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Erzhi pills ameliorates cognitive dysfunction and alter proteomic profiles of hippocampus in ovariectomized Alzheimer disease model rats induced by D-galactose and Aβ1-40 injection

引用

中国药理学与毒理学杂志 2021年第9期35卷 658-659页

作者： XIE Yong-yan HOU Min ZHOU Mao-fu YAN Bo LIU Chao YAO Li-hua SUN Men-sheng HE Kun FANG Cong CHEN Yao-hui HUANG Li-ping LIU Bo School of Pharmacy Jiangxi University of Traditional Chinese MedicineNanchang 330004China College of traditional Chinese medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004China the Second People′s Hospital of Jingdezhen Jingdezhen 333099China Shandong Qidu Pharmaceutical Co. Ltd.Zibo 255400China Jiangxi Provincial People′s Hospital Affiliated to Nanchang University Nanchang 330006China China Pharmaceutical University Nanjing 211198China School of Life Science Jiangxi Science&Technology Normal UniversityNanchang 330096China 不详

OBJECTIVE Erzhi pills is a clas⁃sic prescription of Chinese medicine originated from Fu Shou Jing Fang in Ming dynasty,with the effects of nourishing kidney-Yin and hemosta⁃sis,black hair,strengthening muscles and *** a classical prescription for nourishing kidney-Yin,Erzhi pills has been used to treat senile dementia in China for many ***,our study aimed to investigate the protective effects of Erzhi pills in rat models of Alzheimer disease(AD)induced by ovariectomy as well as D-galactose and Aβ1-40 injection and to explore its potential *** The model of AD rats was established by ovariectomy com⁃bined with D-galactose and Aβ1-40 *** rats were randomly divided into four groups:model group,estradiol valerate(0.80 mg·kg-1)group,Erzhi pills high(1.50 mg·kg-1)and low(0.75 mg·kg-1)doses *** addition,rats of sham operation were selected as the sham operated *** for the sham oper⁃ated group,rats were injected intraperitoneally with D-galactose(100 mg·kg-1 per day,for 49 d)on the 8th day,then they were given intracerebro⁃ventricular injection of Aβ1-40(10μg per rat,1 g·L-1)on the 36th day,while the corresponding drugs were given by gastrointestinal administra⁃tion on the 22nd *** our study,Morris water maze test was used to evaluate the learning and memory abilities,while ELISA kit was used to an⁃alyze serum estrogen *** morphology of hippocampal neuron cells was observed by HE staining,and Nissl staining was utilized to ob⁃serve the Nissl body in ***,the ex⁃pression of ERβpositive cells and hippocampal Aβ1-40 and p-Tau404 proteins was determined by *** order to further explore the molecular mechanism of Erzhi pills preven⁃tion and treatment of AD,proteomics was used to find potential targets and related pathways,Western blotting was used to verify the expres⁃sion of candidate differential *** to the results of proteomics in our experiment,Western blotting w

关键词： Erzhi pills Alzheimer disease hip⁃pocampal neurons proteomics estrogen aging memory PI3K/Akt signaling pathway

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