight increase in the model group compared with the sham operation group(P>0.05).The peripheral blood C-kit+ cells in the integrative group increased significantly compared with the other groups on 7 d and 14 d(all P<0.05).Meanwhile the expression of C-kit + cells and Ki-67+ cells in the marginal zone of AMI in the integrative group increased significantly compared with the Chinese medicine group,the western medicine group and the model group on 1 d,7 d and 14 d(all P<0.05),and the cells in the integrative group decreased significantly on 14 d compared with that on 7 d(P<0.05).Conclusion:PNS can cooperate

关键词： Panax notoginseng saponins(PNS) bone mesenchymal stem cells (BMSCs) homing experimental research

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Effect of HuoguⅡFormula(活骨Ⅱ方) with Medicinal Guide Radix Achyranthis Bidentatae on Bone Marrow Stem Cells Directional homing to Necrosis Area after Osteonecrosis of the Femoral Head in Rabbit

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Chinese Journal of Integrative Medicine 2012年第10期18卷 761-768页

作者：孔祥英王荣田田能李莉林娜陈卫衡 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Wangjing Hospital China Academy of Chinese Medical Sciences

Objective： To investigate the effect of Huogu II Formula （活骨 II方） with medicinal guide Radix Achyranthis Bidentatae （Ach） on bone marrow stem cells （BMSCs） homing to necrosis area after osteonecrosis of the femoral head （ONFH） frozen by liquid nitrogen in rabbit as well as to explore the mechanism of prevention and treatment for ONFH. Methods： The animal model of ONFH was established by liquid nitrogen frozen on the rabbit left hind leg. Forty-eight Japanese White rabbits were randomly assigned to sham-operated group, model group, Huogu II group, and Huogu II plus Ach group, with 12 rabbits in each. During the course of ONFH animal model establishment, all rabbits were subcutaneously injected with recombinant human granulocyte colony-stimulating factor [rhG-CSF, 30 μg/（***） for continuous 7 days]. Meanwhile, normal saline and decoction of the two formulae were administrated by gavage, respectively. White blood cells （WBC） were counted in peripheral blood before and after injection of rhG-CSF. Materials were drawn on the 2rid and 4th weeks after model built; bone glutamine protein （BGP） and bone morphogenetic protein 2 （BMP2） levels in serum were tested. Histopathologic changes were observed by hematoxylin and eosin （HE） staining. BMP2 mRNA levels were detected with in situ hybridization （iSH） staining. 5-Bromo-2＇-deoxyuridine （BrdU） and stromal cell derived factor 1 （SDF-1） were measured by immunohistochemical assay in femoral head of the left hind leg. Results： Compared with the shamoperated group, the ratio of empty lacuna, serum BGP, and SDF-1 level in the model group increased significantly, and BMP2 in both serum and femoral head decreased significantly. However, in comparison with the model group, the empty lacuna ratio of Huogu II group and Huogu II plus Ach group decreased obviously in addition to the levels of serum BGP and BMP2, and the expressions of BMP2 mRNA, BrdU, and SDF-1 increased significantly. Above changes were particularly obvious in Huogu I

关键词： osteonecrosis of the femoral head bone marrow stem cells homing guide drug to affected area

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Induced Monocytes-Derived HSCs (CD34+) with LPS Accelerated homing Rat Bone Marrow-Mesenchymal Stem Cell (BM-MSCs, CD105) in Injured Pancreas

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Journal of Biomedical Science and Engineering 2015年第5期8卷 333-344页

作者： Fedik A. Rantam Purwati Budi Setiawan Sony Wibisono Ferdiansyah Joni Wahyuhadi Edward Mouli Dwikora N. Utomo Heri Suroto Candra Bumi Stem Cell Laboratory Institute of Tropical Disease Airlangga University Surabaya Indonesia Virology and Immunology Laboratory Department of Microbiology Faculty of Veterinary Medicine Airlangga University Surabaya Indonesia Tropic and Infection Division of Internal Medicine School of Medicine Airlangga University Surabaya Indonesia Animal Surgery Animal Hospital Faculty of Veterinary Medicine Airlangga University Surabaya Indonesia Regenerative Medicine Department of Orthopedic Dr. Soetomo Teaching Hospital/School of Medicine Airlangga University Surabaya Indonesia Department of Neurosurgery Dr. Soetomo Teaching Hospital/School of Medicine Airlangga University Surabaya Indonesia

Investigating the function of combining induced rat monocytes-derived bone marrow-haemopoietic stem cell (rat BM-HSCs) with LPS and rat bone marrow-mesenchymal stem cell (rat BM-MSCs) was to analyze the acceleration of homing process mechanism in injured pancreas. Mononucleated stem cells were isolated from aspirated whole rat BM using ficoll and cultured in α-MEM complete growth medium in 10 cm petridish. After two days, adherent cells after washing twice in petridish were added α-MEM growth medium and then mesenchymal cells were characterized using CD105 marker in third passage and labeled PKH26. Then haemopoietic stem cells (HSCs) were isolated with magnetic beads CD34+ and differentiated in vitro, and then induced monocytes with LPS. Animal experiment used 28 male Wistar rats, and divided them into 4 groups. After transplantation combined, both cells between monocyte derived HSc (mHSCs) and rat BM-MSC were analyzed expression of pair box gen 4 (Pax4), pancreatic and duodenal homeobox (Pdx1), C-peptide using immunohistochemistry, then secretion of insulin and C-peptide analyzed using indirect ELISA. Results showed that the expressions of Pax4, Pdx1, C-peptide found in the surface membrane cell of pancreatic cell, and secreted C-peptide and insulin were shown significant (P homing MSCs into injured pancreatic tissue.

关键词： Induced Monocyte Derived HSCs Rat BM-MSCs homing Injured Pancreas

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双归属（dual　homing）

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电信科学 1996年第7期 61-62页

作者：雷震洲邮电部科学技术情报研究所

双归属（ｄｕａｌｈｏｍｉｎｇ）雷震洲（邮电部科学技术情报研究所北京１０００８３）通信公司为了向用户提供足够高的服务能力（ｓｅｒｖｉｃｅａｂｉｌｉｔｙ），也就是使用户对所提供的服务有很高的满意度（ｃｕｓｔｏｍｅｒｓａｔ... 详细信息

双归属（ｄｕａｌｈｏｍｉｎｇ）雷震洲（邮电部科学技术情报研究所北京１０００８３）通信公司为了向用户提供足够高的服务能力（ｓｅｒｖｉｃｅａｂｉｌｉｔｙ），也就是使用户对所提供的服务有很高的满意度（ｃｕｓｔｏｍｅｒｓａｔｉｓｆａｃｔｉｏｎ），必须在一开始...

关键词：双归属端局 homing dual 枢纽中心

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