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Invasive Infections for Endemic Fungi in Pediatrics in Guatemala

World Journal of AIDS 2018年第3期8卷 63-75页

作者： Julio Werner Juárez Lorenzana María Luisa Navarro Gómez Andrea Palma Comprehensive Care Unit of HIV and Chronic Infections “Dr. Carlos Rodolfo Mejia” Roosevelt Hospital Guatemala City Guatemala Infectious Diseases Section Pediatrics Service School of Medicine Complutense University of Madrid University General Universitario Gregorio Mara&ntilde ón Madrid Spain General Physician Rafael Landívar University Guatemala City Guatemala

Background: Invasive fungal infections are common opportunistic diseases in patients with AIDS, other conditions related to immunodeficiency and healthy infants. Most publications on this subject are related to industrialized countries, and in adult population, with limited data in Latin America (except for Brazil, Colombia, and Argentina), and especially in pediatric population. These patients present a variety of clinical manifestations representing a diagnostic and therapeutic challenge for the health system. Objective: The objective of the study is to describe the epidemiological and laboratory characteristics of children with invasive fungal infections in Guatemala. Methods: A review of the microbiology service database was carried out at Roosevelt Hospital in Guatemala. Positive cultures were taken from children under 15 years of age, in a period of seven years, from 2007 to 2014, with its corresponding medical history. Results: Finally, 23 isolates were documented but only 15 patients were included in the study with complete information;10 Histoplasma capsulatum cases, 4 Cryptococcus neoformans cases and 1 Coccidioidessp case. The average age was 7 years old for Histoplasma and 9 years old for Criptococo, with an age range from 6 months to 14 years. Around 60% of the patients were older than 5 years, of which, more than two-thirds were HIV positive children without antiretroviral therapy, who presented an invasive fungal infection at the time of HIV diagnosis. These infections are endemic in Guatemala, so the distribution was mostly uniform. Around 80% of the patients had some disease related to immunodeficiency and 70% were infected with human immunodeficiency virus (HIV). The microbiological isolation was from blood, bone marrow, lymph nodes, cerebrospinal fluid and urine. The predominant laboratory findings were decrease in hematological series. The most frequent clinical syndromes were fever, adenomegaly, hepatosplenomegaly, respiratory, gastrointestinal,

关键词： Cryptococcosis histoplasmosis Coccidioidomycosis Invasive Infection Pediatrics Immunodeficiency HIV (Human Immunodeficiency Virus)

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