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Pathological Study of Noncirrhotic Hepatocellular Carcinoma:Its Etiology and histogenesis

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Journal of Medical Colleges of PLA 1986年第4期 348-355页

作者：陶文照吴存忠王建军王能进邵龙琪曾庆镒彭宝珍吴高德 Department of Patho-anatomy Second Military Medical College.Shanghai

This work was undertaken to investigate the etiology and histo-genesis of non-cirrhotic hepatocellular car-cinoma(NCH)in *** the 142 cases of NCH studied,135 were samplesobtained from surgical resection and 7 from *** speci-mens from cirrhotic hepatocellular carcinoma(CH)were taken ascontrol(42 from operated material and 8 from autoptic material.,The results were as follows:*** B liver diseases and Orcein negative hepatitis liverdiseases accounted for 51.41% and 48.59% in NCH group,and 58.00%and 42.00% in CH group,suggesting that the two groups had asimilar background of liver *** proliferation of oval cells was found to be 80.99% inNCH group and 100% in CH group(the difference was statisticallysignificant).It is suggested that oval cells exposed to carcinogensmight develop into poorly differentiated and adenoid type of *** dysplasia was found to be 29.57% and 70.00%in NCH and CH group respectively,and there was a significantdifference between the two groups of *** believe that dys-plasia may be a precancerous disorder.

关键词： etiology histogenesis tumor,noncirrhotic hepatocellular carcinoma

A study of histogenesis of pulmonary sclerosing hemangioma

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The Chinese-German Journal of Clinical Oncology 2007年第6期6卷 528-532页

作者： Xiao Zhou Xianghua Yi Meifang Zhu Chest Surgery Shanghai Pulmonary Hospital Tongji University Shanghai 200433 China Department of Pathology Shanghai Pulmonary Hospital Tongji University Shanghai 200433 China

Objective： To investigate the histogenesis and differential diagnosis of pulmonary sclerosing hemangioma （PSH）. Methods： Thyroid transcription factor-1 （TTF-1）, surfactant proteins A, B （SP-A, SP-B）, epithelial membrane antigen （EMA）, vimentin, pancytokeratin, cytokeratin7 （CK7）, CK5/6, calretinin, S-100, neurospecific enolase （NSE）, synaptophysin （Syn）, chromogranin A （CgA）, CD34, factor-Ⅷ-related antigen （F-Ⅷ） and smooth muscle actin （SMA）in 55 patients with PSH were examined with immunohistochemistry, while samples from 19 patients were also observed by electron microscope. Follow-up information were reviewed. Results： Pathologically, PSH mainly consisted of both surface lining cuboidal cells and pale polygonal cells. Immunohistochemitry revealed that coexpression of TTF-1, EMA and vimentin in both cuboidal and polygonal cells was 94.5 % （52/55）, 90.5% （50/55） and 58.2% （32/55）, respectively. In cuboidal cells, the expression of SP-A and SP-B was 92.7% （51/55） and 81.8 % （45/55）, respectively. Whereas pancytokeratin and CK7 immunostained the cuboidal cells in all cases. The polygonal cells were difussed immunostained with Syn in 13 PSHs （24%） and NSE in 8 PSHs （15%）, while immunoreactions with S-100 and CgA were separated detected in 7 PSHs （13%）. There was no significant difference of TTF-1 and EMA expression between these two cells （χ^2 value was 1.371 and 3.352, respectively. P 〉 0.05）. In contrast, there was a significant difference of vimentin between them （χ^2 value was 17.720, P 〈 0.001）. Electron microcopy observation showed that ultrastructure may not differ from each other sometime. The follow-up was obtained for 49 cases ranged from 3 months to 14 years. 48 of them had no recurrence or metastasis except one case had recurrence. Conclusion： PSH may origin from the primitive respiratory epithelial. Polygonal and cuboidal cells are all parenchymal neoplasm cells. The concomitant examination of TTF-1, SPA, SP-B, EMA, virnentin and pancytokeratin may favor

关键词： sclerosing hemangioma, lung thyroids transcription factor surfactant protein histogenesis diagnosis differential

Granular cell tumor of the cecum with extensive hyalinization and calcification:A case report

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World Journal of Gastroenterology 2009年第26期15卷 3315-3318页

作者： Ran Hong Sung-Chul Lim Department of Pathology Chosun University School of Medicine Gwangju 501-140 South Korea Research Center for Resistant tells Chosun University School of Medicine Gwangju 501-140 South Korea

A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath *** is not common and most often affects the tongue,skin and soft tissue,although it may occur anywhere in the *** experienced a case of GCT that arose in the cecum of a 55-yearold *** GCT was removed by laparoscopic *** addition to the tumor,endoscopic examination revealed the presence of a 5-mm-polyp in the descending colon and multiple tiny polyps in the sigmoid colon and *** examination demonstrated a cecal tumor 1.5 cm × 1.0 cm × 0.7 cm with a hard consistency;in cut sections,mixed cells with yellowish and whitish portions were *** tumor was located between the mucosa and subserosa,and was composed of plump histiocyte-like tumor cells with abundant granular eosinophilic cytoplasm,which were immunoreactive for S-100 protein,vimentin,neuron-specific enolase,inhibin-α and *** tumor showed extensive hyalinization and focal dystrophic *** profiles did not confirm any particular cell type for the histogenetic origin of the GCT,including a nerve sheath *** hyalinization and calcifi cation showing involution of tumor cells suggest benign clinical behavior of GCT.

关键词： Granular cell tumor Cecum histogenesis Calcification

Histopathological and genetic differences between polypoid and non-polypoid submucosal colorectal carcinoma

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World Journal of Gastroenterology 2007年第14期13卷 2048-2052页

作者： Ichiro Hirata Fang-Yu Wang Mitsuyuki Murano Takuya Inoue Ken Toshina Takashi Nishikawa Kentaro Maemura Department of Gastroenterology Fujita Health University Japan Department of Gastroenterology Jinling Hospital Nanjing University School of Medicine Nanjing 210000 Jiangshu Province China Second Department of Internal medicine Osaka medical College Japan Department of Anatomy Osaka Medical College Japan

AIM： To investigate the histopathological and geneticdifferences between polypoid growth （PG） and nonpolypoid growth （NPG） submucosal invasive colorectal carcinoma （CRC）.METHODS： A total of 96 cases of submucosal CRC were divided into two groups according to their growth type;60 cases of PG and 36 cases of NPG. The size, histological degree of dysplasia, depth of submucosal invasion and lymph node metastasis were compared between the two groups. Furthermore, expression of p53 was detected by immunohistochemical staining, and K-ras gene mutation was examined by polymerase chain reaction based single-strand conformation polymorphism （SSCP）.RESULTS： The average size of the lesions in the NPG group was significantly smaller than those in the PG group （7.5 mm vs 13.8 mm, P 〈 0.001）. The histological degree of dysplasia tended to be more severe in NPG group, while the incidence of submucosal massive invasion and the lymph node metastasis were both significantly higher in the NPG type than in the PG group （64.3% vs 43.3%, P = 0.004; 43% vs 7%, P =0.008, respectively）. In addition, K-ras gene mutations were detected in 67% of lesions in the PG group, but none in the NPG group, while no difference in p53immunohistochemical expression was found between the two groups.CONCLUSION： Compared with PG submucosal CRC,NPG type demonstrates more frequent submucosal massive invasion, more lymph node metastasis and a higher degree dysplasia. Genetically, NPG type shows much less frequent K-ras mutation.

关键词： Colorectal cancer Early/submucosal Polypoidgrowth Non-polypoid growth histogenesis K-ras gene p53

Effects of Ligustrazine on Hematopoiesis in the Early Phase of Bone Marrow Trans plantation Mice

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第3期22卷 200-202页

作者：周银莉刘文励孙汉英徐惠珍路武孙岚孟凡凯 Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030

To investigate the effects of Ligustrazine on histogenesis of bone marrow in the early phase of hematopoietic reconstruction in bone marrow transplantation (BMT ) mice. The syngeneic BMT mice model was established. The syngeneic BMT mice were orally given 2 mg Ligustrazine twice a day. 1, 3, 5, 7, 10, 15 and 21 day(s) after BMT, peripheral blood granulocytes and bone marrow nucleated cells (BMNC) were counted and the diameter of central vein and the area of micro vessel in femur were measured. The effect of Ligustrazine on hematopoietic stem cells was observed by colony forming unit of spleen (CFU S). The effect of Ligustrazine on hemopoietic progenitors was studied by observing the number of progenitors of Granulocytes/Macrophage on day 10 and day 20 after BMT. In Ligustrazine treated group, the diameter of center veins and the area of micro vessel of femur were all significantly less than the control group 7, 10, 15, 21 days after BMT ( P histogenesis of hemopoietic bone marrow, which may be one mechanism by which Ligustrazine promotes hematopoietic reconstitution after BMT.

关键词： bone marrow transplantation hematopoietic reconstitution histogenesis hexagon al sinus Ligustrazine

Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report

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Chinese Medical Sciences Journal 2023年第2期38卷 138-146页

作者： Fatemeh Mashhadiabbas Sanaz GholamiToghchi Roohollah Safarpour Department of Oral and Maxillofacial Pathology School of DentistryShahid Beheshti University of Medical SciencesTehran ***Iran Department of Oral and Maxillofacial Pathology School of DentistryLorestan University of Medical SciencesKhorramabad ***Iran

Central granular cell odontogenic tumors(CGCOTs)are rare,benign,slowly growing odontogenic *** to their uncertain histogenesis,CGCOTs are still not included as a distinct entity in the WHO classification(2017)of odontogenic *** report a case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white *** staining showed that granular cells positively expressed CD68 and vimentin,and negatively expressed S-100 ***,we searched Pub Med,Google Scholar,and Scopus databases to summary the clinico-pathological features of 51 reported cases of *** results showed that the granular cells of 28.6%cases were immunopositive for vimentin and CD68,and odontogenic epithelial cells were positive immunoreactivity for *** findings reinforced the mesenchymal origin of granular cells and the odontogenic nature of epithelium islands.

关键词： central granular cell odontogenic tumor central granular cell odontogenic fibroma odontogenic tumor granular cell ameloblastic fibroma histogenesis

Treatment of forearm diaphyseal defect by distraction compression bone transport and continued distraction for radial head reduction:A case study

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Chinese Journal of Traumatology 2019年第5期22卷 304-307页

作者： Nikolay M.Kliushin Paul Stepanenko Waleed A.Mekki Bone Infection Clinic Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics6M.Ulianovast.Kurgan 640014Russian Federation

Treatment of infected forearm nonunion and defects represents a difficult task for the operating *** methods like composite and vascularized fibular grafts and the induced membranes filled with cancellous autografts or the Masquelet technique have been reported to be useful and suc-cessful,but sometimes it is difficult to predict the outcome and cannot address simultaneous deformities or the need to apply gradual distraction for reduction of a chronically dislocated radial *** technique has an answer for such *** report a 43 years old man with infected ulnar defect and dislocated radial head as a result of infected Monteggia fracture:the patient was successfully treated by Ilizarov bone transport after failed attempts by bone spacer and fibular graft.

关键词： Monteggia's fracture Forearm defects Ilizarov technique Distraction histogenesis Bone transport

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蒙古绵羊胚胎肾脏的组织学发生

蒙古绵羊胚胎肾脏的组织学发生

作者：刘增力内蒙古农业大学

学位级别：硕士

This report had researched the Histognesis of kidney embryo of sheep stem length from 15mm-510mm length. Under convention slice technique of tissue selection and electron microscope. This result showed that the 15mm body already generated fundament of it's embryo definiye kidney. But without IV stage acinus renails emerged until 37mm length. Ray medullary occurred at 85mm length embryo of kidney. Proximal convoluted tubule. Distal convoluted tubule occred at 65mm length embryo of kidney. Cortex at Kidney 135mm length embryo, medullary distinguished obviously, and border gone occurred. At the time from 25mm-400mm length, under the subsfance caps, acinus renails have been always *** stopped till 510mm length. Macula densa had created in distal convoluted tubule at 85mm length. Consummate filtration barrier had emerged at least before 55mm length embryo about kidney.

关键词： Mongolia sheep Embryo Kidney histogenesis