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Loss of cell adhesion molecule CHL1 improves homeostatic adaptation and survival in hypoxic stress

Loss of cell adhesion molecule CHL1 improves homeostatic ada...

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中国神经科学学会第十届全国学术会议

作者： Xin HUANG Jia SUN Weifang RONG Tong ZHAO Li-ying WU Kuiwu WU Melitta SCHACHNER Zhi-Cheng XIAO Ling-ling ZHU Ming FAN Institute of Molecular and Clinical Medicine Kunming Medical College

Objective CHLl is a transmembrane cell adhesion molecule that is critical for brain development and in the maintenance of neural circuits in the adult.Recent studies revealed that CHLl has diverse roles and is involved in the regulation of recovery after spinal cord injury.CHLl expression was down-regulated in the cerebral cortex,hypothalamus and brain stem after induction of acute hypoxia.In the current study we sought to address the role of CHLl in regulating homeostasis responses to hypoxia using CHLl knockout(CHLl) mice.Results We found that,compared with the wild type littermates,CHLl mice showed a dramatically lower mortality rate and an augmented ventilatory response after they were subjected to acute hypoxia.Immunofluorescence staining revealed that CHLl was expressed in the carotid body(CB),the key oxygen sensor in rodents and CHLl expression level in CB as assayed by western blot was decreased after hypoxic exposure.The number of glomus cells and the expression of tyrosine hydroxylase(TH,a marker for glomus cells) in CB of CHLl mice appeared to be increased compared with CHL1mice.In addition,in the ex vivo carotid body preparation,hypoxia induced a significantly greater afferent nerve discharge in CHLl mice compared with the CHL1 mice.Furthermore,the arterial blood pressure and plasma catecholamine level of CHLl mice were also significantly higher than those of CHL1 mice.Conclusion Our findings first demonstrate that CHLl is a novel intrinsic factor that is involved in carotid body function and in the ventilatory response to acute hypoxia.

关键词： CHL1 acute hypoxia homeostatic adaptation survival

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Loss of cell adhesion molecule CHL1 improves homeostatic adaptation and survival in hypoxic stress

Loss of cell adhesion molecule CHL1 improves homeostatic ada...

引用

中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：黄欣 Weifang Rong Tong Zhao Liying Wu lingling Zhu Ming Fan 军事医学科学院基础医学研究所军事认知研究室

Objective CHL1 is a transmembrane cell adhesion molecule that is critical for brain development and in the maintenance of neural circuits in the adult.Recent studies revealed that CHL1 has diverse roles and is involved in the regulation of recovery after spinal cord injury.CHL1 expression was down-regulated in the cerebral cortex,hypothalamus and brain stem after induction of acute hypoxia.In the current study we sought to address the role of CHL1 in regulating homeostasis responses to hypoxia using CHL1 knockout（CHL1-/-）mice.Results We found that,compared with the wild type littermates,CHL1-/-mice showed a dramatically lower mortality rate and an augmented ventilatory response after they were subjected to acute hypoxia.Immunofluorescence staining revealed that CHL1 was expressed in the carotid body（CB）,the key oxygen sensor in rodents and CHL1 expression level in CB as assayed by western blot was decreased after hypoxic exposure.The number of glomus cells and the expression of tyrosine hydroxylase（TH,a marker for glomus cells）in CB of CHL1-/-mice appeared to be increased compared with CHL1+/+mice.In addition,in the ex vivo carotid body preparation,hypoxia induced a significantly greater afferent nerve discharge in CHL1-/-mice compared with the CHL1+/+mice.Furthermore,the arterial blood pressure and plasma catecholamine level of CHL1-/-mice were also significantly higher than those of CHL1+/+mice.Conclusion Our findings first demonstrate that CHL1 is a novel intrinsic factor that is involved in carotid body function and in the ventilatory response to acute hypoxia.

关键词： CHL1 acute hypoxia homeostatic adaptation survival

来源： cnki会议评论

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