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Aneurysmal Fibrous histiocytoma:Clinicopathology Analysis of 30 Cases of a Rare Variant of Cutaneous Fibrohistiocytoma

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Current Medical Science 2019年第1期39卷 134-137页

作者： Amelia Nabatanzi Musa Male Xiao-ying QU Yan-qiu LI Xie MENG Wu-shi DI Chang-zheng HUANG Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Dermatology No.457 Airforce HospitaU Wuhan 430012China Department of Dermatology Zhongshan Hospital Wuhan 430030China

Aneurysmal fibrous histiocytoma is often clinically *** this study,we put forward an insight on how to help diagnose this disease clinically.A retrospective chart review was performed on all patients diagnosed with aneuiysmal fibrous histiocytoma from 2007 to 2017 in the Department of Dermatology,Union Hospital,China,and all clinical data were collected from the hospital *** a total of 418 patients diagnosed with cutaneous fibrous histiocytoma,only 30 patients were confirmed to have aneurysmal fibrous histiocytoma out of which only 2 patients were clinically diagnosed with aneurysmal fibrous *** remaining 28 patients were diagnosed with various types of vascular tumors although pathology classified them as having aneurysmal fibrous *** the 30 patients,9 were male and 21 were *** were following age groups:13-19(mean 16,n=4),20-29(mean 26.25,n=8),30-39(mean 33,n=7),40-49(mean 44,n=4),50-59(mean 56.75,n=4)5 60 and above(mean 61,n=3).Tumors were present on the head,neck,back,waist,hips and upper and lower *** complete excision,there was no recurrence and no ***,lesions showed the typical pseudoangiomatoid spaces without endothelial lining and infiltration of fibrohistiocytes in hemosiderotic *** was suggested that although the prognosis of aneurysmal fibrous histiocytoma is good,accurate diagnosis is paramount to avoid clinical misdiagnosis and subsequent complications.

关键词： aneurysmal fibrous histiocytoma cutaneous fibrous histiocytoma

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Hsp70 confines tumor progression of rat histiocytoma and impedes the cytotoxicity induced by natural killer cells and peritoneal macrophages

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 302-309页

作者： Amere Subbarao Sreedhar Centre for Cellular and Molecular Biology Hyderabad 500 007India

Objective:To study the role of inducible form of heat shock protein 70(Hsp70) in the host tumor regression of rat tumor ***:We examined the role of Hsp70 in host tumorigenicity and in vitro cellular cytotoxicity using a rat *** differential tumor growth and regression kinetics were studied and correlated with the expression of Hsp70,activation of macrophages and natural killer(NK) cells,and circulating or tumor infiltrating immune molecules in the host ***:The sub cuteaneous(s.c.) tumor regression was correlated with increased serum cytokines such as IL-12,TNF P,IFNγand *** of similar increase of Hsp70 in intraperitoneal(i.p.) tumor implanted animals,animals succumb to tumor growth,further,evidently,no immune molecule activation was *** viral promoter driven Hsp70 over expression in these tumor cells restrained solid tumor growth,however,failed to inhibit ascites *** NK cells from *** animals induces cytotoxicity in the presence of anti-tumor antibody,which necessitated CD40-L expression,conversely,NK cells from *** animals failed to induce *** NK cells from *** *** animals with Hsp70 positive tumor cells failed to induce such *** peritoneal macrophages isolated from *** implanted animals when co-cultured with parental BC-8 cells lyses tumor cells,nevertheless entail macrophage specific TNFα*** the contrary,Hsp70 expressing BC-8 tumor cells were resistant to peritoneal macrophage induced ***:This study brings out that Hsp70 possibly involved in regulating the host tumor response and cellular cytotoxicity.

关键词： Hsp70 Rat histiocytoma NK cells Peritoneal macrophages Tumor

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CT FINDINGS OF MALIGNANT FIBROUS histiocytoma

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Chinese Journal of Cancer Research 1996年第4期8卷 267-271页

作者：戴景蕊石木兰李根柱吕宁 Cancer Institute (Hospital) Chinese Academy of Medical Sciences Peking Union Medical College Beijing

Purpose: To define the sites and CT findings of 45 MFH Patients. Materials and Methods: The primary sites were:cranio-facial 16, trunk and extremity 12 and abdominal 17 (13 retroperitoneal). As seen on CT scans, the lesion is clear-margined and even when small, but, when large (42/50,>5 cm), it is uneven in consistency and apt to invade the nearby organs (75.8%). The CT Findings of untreated and recurrent MFH are similar. Results:Enhanced CT scans may provide useful information such as medium to hyper-attenuation (78.8%), necrosis (60.6%)or involvement of para-nasal sinuses as expanding deformity (8/9 cases). Conclusions: CT scan is important to delineate the extent of MFH Iesions of which the diagnosis is best ascertained by combining CT scan and histopathology. Enhanced CT scans can reveal much useful information.

关键词： Fibrous histiocytoma Radiography,Mesenchymoma CT scan

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Primary hepatic malignant fibrous histiocytoma mimicking cystadenocarcinoma: a case report

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 620-623页

作者： Guang-Hui Ding Meng-Chao Wu Jia-He Yang Shu-Qun Cheng Nan Li Kai Liu Bing-Hua Dai Wen-Ming Cong Department of Comprehensive Treatment Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China. guanghuiding@***

BACKGROUND: Malignant fibrous histiocytoma is the most common sarcoma of soft tissue, which occurs usually in the extremities, but less common in the retroperitoneal space, abdominal cavity or other sites. Primary malignant fibrous histiocytoma of the liver is extremely rare; only 28 cases have been reported to date in the English literature.METHODS: In this report, a case of primary malignant fibrous histiocytoma of the liver was described in terms of clinical presentations, diagnosis and treatment and outcome.RESULTS: A 50-year-old man had a large multicystic-mass lesion in the left lobe of the liver, which was inoperable by laparotomy. Pathological examination of biopsy specimen after operation confirmed a malignant fibrous histiocytoma of storiform-pleomorphic type. The tumor developed rapidly, and the patient died of hepatic failure 2 months after the surgery.CONCLUSIONS: Primary malignant fibrous histiocytoma of the liver is diagnosed in late stage because of its rarity and non-specific presentations. Surgical resection, if feasible, is the first step treatment. The prognosis of primary malignant fibrous histiocytoma of the liver is grim with a median survival of 3 months as reported. Surgeons should be alert to the existence of this type of soft tissue tumor in the liver.

关键词： malignant fibrous histiocytoma liver differential diagnosis multicystic presentation

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Simultaneous occurrence of malignant fibrous histiocytoma and hepatocellular carcinoma in cirrhotic liver: A case report

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World Journal of Hepatology 2011年第9期3卷 256-261页

作者： Hee Sang Hwang Nam Du Ha Yoong Ki Jeong Jae Hee Suh Hye Jeong Choi Young Min Kim Hee Jeong Cha Department of Pathology University of Ulsan College of Medicine Asan Medical Center Department of Radiology University of Ulsan College of Medicine Ulsan University Hospital Department of Pathology University of Ulsan College of Medicine

Primary hepatic malignant fibrous histiocytoma (MFH) is rarely encountered. There have been no reports to date of hepatic MFH associated with liver cirrhosis. The presence of liver cirrhosis is considered an adjunctive feature favoring sarcomatoid hepatocellular carcinoma (HCC) in the diagnosis of spindle cell tumors in liver. We describe here a 59-year-old man with liver cirrhosis due to hepatitis B virus infection 20 years ago. On abdominal computed tomography scanning, two distinct hepatic masses were identified in the background of cirrhosis, which had different radiological features from conventional HCC. He underwent segmentectomy for removal of the tumors. The pathological examination of surgically resected specimen revealed the large malignant spindle cell tumor and small conventional HCC. Additional tissue sampling and immunohistochemical stainings demonstrated that the spindle cell tumor was consistent with MFH. On the post-operative follow-up for 21 mo, a round mass showing similar radiological findings for the previous MFH was appeared on the surface of resection margin, suggesting the recurrence. Despite its rarity, hepatic MFH should be considered during differential diagnosis, even in cirrhotic patients, and extensive tissue sampling and immunohistochemical analyses are necessary in the diagnosis of hepatic spindle cell tumors.

关键词： Liver neoplasm Malignant fibrous histiocytoma Hepatocellular carcinoma Liver cirrhosis

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DETECTION OF POINT MUTATION OF p53 GENE BY SILVER STAINING PCR-SSCP IN PARAFFIN-EMBEDDED MALIGNANT FIBROUS histiocytoma

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Chinese Journal of Cancer Research 1996年第3期8卷 39-42页

作者：李家良杨光华李甘地

Silver staining PCR-SSCP method was used to detect point mutation of p53 gene in paraffin-embedded malignant fibrous histiocytoma (MFH) tissues. The abnormal shifting of the single-stranded DNA (ssDNA) was identified in 9 out of 16 cases (56.3%). The positive figure of SSCP was 1, 4, 4, 3 in exon 5, 6, 7, 8, respectively. The mutant of p53 protein was detected by microwave oven treatment and ABC immunohistochemistry. Positive nuclear staining was observed in 10 cases (62.5%). The positive coincidence rate was 90.0% between SSCP and p53 protein expression. The mutation of p53 gene was not correlated with the subtypes of MFH. Our results indicate that detection of point mutations with silver staining PCR-SSCP is convenient, rapid and reliable in the screening of point mutation of genes.

关键词： histiocytoma Protein p53 Immuno-histochemistry Polymerase chain reaction Mutation.

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P53 pseudogene: potential role in heat shock induced apoptosis in a rat histiocytoma

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Health 2010年第9期2卷 1065-1071页

作者： Amere Subbarao Sreedhar 不详

The p53 tumor suppressor gene is either non- functional or highly and frequently mutated in majority of cancers. In our study towards understanding cellular adaptations to stress using a rat histiocytic tumor model, we have identified mis-sense mutation in p53 that led to premature termination of translation at the carboxyl-termi- nus. Further, the cDNA isolated from heat stre- ssed cells producing two amplicons with cDNA specific primers (N-terminus) suggested occurrence of possible pseudogene(s). A comparative analysis between different tumor cell lines of rat origin and rat genomic DNA using p53 gene specific primers resulted in the amplification of a processed pseudogene and its positive interaction with wild type p53 probe on Southern blot analysis. The genomic DNA sequence analysis, and sequence comparison with cDNA discovered that the processed pseudogene lacks DNA binding domain and nuclear localization signal, however, contains the ribosomal entry and stop signals. Rat genome BLAST analysis of the pesudogene suggested chromosome-18 localization which was in addition to 14, 13, 10, 9 localization of the cDNA. In the interest of unraveling hidden dimensions of p53 tumor suppressor gene, our study explores the probability of p53 functional pseudogenes in rat histiocytoma.

关键词： Pseudogene P53 Tumor Rat histiocytoma

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Primary malignant fibrous histiocytoma of the abdominal cavity:CT findings and pathological correlation

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World Journal of Radiology 2012年第4期4卷 151-158页

作者： Bivek Karki Department of Medical Imaging Nan fang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

AIM:To study computed tomography(CT)features of abdominal malignant fibrous histiocytoma(MFH)in various rare ***:We retroprospectively identified cases of MFH involving the abdominal *** attention was paid to details regarding imaging features and histological ***:The study population consisted of seven men and one woman,with a mean age of 52.5 *** patients had some physical symptoms,while one was incidentally *** sites of origin were liver(n=3),greater omentum(n=1),superior mesentery(n=1),ileum(n=1),right psoas muscle(n=1)and right kidney(n=1).With the exception of the ileum lesion,all were of huge *** contour of the lesions was more or less *** of necrosis were present in six lesions(n=6).On plain CT scan,all lesions were hypo to iso *** lesion in the greater omentum was *** lesion(n=1)showed significant enhancement and the cystic lesion showed mild peripheral *** abundance of blood vessels surrounding the mass was seen in two lesions(n=2)and both were of the inflammatory *** examination revealed storiform-pleomorphic variety(n=4),inflammatory variety(n=3)and myxoid variety(n=1).Two of the patients with inflammatory MFH had a clinical presentation of fever and one was afebrile,however,blood investigations in all three showed ***:Primary MFHs of the abdominal viscera and gastrointestinal tract are generally huge soft tissue masses containing areas of low attenuation and mild to moderate contrast enhancement.

关键词： Abdomen Computed tomography Malignant fibrous histiocytoma Soft tissue sarcoma

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Clinic Pathological Study of Aneurysmal Fibrous histiocytoma

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Journal of Biosciences and Medicines 2019年第5期7卷 1-5页

作者： Minna Gao Xiao Lin Department of Pathology Chongqing Medical University Chongqing China

Aneurysmal fibrous histiocytoma (AFH) is a rare variant of benign fibrous histiocytoma (FH), Characterized by blood-filled spaces within the fibrohistiocytic tumor. AFH has a higher recurrence rate than FH. The diagnosis of AFH is often problematic due to its overlapping morphological features with other skin tumors. The diagnosis of AFH depends on histological features and immunohistochemistry. The aim of this study is to understand the clinical and histopathological diagnostic criteria for AFH.

关键词： Aneurysmal Fibrous histiocytoma Clinical Pathology Diagnosis

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Pancreaticoduodenectomy for Pancreatic Metastases of Malignant Fibrous histiocytoma

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Surgical Science 2013年第11期4卷 506-508页

作者： Jing Zhu Huihua Cai Donglin Sun Department of Hepatobiliary Surgery The First People’s Hospital of Changzhou Soochow University Changzhou China

Unlike primary pancreatic carcinoma, metastases to the pancreas are rare and their resection may be performed as a palliative treatment due to poorly defined outcome. We herein present an extremely rare case of pancreatic metastases of malignant fibrous histiocytoma (MFH) undergoing pancreaticoduodenectomy with tumor-free survival within postoperative 35-month follow-up. Pancreatic resection for metastatic MFH to the pancreas should be considered in selected patients. Long-term survival or good palliation may be achieved.

关键词： Pancreaticoduodenectomy Pancreatic Metastasis Malignant Fibrous histiocytoma

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