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A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family

Journal of Genetics and Genomics 2024年第9期51卷 900-910页

作者： Shuang Zhao Chen Wang Haiping Luo Feifei Li Qiang Wang Jin Xu Zhibin Huang Wei Liu Wenqing Zhang The Innovation Centre of Ministry of Education for Development and Diseases School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Greater Bay Biomedical Innocenter Shenzhen Bay LaboratoryShenzhenGuangdong 518055China

The hindbrain,which develops from the anterior end of the neural tube expansion,can differentiate into the metencephalon and myelencephalon,with varying sizes and *** midbrain–hindbrain boundary(MHB)and hindbrain myelencephalon/ventral midline(HMVM)are known to be the source of the progenitors for the anterior hindbrain and myelencephalon,***,the molecular networks regulating hindbrain morphogenesis in these structures remain *** this study,we show that retinoblastoma 1(rb1)is highly expressed at the MHB and HMVM in *** out rb1 in mice and zebrafish results in an enlarged hindbrain due to hindbrain neuronal *** study reveals that Rb1 controls the hindbrain morphogenesis by suppressing the expression of Gbx1/Gbx2,essential transcription factors for hindbrain development,through its binding to E2f3/Hdac1,***,we find that Gbx1 and Gbx2 are expressed in different types of hindbrain neurons,suggesting distinct roles in hindbrain *** summary,our study clarifies the specific role of RB1 in hindbrain neural cell proliferation and morphogenesis by regulating the E2f3–Gbx1 axis and the Hdac1–Gbx2 *** findings provide a research paradigm for exploring the differential proliferation of neurons in various brain regions.

关键词： Zebrafish hindbrain Rb1 Gbx1/Gbx2 Proliferation

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Response properties of the electrosensory neurons in hindbrain of the white sturgeon,Acipenser transmontanus

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Neuroscience Bulletin 2011年第6期27卷 422-429页

作者：张旭光 Hendrik Herzog 宋佳坤王晓杰范纯新郭弘艺上海海洋大学海洋生物系统与神经科学研究所上海201306 波恩大学动物研究所

Objective The passive electrosense is a primitive sensory modality in the Chondrostei, which include sturgeon and paddlefish. Using electroreceptors, these fish detect the weak electric fields from other animals or geoelectric sources, and use this information for prey detection or other behaviors. The primary afferent fibers innervating the electroreceptors project to a single hindbrain target called the dorsal octavolateral nucleus （DON）, where the electrosensory information is first processed. Here, we investigated the electrophysiological properties of DON neurons. Methods Extracellular recording was used to investigate the response properties of DON neurons to dipole electric fields with different amplitudes and frequencies in the white sturgeon, Acipenser transmontanus. Results The DON neurons showed regular spontaneous activity and could be classified into two types： neurons with a low spontaneous rate （〈10 Hz） and those with a high spon- taneous rate （〉10 Hz）. In response to sinusoidal electric field stimuli, DON neurons showed sinusoidally-modulated and phase-locked firing. In addition, neurons showed opposite phase responses corresponding to the different directions of the dipole. Conclusion The response properties of DON neurons match the electrosensory biological function in sturgeon, as they match the characteristics of the electric fields of its prey.

关键词： electrosense sturgeon dipole single unit hindbrain

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COEXISTENCE OF FOS-LIKE PROTEIN IN TYROSINE HYDROXYLASE-LIKE IMMUNOREACTIVE NEURONS IN THE hindbrain OF ARTS FOLLOWING PERIPHERAL ELECTRICAL STIMULATION

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Chinese Journal of Biomedical Engineering(English Edition) 1993年第1期2卷 39-45页

作者： Ji Rurong Fang Yuan Zhang Qin Han Jisheng, Department of Physiology, Beijing Medical University, Beijing 100083, China

In the present study we have found that proto-oncogene c-fos protein can expressin the noradrenergic neurons of rat hindbrain following peripheral electrical stimulation. Ratswere given peripheral electrical stimulation via thin stainless steel pins inserted into the pointsnear knee joint (S36) and ankle joint (Sp6) which mimic the manipulation of electroacupuncture(EA) performed in humans. Animals were perfused for double staining immunohistochemistry 2hafter the termination of EA. In rats subjected to EA stimulation Fos-like protein was found in thetyrosine hydroxylase (TH)-like immunoreactive neurons in rat hindbrain. The Fos and TH coex-isting neurons were distributed in the locus coeruleus, solitary tract nucleus, ventrolateral medul-la, periaqeductal gray, as well as superior colliculus. The percentage of the coexisting neuronscompared with the total number of neurons containing Fos-like protein in these nuclei rangedfrom 6% to 32%. The results suggest that the noradrenergic neurons in these regions may be ac-tivted by acupuncture stimulation.

关键词： Coexistence Fos-like protein tyrosine hydroxylase peripheral electrical stimu-lation electroacupuncture hindbrain

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N-CoR is required for zebrafish hindbrain patterning by actively repressing retinoid signaling

N-CoR is required for zebrafish hindbrain patterning by acti...

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中国遗传学会“发育、遗传和疾病”研讨会

作者： Fang Xu~1 Ping Hu~1 Kui Li~1 Wei Song~1 Jiong Chen~1 Xingxing Gu~2 Xiang Gao~1 Qingshun Zhao~(1,*) 1.Model Animal Research Center,Nanjing University,Nanjing,210061 2.Jiangsu Province Key Laboratory of Neuroregeneration,Nantong University,Nantong 226001

Limitation of retinoid signaling is essential to vertebrate hindbrain development.N-CoR(nuclear receptor co-repressor)is the first identified co-repressor that can repress retinoic acid(RA)target gene transcription in the absence of ***,N-CoR was reported to be required for mouse late-stage organogenesis;however,whether N-CoR can affect RA-responsive early embryonic patterning is unknown. In this study,we report molecular cloning of zebrafish orthologue of N-CoR and its wide distribution at zebrafish early *** or reducing N-CoR function by overexpressing N-CoR or dominant negative N-CoR(dnN-CoR)in zebrafish embryos alter the expression patterns of the transcription factors that are critical to hindbraln patterning and the length of hindbrain anterior-posterior axis,and these alterations are similar to those resulted from decreasing or increasing RA signaling in embryos respectively. When embryos are overexpressed with N-CoR or dnN-CoR together with retinoic acid receptor(RARa2b), the phenotypes are enhanced or suppressed *** together,our results demonstrate for the first time that N-CoR is essential for early hindbrain patterning by actively repressing retinoid signaling through RAR.

关键词： hindbrain nuclear receptor co-repressor retinoid signaling zebrafish

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Use of electrosense in the feeding behavior of sturgeons

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Integrative Zoology 2012年第1期7卷 74-82页

作者： Xuguang ZHANG Jiakun SONG Chunxin FAN Hongyi GUO Xiaojie WANG Horst BLECKMANN Institute for Marine Biosystem and Neuroscience Shanghai Ocean UniversityShanghaiChina College of Food Science and Technology Shanghai Ocean UniversityShanghaiChina Institute of Zoology University of BonnBonnGermany

The electro-receptive lateral line system appeared early in the evolutionary history of ***,members of the primitive Chondrostei group,are known for their electroreceptors(ampullae of Lorenzini)on the head,which are thought to be sensitive to weak electric fields in aquatic environments and involved in feeding,mating and ***,we report the results of a set of behavioral and electrophysiological experiments designed to determine the function and characteristics of the electrosense in cultured *** results showed Sibe-rian sturgeon(Acipenser baerii Brandt,1869)feeding striking at bio-electric fields produced by living feed-fish enclosed in a gel chamber and at the corrosion field produced by metal *** an electric stimulus that mim-ics the bio-electric fields produced by living prey,the relative discharge rate of electrosensory neurons in the dorsal octavolateralis nucleus(DON)was modulated by and phase-locked to sinusoidal stimulus and some units showed selectivity for dipolar direction in white sturgeon(Acipenser transmontanus Richardson,1836).This is the first study to provide the empirical evidence correlating with electrosensory behaviors and electrophysiolog-ical responses in cultured sturgeons,and suggesting that electrosense does play an innate role in feeding behav-ior of *** believe this will have important implications for protecting sturgeons in the wild.

关键词： behavior dipole electrosense hindbrain sturgeon

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Does sturgeon do use electrosense in predating?

Does sturgeon do use electrosense in predating?

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hendrik Herzog Institute of zoology University of BonnPoppelsdorfer SchlossBonn 53115Germany

＜正＞Objective The electro-receptive lateral line system appears in the early evolutionary history of *** of the primitive Chondrostei fish group,sturgeon,is well known to have the electroreceptors（the ampullay Lourenzeni organs） on the *** were thought to be sensitive to weak electric fields in aquatic environment and being used in behaviors of prey detecting,mating,and migrating;however,there was little experimental evidence could find directly to support the *** Here we report our results of behavioral and electrophysiological experiments that are specifically designed to investigate the function and characters of the electrosensory in ***,we record the electronic characters of the bio-electrical field of their living ***,we investigate the behavioral pattern of the Siberian Sturgeon,Acipenser baerii in response to the identified bio-electrical field（produced by embedding the living prey fish in the gel chamber）.Third,we record the response properties of the electrosensory neurons in the hind brain from the dorsal octavolateralis nucleus（DON） of the White Sturgeon,Acipenser transmontanus with the simulating sinusoidal electric field according to the identified characters of the bio-electrical field produced by living prey. Results（1） The bio-electrical field of prey fish presented as direct current electric field of dipole type with negative potential on head and positive potential on tail and modulated into alternating electric field by respiration rhythm;（2） During the stimulation,DON units increased their firing rate and phase coupled the stimulation wave and showed the selectivity of dipolar *** These behavioral and electrophysiological results are first solid evidence to point out that the electrosense of Sturgeon does being used in predating（feeding） behavior.

关键词： electrosense sturgeon behavior dipole hindbrain

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