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Incidental Collision Tumor of hepatocellular carcinoma and Neuroendocrine carcinoma

Journal of Clinical and Translational Hepatology 2018年第3期6卷 339-344页

作者： Düriye Betül Yilmaz Zeynep Bayramoglu Gülsah Ünay Erdem Ayik Cumhur Ibrahim Bassorgun Gülsüm Ozlem Elpek Department of Pathology Akdeniz University Medical SchoolKonyaalti/AntalyaTurkey

The composite tumors of the liver are very rare,including the coexistence of HCC(hepatocellular carcinoma)with NEC(neuroendocrine carcinoma).The rare occurrence of these tumors necessitates more reported cases in order to fully understand their clinical characteristics,behaviors and *** is described an incidental collision tumor of HCC-NEC,along with a review of the literature focusing on their clinicopathological findings and *** tumor presented here was found incidentally in the hepatectomy specimen of a 56-yearold man who had undergone liver transplantation for rapidly progressive liver failure because of alcoholic hepatitis and *** and laboratory examinations did not demonstrate tumor-related *** macroscopic examination,two sharply defined and distinctive areas(1.7 cm and 0.6 cm dimension respectively)were detected among the cirrhotic *** characteristic histopathological features and immunohistochemical findings allowed a diagnosis of HCCNEC to be *** was no evidence of recurrence and metastasis after 10months following *** present case and review revealed that these tumors are frequently found in older ages and *** serum markers are valuable in the discrimination of malignant tumors,their absence cannot completely rule out composite *** requires a comprehensive histopathological evaluation together with *** NEC component might influence the treatment strategy and eventually the outcome of the *** conclusion,the rare occurrence of HCC-NEC and the lack of diagnostic clinical signs and symptoms do not exclude their consideration in the differential diagnosis of liver tumors,especially in patients with the chronic liver disease.

关键词： Liver neoplasm hepatocel ular carcinoma Neuroendocrine carcinoma

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Liver Transplantation for Hepatitis B Virus-related hepatocellular carcinoma in Hong Kong

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Journal of Clinical and Translational Hepatology 2018年第3期6卷 283-288页

作者： Ka Wing Ma Kenneth Siu Ho Chok James Yan Yue Fung Chung Mau Lo Department of Surgery The University of Hong KongHong KongChina State Key Laboratory for Liver Research The University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina

hepatocellular carcinoma(HCC)is the fifth most common cancer and the third most common cause of cancer-related deaths *** resection is frequently limited in Hong Kong by hepatitis B virus-related cirrhosis,and liver transplantation is the treatment of *** transplanta-tion has been shown to produce superior oncological benefits,when compared to hepatectomy for *** developments in the context of patient selection criteria,modification of organ allocation,bridging therapy,salvage liver transplanta-tion and pharmaceutical breakthrough have improved the survival of HCC *** this article,we will share our experience in transplanting hepatitis B virus-related HCC patients in Hong Kong and discuss the recent progress in several areas of liver transplantation.

关键词： Liver transplantation Hepatitis B hepatocel ular carcinoma Review

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Saikosaponin-b regulates the proliferation and apoptosis of HepG2 cells by targeting the MACC1/c-Met/Akt signaling pathway

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中国药理学与毒理学杂志 2017年第10期31卷 965-966页

作者： Xing-zhi LYU Rui-fang LI Zi-han GAO Hong-wei WANG Sang-qiang LI Jian-gang WANG Laboratory of Pharmacology and Molecular Biology Medical CollegeHenan University of Science and Technology School of Nursing Henan University of Science and Technology

OBJECTIVE Metastasis-associated in colon cancer-1(MACC1)is an oncogene that has been newly *** promotes tumor proliferation and invasion via the MET *** study investigated the effects of Saikosaponin-b(SS-b)on the proliferation and apoptosis of HepG2 cells and its regulation on MACC1/c-Met/Akt signaling *** HepG2 cells were treated with SS-b(10-800 g·L^(-1))for 48 h in *** CCK-8 assay was used to assess cell proliferation,and cell apoptosis was determined by Hoechst33258 staining,AnnexinⅤ/PI staining and caspase 3 ***-PCR was used to examine the expression of MACC1,c-MET and hepatocyte growth factor(HGF)mR ***1 protein was detected by Western blot and *** protein expressions of p-cMET,c-MET,p-AKT,AKT,p-BAD,BAD were measured by Western *** SS-b inhibited the growth of HepG2 cells in dose-dependent way and induced cell apoptosis ***2 cells showed karyopyknosis,fragmentation and fluorescence highlight in SS-b treatment *** results showed that apoptosis rate of HepG2 cells increased with SS-b *** immunofluorescence results showed that the MACC1 expression decreased significantly in HepG2 cells treated with *** expression levels of MACC1,c-MET and HGF mR NA in HepG2 cells were significantly inhibited by ***-b also significantly decreased the protein expressions of MACC1,p-c-MET and p-AKT while increased the expression of p-BAD and caspase 3 in HepG2 cells(P<0.05).CONCLUSION SS-b inhibited the proliferation and induced the apoptosis of HepG2 cells by targeting the MACC1/c-Met/Akt signaling pathway.

关键词： saikosaponin-b metastasis-associated in colon cancer-1 c-Met signaling hepatocel ular carcinoma

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