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EFFECTS OF ACUPUNCTURE ON THE IMMUNOLOGICAL FUNCTIONS IN hepatitis b VIRUS CARRIERS

Journal of Traditional Chinese Medicine 1999年第4期19卷 268-272页

作者：陈家福陈民赵斌王英毛树章 The First Municipal Hospital Zhuzhou 412000Hunan Province

A contrast study on the effects of manual acupuncture and electroacupuncture wasconducted in 60 cases of chronic hepatitis b *** results demonstrated that theimmunological functions,both cellular and humoral,were markedly regulated asevidenced by the negative turnover rates of HbsAg,HbeAg,anti-Hbc and HbcAg,as wellas the positive turnover rate of anti-Hbe.

关键词： Acupuncture Therapy Electroacupuncture Adolescent Adult CD4-CD8 Ratio Carrier State Complement C3 Female hepatitis b hepatitis b antibodies hepatitis b Surface Antigens Humans Immunoglobulin A Immunoglobulin G Male

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Prevalence of hepatitis b and C markers among refugees in Athens

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World Journal of Gastroenterology 2003年第5期9卷 993-995页

作者： Anastasios Roussos Constantin Goritsas Thomas Pappas Maria Spanaki Panagiota Papadaki Angeliki Ferti Department of Internal Medicine General Regional Hospital"Sotiria"AthensGreece blood bank General Regional Hospital"Sotiria"AthensGreece

AIM: To assess the prevalence of hepatitis b and C serological markers in a population of refugees living in ***: One hundred and thirty refugees (81 males and 49 females, mean age ±SD: 31.7±8 years) were included in the study. The hepatitis b virus surface antigen (HbsAg),the hepatitis b virus core antibody (anti-Hbc) and the hepatitis C virus antibody (anti-HCV) were detected using a third-generation ***: Twenty individuals (15.4%) were HbsAg positive and 69 (53.1%) were anti-Hbc positive. The prevalence of HbsAg and anti-Hbc was higher among refugees from Albania and Asia (statistical significant difference, P＜0.008 and P＜0.001 respectively). The prevalence of these markers was found irrelevant to age or sex. Anti-HCV was detected in the serum of 3 individuals (2.3 %). No differences among age, sex or ethnicity regarding anti-HCV prevalence were ***: It can be concluded that refugees living in Athens are an immigrant population characterized by a high incidence of HbV infection. The prevalence of HbV markers is higher among refugees from Albania and Asia. It is therefore believed that the adherence to general precautions and the initiation of HbV vaccination programs will be necessary in the future, especially in these *** the prevalence of HCV infection seems to be relatively low, extended epidemiological surveys are needed to provide valid results.

关键词： Refugees Adolescent Adult Aged Albania Asia biological Markers Female Greece hepatitis b hepatitis b antibodies hepatitis b Surface Antigens hepatitis C hepatitis C antibodies Humans Male Middle Aged Seroepidemiologic Studies

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Immunogenicity and reactogenicity of a recombinant hepatitis b vaccine in subjects over age of forty years and response of a booster dose among nonresponders

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World Journal of Gastroenterology 2003年第5期9卷 1132-1134页

作者： Kunal Das R.K.Gupta V.Kumar P.Kar Department of Medicine Maulana Azad Medical College & L.N.HospitalNew Delhi.Medical AdvisorPanacea Biotec Co.New Delhi

AIM:The study was initiated to evaluate the reactogenicity and immunogenicity of a recombinant hepatitis b vaccine in age group >40 years and to study the response of a single booster dose in primary non-responders to the hepatitis b vaccination. METHODS:A total of 102 volunteers without markers of hepatitis b infection (negative for HbsAg,anti-Hbc antibody, HbeAg and anti-Hbs antibody) received 20μg of recombinant Hb vaccine intramuscularly at 0,1,and 6 *** Hbs titers were evaluated by a quantitative Elisa kit at 90 and 210 days.A booster dose of 20μg Hb vaccine was given after 6 months of the 3^(rd) vaccine dose to the 15 non- responders and anti-Hbs titers were measured after i month. RESULTS:Seroprotection (anti-Hbs GMT^3 10 IU/L) was achieved in 85.3 % (87/102) *** mean GMT titers of the vaccine responders was 136.1 IU/*** the seroprotected individuals,there were 32.4% (33/102) hyporesponders (anti- Hbs titers bs titers >100 IU/L).All the non-responders (15/15) responded to a single dose of the booster dose of recombinant Hb vaccine and their mean anti-Hbs antibody titers were more than 100.5 mIU/ml after the booster dose. CONCLUSION:Recombinant hepatitis b vaccine offers good seroprotection in the age group >40 years and has a good safety profile.A single booster dose after 6 months in primary non-responders leads to good seroprotective anti-Hbs antibody ***,larger population based studies are needed to evaluate the role of a booster dose in selected group of non-responders and whether such an approach will be cost effective.

关键词： Adult Age Factors Aged Female hepatitis b antibodies hepatitis b Vaccines dosage Humans Immunization, Secondary Male Middle Aged Safety Vaccines, Synthetic

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正常人与乙型肝炎病毒慢性携带者中乙型肝炎疫苗的血清学效果的观察

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延边大学医学学报 1986年第1期 29-31页

作者：徐龙国朴花顺崔贞玉延边医学院附属医院预防保健科

给61例正常人和33例HbV慢性携带者接种乙肝疫苗,后半年内检测了一些血清学指标。正常人接种疫苗后1,3,6个月时抗—Hbs阳性率分别为27.8％,85.2％和90.1％。HbV携带者接种疫苗后6个月HbsAg滴度上升者8例,下降者4例,仅有1例抗—Hbs阳性,12... 详细信息

给61例正常人和33例HbV慢性携带者接种乙肝疫苗,后半年内检测了一些血清学指标。正常人接种疫苗后1,3,6个月时抗—Hbs阳性率分别为27.8％,85.2％和90.1％。HbV携带者接种疫苗后6个月HbsAg滴度上升者8例,下降者4例,仅有1例抗—Hbs阳性,12例HbeAg阳性者中仅有1例抗—Hbe阳性。所有病例接种疫苗后无明显不良反应。结果说明本疫苗抗原性良好,但对HbsAg携带者无效。

关键词： hepatitis b vaccination carrier state hepatitis b antibodies hepatitis b surface antigen

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