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hepatitis b virus molecular biology and pathogenesis

Hepatoma Research 2016年第1期2卷 163-186页

作者： R.Jason Lamontagne Sumedha bagga Michael J.bouchard Department of biochemistry and Molecular biology Drexel University College of MedicinePhiladelphiaPA 19102USA The Wistar Institute PhiladelphiaPA 19104USA

As obligate intracellular parasites,viruses need a host cell to provide a milieu favorable to viral ***,viruses often adopt mechanisms to subvert host cellular signaling *** beneficial for the viral replication cycle,virus-induced deregulation of host cellular signaling processes can be detrimental to host cell physiology and can lead to virus-associated pathogenesis,including,for oncogenic viruses,cell transformation and cancer *** among these oncogenic viruses is the hepatitis b virus(HbV).Despite the availability of an HbV vaccine,350-500 million people worldwide are chronically infected with HbV,and a significant number of these chronically infected individuals will develop hepatocellular carcinoma(HCC).Epidemiological studies indicate that chronic infection with HbV is the leading risk factor for the development of ***,HCC is the second highest cause of cancer-associated deaths,underscoring the need for understanding mechanisms that regulate HbV replication and the development of HbV-associated *** is the prototype member of the Hepadnaviridae family;members of this family of viruses have a narrow host range and predominately infect hepatocytes in their respective *** extremely small and compact hepadnaviral genome,the unique arrangement of open reading frames,and a replication strategy utilizing reverse transcription of an RNA intermediate to generate the DNA genome are distinguishing features of the *** this review,the authors provide a comprehensive description of HbV biology,summarize the model systems used for studying HbV infections,and highlight potential mechanisms that link a chronic HbV-infection to the development of *** example,the HbV X protein(Hbx),a key regulatory HbV protein that is important for HbV replication,is thought to play a cofactor role in the development of HbV-induced HCC,and the authors highlight the functions of Hbx that may contribute to the dev

关键词： hepatitis b virus hepatocellular carcinoma hepatitis b virus life cycle hepatitis b virus-associated disease

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