检索结果-南通市图书馆

Prognostic significance of combining high mobility group Box-1 and ov-6 expression in hepatocellular carcinoma

Science China(Life Sciences) 2018年第8期61卷 912-923页

作者： Jihui Zhu Han Yu Shuzhen Chen Pinghua Yang Zihui Dong Yan Ling Hao Tang Shilei Bai Wen Yang Liang Tang Feng Shen Hongyang Wang Wen Wen National Center for Liver Cancer Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China International Cooperation Laboratory on Signal Transduction of Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200433 China Department of hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200433 China Department of Respiratory Medicine Changzheng Hospital Second Military Medical University Shanghai 200003 China Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer Shanghai 200438 China

The inflammatory environment and existence of cancer stem cells are critical for progression and intrahepatic recurrence of hepatocellular carcinoma （HCC） after curative resections. Here, we investigated the prognostic significance of combining high mobility group box 1 （HMGB1） expression and hepatic progenitor marker ov6 in hepatocellular carcinoma. Expression of HMGB 1 and ov6 was evaluated using immunohistochemistry profiling in tissue microarrays containing samples from 208 HCC patients. Invasive clinical or pathological factors were found in patients with high expression of HMGB 1 or ov6. Higher HMGB1 was associated with poorer clinical outcomes, and independently related to elevated 5-year recurrence incidence （85.5% vs. 62.4%, P〈0.001）. We also found that more ov6 positive staining was correlated with poor prognosis of HCC patients （P〈0.001）. Notably, expression of HMGB 1 was positively correlated with ov6 in density （R2=0.032, P〈0.001） and reversely related to HCC outcomes. Abnormal expression of HMGBI in combination with positive staining of ov6 displayed poorer prognostic performance than single biomarker alone （area under curve （AUC） survival=0.696）. Therefore, HMGB 1 and ov6 positive staining are promising prognostic parameters for HCC, and we propose that HMGB1 and ov6 may cooperate with each other and predict poor prognosis of HCC.

关键词： hepatocellular carcinoma high mobility group box 1 hepatic progenitor marker ov6 prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：