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Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao SU Meng-qing LI Lan YU Ai-ling CHEN Ken HUANG Yun-ke ZHAO Qiu-long HUANG Wen-ya HUANG Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,P<0.01)and endothelial function-protective(lower VEGF,ET-1,P<0.01)*** increases in aortic relaxation,endothelial NO levels and phosphorylated PI3K/Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity

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Chinese Chemical Letters 2014年第7期25卷 1039-1043页

作者： Guang-Yue Hou Lu Wang Shu Liu Feng-Rui Song Zhi-Qiang Liu Changchun Center of Mass Spectrometry & Chemical Biology Laboratory Changchun Institute of Applied ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences

The formation of advanced glycation end-products （AGEs） and aldose reductase （AR） activity have been implicated in the development of diabetic complications. Our study sought to characterize the capacities of eleven herbal extracts against the formation of AGEs and the AR activity. An ultrahigh performance liquid chromatography and tandem mass spectrometry （UPLC-MS/MS） method was used for the detection of AR activity and the screening of AR inhibitors in this research. The amount of sorbitol from each analyte was directly detected using the multiple reaction monitoring mode and the sorbitol level could be reduced via the addition of an inhibitor. Moreover, the BSA/glucose （fructose） system was applied to investigate their inhibitory activities of AGEs formation in glycation model reactions. Compared with other screened herbs used in our study, Flos Sophorae lrnrnaturus and Radix Scutellariae seemed to be more effective on inhibiting the formation of AGEs and AR activity. The inhibiting capacities of herbal extracts against AR activity and AGEs formation may be correlated with the bioactive components of the herbal extracts. The differences were correlated with the amount of polyphenol and flavonoid components. In the study, we have investigated the potential anti-hyperglycemic bioactivity of eleven herbal extracts in vitro, which could provide a reference for further in vivo research in the prevention and treatment of diabetic complications.

关键词： herbal extract Aldose reductase Advanced glycation end-products Ultrahigh performance liquidchromatography-tandem massspectrometry

An Overview of the Use of Medicinal Plants in Regenerative Dentistry

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Open Journal of Stomatology 2023年第1期13卷 50-88页

作者： Sara Dhoum Samir Ibenmoussa Mustapha Sidqui Faculty of Dental Medicine Hassan II University Casablanca Morocco Faculty of Medicine and Pharmacology Hassan II University Casablanca Morocco

Aim: The oral cavity has the particularity to host multiple hard and soft tissues, in this paper, we will discuss the current therapies that lead to cell differentiation by regenerative therapies and the future alternatives proposed by medicinal plants and all the regenerative potential of these different tissues. Material and Methods: A detailed review of the literature through the various search engines: Scopus, PubMed, google scholar, Cochrane, etc., uses the selected keywords to explore the effect of the regenerative potential of several medicinal plants. Results: Through our research, we have proceeded to sort different medicinal plants, according to their repairing and regenerative potential on the different tissues of the oral cavity. Conclusion: Future studies are conceivable to explore the opportunities and potential provided by medicinal plants in the field of regenerative dentistry.

关键词： Medicinal Plants Medicinal Herbs Tissue Regeneration Enamel Remineralization Dental Pulp Periodontal Regeneration Bone Regeneration Wound Healing Stem Cells Differentiation Odontoblastic Differentiation Oral Cavity herbal extract Oral Tissues

A Cardiomyopeptin Preparation Protects against Isoproterenol-Induced Chronic Heart Failure in Rats

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Chinese Medicine 2023年第4期14卷 242-254页

作者： Zumeng Xia Hoi Yan Leung Hoi Ling Siu Chung Wai Chan Kam Ming Ko R&D Center Infinitus China Limited Guangzhou China Division of Life Science Hong Kong University of Science & Technology Hong Kong China

The present study investigated the effect of an herbal extract-supplemented cardiomyopeptin preparation (HECP), in the rat model of chronic heart failure. HECP pre-/co-treatment at a daily dose of 0.072 to 0.124 g/kg for 30 days protected against isoproterenol (ISO)-induced chronic myocardial damage in rats in a dose-dependent manner, with the extent of protection, as assessed by plasma cardiac troponin I level, being up to 76%. The cardioprotection afforded by HECP was associated with the enhancement of myocardial mitochondrial antioxidant status, amelioration of plasma parameters on cardiac dysfunction and hypertrophy, as well as an increase in myocardial endothelial nitric oxide synthase activity. Myocardial apoptotic and anti-apoptotic parameters were suppressed and stimulated, respectively. The cardioprotection afforded by HECP was accompanied by an increase in exercise capacity, an indirect functional index of the myocardium, in ISO-challenged rats. In conclusion, HECP may offer a promising prospect in preventing chronic heart failure in human subjects.

关键词： Cardiomyopeptin herbal extract Chronic Heart Failure Isoproterenol

Rauwolfia vomitoria extract suppresses benign prostatic hyperplasia by reducing expression of androgen receptor and 5a-reductase in a rat model

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Journal of Integrative Medicine 2021年第3期19卷 258-264页

作者： Tian Fang Ze-sheng Xue Jia-xuan Li Jia-kuan Liu Di Wu Mei-qian Li Yu-ting Song Shi-feng Yun Jun Yan Department of Comparative Medicine Jinling HospitalNanjing University School of MedicineNanjing 210002Jiangsu ProvinceChina Center for Veterinary Drug Research and Evaluation College of Veterinary MedicineNanjing Agricultural UniversityNanjing 210095Jiangsu ProvinceChina Model Animal Research Center of Nanjing University Nanjing 210061Jiangsu ProvinceChina Department of Laboratory Animal Science Fudan UniversityShanghai 200032China Ministry of Education Key Laboratory of Model Animals for Disease Study Model Animal Research Center of Nanjing UniversityNanjing 210061Jiangsu ProvinceChina Department of Information Jinling HospitalNanjing University School of MedicineNanjing 210002Jiangsu ProvinceChina

Objective:herbal medicine is an important therapeutic option for benign prostatic hyperplasia(BPH),a common disease in older men that can seriously affect their quality of ***,it is crucial to develop agents with strong efficacy and few side *** we investigated the effects of the extract of Rauwolfia vomitoria,a shrub grown in West Africa,on ***:Rats with testosterone-induced BPH were treated with *** were histologically analyzed by Hematoxylin and eosin *** index and the expression levels of androgen receptor and its associated proteins were quantified through immunohistochemistry and *** receptor target genes were examined by quantitative real-time polymerase chain *** sperm count and body weight of rats were also ***:The oral administration of *** extract significantly reduced the prostate weight and prostate weight index in BPH rats,supported by the decreased thickness of the prostate epithelial layer and increased lumen *** effects were observed in the BPH rats treated with the reference drug,*** extract significantly reduced the testosterone-induced proliferation markers,including proliferating cell nuclear antigen and cyclin D1,in the prostate glands of BPH rats;it also reduced levels of androgen receptor,its associated protein steroid 5 a-reductase 1 and its downstream target genes(FK506-binding protein 5 and matrix metalloproteinase 2).Notably,compared with the finasteride group,*** extract did not significantly reduce sperm ***:*** suppresses testosterone-induced BPH *** to its milder side effects,*** could be a promising therapeutic agent for BPH.

关键词： Benign prostatic hyperplasia Rat model herbal extract Androgen receptor Rauwolfia vomitoria

Multivariate modeling to evaluate effect of fabricating process on product profile of high shear granulation

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Chinese herbal Medicines 2018年第4期10卷 396-404页

作者： Zheng Yan Ying-ying Gong Liang-shan Ming Yi-hui Xie Jiangxi University of Traditional Chinese Medicine Nanchang 330004China Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai University of Traditional Chinese Medicine Shanghai 201203China

Objective： To investigate the feasibility of high shear granulation（HSG） for agglomeration of Crataegi Folium extract（Chinese edible herbal）, and explore the effect of process variables on granule critical quality attributes（CQAs） by three different models, i.e., response surface methodology（RSM）, multilayer perceptron neural networks（MLP）, and partial least squares method（PLS）.Methods： RSM, MLP, and PLS complementary to design of experiment（DoE） were utilized to investigate the influence of granulation time, impeller speed, and binder amount on the products. Crataegi Folium extract was employed as granulation powder. RSM was further carried out to develop design space of ***： The results indicated that RSM, MLP, and PLS modeling techniques enhanced the understanding and controlling of granules produced via HSG. The granule CQAs were mainly influenced by granulation time, impeller speed, and binder amount. Overlay plots of the RSM indicated that design space for the operating ranges of impeller speed and binder amount at high levels of granulation time was the ***： The study showed that these models were useful to characterize the granulation process, and was particularly important to understand the process.

关键词： central composite design Crataegi Folium design space herbal extract modeling

Human pulp tissue dissolution ability of different extracts of Sapindus mukorossi: An in vitro study

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Chinese herbal Medicines 2020年第2期12卷 178-182页

作者： Öznur Güçlüer Esin Akarsu Emre Yavuz Kürsat Er Alper Kustarcl Department of Endodontics Faculty of DentistryAkdeniz UniversityAntalya 07070Turkey Department of Chemistry Faculty of ScienceAkdeniz UniversityAntalya 07070Turkey

Objective:Due to the many negative properties of sodium hypochlorite used in current root canal treatment,interest in biocompatible natural agents is increasing day by *** aim of this study was to evaluate whether various extract solutions of Sapindus mukorossi have dissolution effects on human pulp ***:Primarily powder extracts were obtained by extracting fruit shells of *** in different solvents(ethanol,methanol,buthanol and distilled water).The test solutions were prepared and randomly separated into six groups with 10 samples in each group:ethanol extract,methanol extract,butanol extract,distilled water extract of ***,sodium hypochlorite(Na OCl)and the control *** these,*** extracts were separated into two subgroups,depending on their concentration level(50μg/m L and 100μg/m L).The pulp tissues of freshly extracted human molars were used for dissolution *** weights of the pulpal tissues were measured and recorded for two times after the samples were placed in the *** analysis for all descriptive statistics was performed using SPSS 22(Pextract of *** all of the groups,the best dissolution capacity was seen in the Na OCl group(positive control group).Among *** groups,the best tissue solvent solution was found in SMM group at 50μg/m L and SMB group at 100μg/m ***:The different extracts of *** had a capacity to dissolve pulp tissue but this capacity was less than Na ***,further studies will enable the creation of a commercial solution for clinical use by increasing the effectiveness of *** while combining it with other endodontic irrigation solutions.

关键词： dissolution herbal extract human pulp tissue NaOCl Sapindus mukorossi Gaertn