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Mitochondria-targeting NIR fluorescent probe for rapid,highly sensitive and selective visualization of nitroxyl in live cells,tissues and mice

引用

Science China Chemistry 2020年第2期63卷 282-289页

作者： Jianguo Wang Wenping Zhu Chunbin Li Pengfei Zhang Guoyu Jiang Guangle Niu Ben Zhong Tang College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China Key Laboratory of Organo-Pharmaceutical Chemistry Gannan Normal UniversityGanzhou 341000China Department of Chemistry The Hong Kong University of Science&TechnologyClear Water BayKowloonHong Kong 999077China HKUST-Shenzhen Research Institute Shenzhen 518057China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055China

Nitroxyl(HNO)has been reported to possess unique biological and pharmacological performances,and emerged as a novel therapy for congestive heart *** studies also suggest that HNO may be produced and involved in important metabolisms in ***,due to its high reactivity and short life properties,fast,sensitive and selective observation and monitoring of HNO related dynamic changes in mitochondria still remains a great ***,we synthesized a mitochondria-targeting near-infrared(NIR)fluorescent probe(DCMHNO)for rapid detection of HNO with remarkably high sensitivity,selectivity and *** shows fast response(about 4 min)towards HNO via 2-(diphenylphosphino)benzoyl group through the Staudinger reaction to boost the bright NIR emission(700 nm)with excellent sensitivity(detection limit of 13 nM),high p H stability and very low interference from other *** can selectively locate in mitochondria and visualize exogenous and endogenous HNO in live He La cells with high biocompatibility and *** probe could also monitor the interaction between NO and H2 S that gives rise to the generation of HNO in live He La *** addition,DCMHNO was further utilized in ex vivo NIR imaging of HNO in live mouse liver tissues at the depth of about 50μ*** vivo imaging of HNO with high signal-to-noise ratio in live mice was also realized by using *** remarkable imaging performances could render NIR DCMNHNO as a useful tool to reveal HNO related dynamic changes in live samples.

关键词： fluorescent probe mitochondria-targeting nitroxyl near-infrared high photostability

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