检索结果-南通市图书馆

The application of high resolution seismic data processing technique in multi-channel shallow offshore engineering seismic surveys

在线全文

cnki会议

学校读者我要写书评

暂无评论

The application of high resolution seismic data processing t...

The 2nd International Conference on Environmental and Engineering Geophysics

作者： Qingsheng Meng Zhijie Ma Yonggang Jia Xiujun Guo Yuqing Fan Xinbin Zhang Ocean University of China Qingdao 266003 China Graduate School of China University of Geosciences Wuhan 430074 China

＜正＞The high resolution data processing technique of shallow seismic is an important aspect for the engineering geophysical surveys either in land or ocean. In this paper, we present two methods to improve the resolution and Signal-to-Noise rate of offshore engineering seismic data, which are high resolution velocity analysis and KL-transform multiple removal. Coupled with the drilling information, the result showed the excellent accuracy, and solved the engineering geology problems efficiently.

关键词： high resolution data processing velocity analysis multiple removal

Development of high-resolution Time-of-Flight Mass Spectrometry–Theoretical and Experimental Study

在线全文

cnki会议

学校读者我要写书评

暂无评论

Development of High-Resolution Time-of-Flight Mass Spectrome...

2018年中国质谱学术大会（CMSC2018）

作者： Yu-Meng Ou Yi-Hong Cai Cheng-Huang Lin Yi-Sheng Wang "Genomics Research Center Academia Sinica" Chemistry Department Taiwan University Department of Chemistry Taiwan Normal University

high-resolution mass spectrometry is fundamental to high-quality analysis. Time-of-flight(TOF) mass analyzer is the most efficient mass analyzer providing high-quality data, and its mass resolving power(R) is only next to Fourier-Transform mass analyzers. Recently we have analyzed critical factors determining the R of a linear TOF mass analyzer based on a comprehensive calculation method.1, 2 The calculation predicted a well-designed instrument can improve the R by 1-2 orders of magnitude, whereas the total flight distance is kept unchanged. We will discuss the essential parameters effecting the R of matrix-assisted laser desorption/ionization(MALDI) TOF mass spectrometers using the flight time topology. A general expression of the time-domain spectral feature considering the Maxwell-Boltzmann initial velocity distribution was developed, allowing efficient analysis of instrumental conditions. The configuration of a laboratory-made MALDI-TOF mass spectrometer was optimized based on the prediction providing the highest Rm. Although the instrument is a linear TOF analyzer, observation shows a higher R than conventional reflectron TOF mass spectrometers is routinely available. Further limitations restrict the R are discussed.

关键词： high resolution time-of-flight mass spectrometer theoretical calculation flight time topology initial velocity

Direct resolution of the Pitch of DNA on Positively Charged Lipid Bilayers by Frequency-Modulation AFM

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2014年第5期19卷 565-568页

作者：张金金吕军鸿孙洁林胡钧 CZAJKOWSKY Daniel M 沈轶 Laboratory of Physical Biology Shanghai Institute of Applied PhysicsChinese Academy of Sciences School of Biomedical Engineering Shanghai Jiaotong University Key Laboratory of Systems Biomedicine Shanghai Jiaotong University

high resolution structural studies of DNA and DNA binding proteins by atomic force microscopy(AFM) require well-bound samples on suitably flat substrates. Adsorbing the DNA onto a positively charged supported lipid bilayer has previously been shown to be a potentially effective strategy for structural studies with AFM. Here, using our home-built frequency-modulation AFM(FM-AFM), we show that these bilayer substrates are only maximally effective for high resolution AFM when the samples are short, linear DNA, compared with circular plasmid DNA. We find that, with the former sample, the measured width of the DNA is about 2 nm, the known DNA diameter, and there is a clear height modulation along the length of the DNA with a periodicity of about 3.4 nm, in excellent agreement with the known pitch of the double helix. This sample preparation strategy is expected to enable higher resolution studies of DNA and DNA binding proteins with FM-AFM than that can presently be achieved.

关键词： frequency-modulation atomic force microscopy(FM-AFM) DNA double helix high resolution

Experimental research of traveling wave type rotary ultrasonic motor with high resolution

在线全文

学校读者我要写书评

暂无评论

Experimental research of traveling wave type rotary ultrason...

2011年全国压电和声波理论及器件应用研讨会

作者： Chao CHEN,Zhijun SUN State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics.NanJing 210016,CHINA

＜正＞As a novel piezoelectric actuator,traveling wave type rotary ultrasonic motor（TRUM） has a high ratio of torque to weight,fast response.It has also inherently high torque and low speed output,so that speed reducing gears usually can be avoided.TRUM also are of compact size,in particular also high step resolution,which can be used for precise

关键词： traveling wave ultrasonic motor high resolution step

Comprehensive Analysis of Acylcarnitine Species in db/db Mouse Using a Novel Method of high-resolution Parallel Reaction Monitoring Reveals Widespread Metabolic Dysfunction Induced by Diabetes

在线全文

cnki会议

学校读者我要写书评

暂无评论

Comprehensive Analysis of Acylcarnitine Species in db/db Mou...

2018年中国质谱学术大会（CMSC2018）

作者： Li Xiang Juntong Wei Zongwei Cai Yu Huang School of Biomedical Sciences and Institute of Vascular Medicine Chinese University of Hong Kong State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist University

Acylcarnitines are exerting a variety of biological functions depending on the differences in lengths, saturation levels, and conjugation groups, which to a great extent contribute to the challenges of acylcarnitines quantifications due to various kinds of isomers. Here, we describe a novel method by using high-resolution parallel reaction monitoring(PRM) liquid chromatography-tandem mass spectrometry(LC-MS/MS). Both reversed phase and normal-phase column were used in order to get accurate, reliable, widespread quantification of acylcarnitines, and without tedious sample preparation procedure. The method provided the most comprehensive acylcarnitine profile with high-resolution MS and MS/MS confirmation to date. A total of 117 acylcarnitines were detected from plasma and urine samples. The application of targeted profiling of acylcarnitines in db/m+ control and db/db diabetic mice indicated incomplete amino acid and fatty acid oxidation on diabetic mice. Interestingly, the reduction of medium odd-numbered chain acylcarnitines in urine samples was first observed between db/m+ and db/db mice. The high-resolution PRM method makes it possible to monitor the widespread metabolic changes of the acylcarnitines in response to stimuli. Besides, the accurate MS and MS/MS spectra data of the 117 acylcarnitines could be used as mass spectrometric resources for the identification of acylcarnitines.

关键词： Parallel reaction monitoring acylcarnitines db/db high resolution LC/MS

HDL quality features revealed by proteome–lipidome connectivity are associated with atherosclerotic disease

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2022年第3期14卷 12-22页

作者： Dandan Wang Bilian Yu Qingrun Li Yanhong Guo Tomonari Koike Yui Koike Qingqing Wu Jifeng Zhang Ling Mao Xiaoyu Tang Liang Sun Xu Lin Jiarui Wu Y.Eugene Chen Daoquan Peng Rong Zeng CAS Key Laboratory of Systems Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China Department of Cardiovascular Medicine the Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Internal Medicine Cardiovascular CenterUniversity of Michigan Medical CenterAnn ArborMI 48109USA Key Laboratory of Nutrition and Metabolism Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Systems Biology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China

Lipoprotein,especially high-density lipoprotein(HDL),particles are composed of multiple heterogeneous subgroups containing various proteins and lipids.The molecular distribution among these subgroups is closely related to cardiovascular disease(CVD).Here,we established high-resolution proteomics and lipidomics(HiPL)methods to depict the molecular profiles across lipoprotein(Lipo-HiPL)and HDL(HDL-HiPL)subgroups by optimizing the resolution of anion-exchange chromatography and comprehensive quantification of proteins and lipids on the omics level.Furthermore,based on the Pearson correlation coefficient analysis of molecular profiles across high-resolution subgroups,we achieved the relationship of proteome–lipidome connectivity(PLC)for lipoprotein and HDL particles.By application of these methods to high-fat,high-cholesterol diet-fed rabbits and acute coronary syndrome(ACS)patients,we uncovered the delicate dynamics of the molecular profile and reconstruction of lipoprotein and HDL particles.Of note,the PLC features revealed by the HDL-HiPL method discriminated ACS from healthy individuals better than direct proteome and lipidome quantification or PLC features revealed by the Lipo-HiPL method,suggesting their potential in ACS diagnosis.Together,we established HiPL methods to trace the dynamics of the molecular profile and PLC of lipoprotein and even HDL during the development of CVD.

关键词： HDL high resolution proteomics lipidomics atherosclerotic disease

Review of bio-optical imaging systems with a high space-bandwidth product

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced Photonics 2021年第4期3卷 1-18页

作者： Jongchan Park David J.Brady Guoan Zheng Lei Tian Liang Gao University of California Department of BioengineeringLos AngelesCaliforniaUnited States University of Arizona James C.Wyant College of Optical SciencesTucsonArizonaUnited States University of Connecticut Department of Biomedical EngineeringStorrsConnecticutUnited States University of Connecticut Department of Electrical and Computer EngineeringStorrsConnecticutUnited States Boston University Department of Electrical and Computer EngineeringBostonMassachusettsUnited States

Optical imaging has served as a primary method to collect information about biosystems across scales—from functionalities of tissues to morphological structures of cells and even at biomolecular levels.However,to adequately characterize a complex biosystem,an imaging system with a number of resolvable points,referred to as a space-bandwidth product(SBP),in excess of one billion is typically needed.Since a gigapixel-scale far exceeds the capacity of current optical imagers,compromises must be made to obtain either a low spatial resolution or a narrow field-of-view(FOV).The problem originates from constituent refractive optics—the larger the aperture,the more challenging the correction of lens aberrations.Therefore,it is impractical for a conventional optical imaging system to achieve an SBP over hundreds of millions.To address this unmet need,a variety of high-SBP imagers have emerged over the past decade,enabling an unprecedented resolution and FOV beyond the limit of conventional optics.We provide a comprehensive survey of high-SBP imaging techniques,exploring their underlying principles and applications in bioimaging.

关键词： space-bandwidth product bioimaging gigapixel imaging high resolution wide field of view

Quantitative ultrasound brain imaging with multiscale deconvolutional waveform inversion

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2023年第1期32卷 362-372页

作者：李玉冰王建苏畅林伟军王秀明骆毅 Institute of Acoustics Chinese Academy of SciencesBeijing 100190China University of the Chinese Academy of Sciences Beijing 100049China Beijing Deep Sea Drilling Measurement Engineering Technology Research Center Beijing 100190China

high-resolution images of human brain are critical for monitoring the neurological conditions in a portable and safe manner.Sound speed mapping of brain tissues provides unique information for such a purpose.In addition,it is particularly important for building digital human acoustic models,which form a reference for future ultrasound research.Conventional ultrasound modalities can hardly image the human brain at high spatial resolution inside the skull due to the strong impedance contrast between hard tissue and soft tissue.We carry out numerical experiments to demonstrate that the time-domain waveform inversion technique,originating from the geophysics community,is promising to deliver quantitative images of human brains within the skull at a sub-millimeter level by using ultra-sound signals.The successful implementation of such an approach to brain imaging requires the following items:signals of sub-megahertz frequencies transmitting across the inside of skull,an accurate numerical wave equation solver simulating the wave propagation,and well-designed inversion schemes to reconstruct the physical parameters of targeted model based on the optimization theory.Here we propose an innovative modality of multiscale deconvolutional waveform inversion that improves ultrasound imaging resolution,by evaluating the similarity between synthetic data and observed data through using limited length Wiener filter.We implement the proposed approach to iteratively update the parametric models of the human brain.The quantitative imaging method paves the way for building the accurate acoustic brain model to diagnose associated diseases,in a potentially more portable,more dynamic and safer way than magnetic resonance imaging and x-ray computed tomography.

关键词： ultrasound brain imaging full waveform inversion high resolution digital body

A current-steering self-calibration 14-bit 100-MSPs DAC

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2010年第12期31卷 129-133页

作者：邱东方盛李冉谢任重易婷洪志良 State Key Laboratory of ASIC and System Fudan University

This paper presents the design and implementation of a 14-bit, 100 MS/s CMOS digital-to-analog converter （DAC）. Analog background self-calibration based on the concept of analog current trimming is introduced. A constant clock load switch driver, a calibration period randomization circuit and a return-to-zero output stage have been adopted to improve the dynamic performance. The chip has been manufactured in a SMIC 0.13-μm process and occupies 1.33 × 0.97 mm2 of the core area. The current consumption is 50 mA under 1.2/3.3 V dual power supplies for digital and analog, respectively. The measured differential and integral nonlinearity is 3.1 LSB and 4.3 LSB, respectively. The SFDR is 72.8 dB at a 1 MHz signal and a 100 MHz sampling frequency.

关键词： DAC high speed high resolution self-calibration calibration period randomization