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Effect of sitagliptin combined with Yiqi yangyin huoxue decoction on clinical efficacy and hemorheology in early diabetic nephropathy

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世界糖尿病杂志:英文版(电子版) 2023年第9期14卷 1412-1421页

作者： Jun Ling Yan-Hua Yang Department of Pharmacy Changzhou Geriatric Hospital Affiliated to Soochow UniversityChangzhou NO.7 People’s HospitalChangzhou 213000Jiangsu ProvinceChina

BACKGROUND Early diabetic nephropathy(DN)is a complication of diabetes *** mainly affects kidney microvessels and glomerular function,and its timely and effective treatment is critical for early ***,the effects of treatments comprising simple Western medicine are not *** the promotion and implementation of integrated Chinese and western medicine treatments,remarkable results have been achieved for many *** this end,we explored the clinical efficacy of integrated traditional Chinese and western medicines for the treatment of early *** To investigate the effect of sitagliptin tablets combined with Yiqi yangyin huoxue decoction on clinical efficacy and hemorheology in patients with early *** Through a retrospective analysis,123 patients with early DN were admitted to the endocrinology clinic of the Changzhou NO.7 People’s Hospital from January 2021 to October 2022 and were selected as study *** rigorous screening,100 patients with early DN were *** control group(CG,n=50)and the observation group(OG,n=50)were divided according to the treatment *** CG were treated with sitagliptin,and the OG were treated with sitagliptin plus the Yiqi yangyin huoxue *** groups were treated for 3 *** both groups,the baseline data and clinical efficacy were compared,and changes in blood glucose levels,lipid levels,renal function,and hematological indicators before(T0)and after(T1)treatment were *** The total effective rate for the OG was 94.00%and that of the CG was 80.00%(P<0.05).After treatment(T1),the levels of fasting blood glucose,2 h postprandial glucose,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol in OG patients were obviously lower than those in the CG(P<0.05),and cystatin C,homocysteine,urinary microalbumin,and blood creatinine values in OG patients were also obviously lower than those in the CG(P<0.05);erythrocyte deposition,plasma viscosity,whole blood hig

关键词： Sitagliptin Yiqi yangyin huoxue decoction Early diabetic nephropathy Renal function Clinical effects hemorheology

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Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals?

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Journal of Sport and Health Science 2020年第6期9卷 595-603页

作者： Daniel A.Bizjak Fabian Tomschi Gunnar Bales Elie Nader Marc Romana Philippe Connes Wilhelm Bloch Marijke Grau Department of Molecular and Cellular Sports Medicine German Sport University CologneCologne 50933Germany Laboratoire LIBM EA7424-Equipe“Biologie Vasculaire et du Globule Rouge” UniversitéClaude Bernard Lyon 1Villeurbanne 69100France Laboratoire d’Excellence du Globule Rouge GR-Ex Paris 75015France Universitédes Antilles InsermUnitéBiologie Intégrée du Globule RougeCHU de PointeàPitrePointe_a PitreGuadeloupe 97157France Institut Universitaire de France Paris 75231France The German Research Centre of Elite Sport German Sport University CologneCologne 50933Germany

Objective:To examine the impact of a 6-week endurance training on red blood cell(RBC)aging and deformability of healthy participants to detect possible improved hemorheological and performance-related ***:A total of 31 participants(17 females and 14 males)performed a 6-week moderate training protocol(three 1-h running sessions per week at 70%of maximal heart rate).Blood was sampled before and after the *** from each participant were fractioned according to density and age into 4 RBC *** were examined for changes of RBC properties,including aging distribution,RBC deformability,RBC microparticles,and phosphatidylserine *** and plasma nitrite levels were measured as indicators of nitric oxide ***:Aerobic performance,peak oxygen consumption,ventilatory thresholds,velocity at the aerobic-anaerobic threshold,and lactate at exhaustion improved after *** relative amount of both young RBCs and old RBCs increased,and the amount of the main RBC fraction *** externalization and RBC-derived microparticles *** deformability expressed as shear stress required to achieve half-maximum deformation to theoretical maximal elongation index at infinite shear stress improved in unfractioned RBCs(p<0.001).Nitrite decreased in total(p=0.001),young(p<0.001),main(p<0.001),and old(p=0.020)aged RBCs and in plasma(p=0.002),but not in very old ***:These results indicate that non-endurance-trained healthy participants benefit from a regular moderate running training program because performance-related parameters improve and a younger RBC population with improved RBC properties is induced,which might support oxygen supply in the microcirculation.

关键词： Cellular adaptation hemorheology Nitric oxide Performance RBC physiology and aging

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Effect of Liangxuehuayu Recipe on hemorheology in rats with blood stasis syndrome

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Asian Pacific Journal of Tropical Medicine 2012年第12期5卷 935-938页

作者： Song-Yi Ning Biao-Ping Jiang Li Xu Tai-Hui Fang Mian-Hua Wu Nanjing University of Chinese Medicine

Objective:To investigate the effects of Uangxuehuayu Recipe on hemorheology in rats with blood stasis syndrome induced by mutifactor ***:SD rats were divided into control, model,Uangxuehuayu Recipe(high,middle and low dose,18,9,4.S g/kg accordingly).Except the control group,blood stasis model was established in the rest *** hemorheological parameters were measured and ***:Blood viscosity at high,moderate and low level in rats with blood stasis significantly increased(Phemorheology,and has important application value in the prevention of occurrence and development of ischemic stroke.

关键词： Liangxuehuayu Recipe Blood stasis hemorheology SD rats Platelet aggregation rate Defomation ability Aggregation ability Blood viscosity

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Effects of different directions of moxibustion therapy on hemorheology in rats with blood stasis due to cold retention

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Journal of Acupuncture and Tuina Science 2016年第1期14卷 10-15页

作者：王宽呼雪庆黄玉萨王清然高春鹏刘民刘慧荣杨燕萍(译) Shanghai University of Traditional Chinese Medicine Shanghai 201203 China 不详

Objective： To investigate the effects of different directions of moxibustion therapy on hemorheology in rat models with blood stasis due to cold retention. Methods： A total of 32 Wistar rats were randomly divided into 4 groups, based on the random digits table, including a normal group, a model group, a moxibustion along the meridian group, and a moxibustion against the meridian group, with 8 rats in each group. Except the normal group, the other 3 groups were used to make the rat models with blood stasis due to cold retention. Rats in the moxibustion along and against the meridian groups accepted moxibustion therapy in different directions on the trunk segment of the Bladder Meridian after successful modeling. Moxibustion for 10 min every day, and 7 d as a course of treatment. Two courses of treatment（a total of 14 d） were carried out. Quantitative score of signs and symptoms change was observed once a week, with a total of 7 times. Hemorheological indexes of rats were detected when the treatment finished. Results： The quantitative scores of signs and symptoms in the model, moxibustion along the meridian and against the meridian groups were significantly higher than those in the normal group after modeling（P〈0.05）. When the treatment finished, the quantitative score of signs and symptoms in the model group was significantly higher than that in the normal group（P〈0.05）; the quantitative scores of signs and symptoms of rats in the moxibustion along and against the meridian groups were significantly lower than that in the model group（P〈0.05）; the quantitative score of signs and symptoms in the moxibustion along the meridian group was significantly lower than that in the moxibustion against the meridian group（P〈0.05）; the whole blood viscosity and erythrocyte aggregation index in the model group were significantly higher than those in the normal group（P〈0.05）, however the increases of erythrocyte hematocrit and erythrocyte sedimentation rate were not obvious（P〈0.05）; w

关键词： Moxibustion Therapy Bladder Meridian Blood Stasis Due to Coagulated Cold hemorheology Rats

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hemorheology and walking of peripheral arterial occlusive disease patients during treatment with Ginkgo extract

Hemorheology and walking of peripheral arterial occlusive di...

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2000上海科技论坛BIO-X研讨会暨中德医学生物物理和上海流变学研讨会

作者： Li An-lan,Shi Yong-de,Britta Landsmann,Peter Schanowski-Bouvier,Gerhard Dikta,UlrechBauer,Gerhard Michael Artmann(Department of Cell Biophysics,Aachen University of Applied Sciences,D-52428 Juelich,Germany Department of Biophysics,Shanghai Medical University,Shanghai 200032,China,Vascular Disease Center,Lindenstrass 7,53474 Bad Neuenahr-Ahrweiler,Germany)

In peripheral arterial occlusive diseases(PAOD),elevated blood viscosity,increased plasmafibrinogen levels,altered edecyte aggregation and fluidity are related to the severity of *** the treatment of PAOD,the use of vaso-and hemo-rheologically active drugs areconsidered to be a useful therapy,in addition to physical therapy and the elimination of risk *** Ginkgo Biloba extract 761(GbE)from the leaves is one of these *** experimental models ofischemia,edema and hypoxia,GbE reduced vascular,tissular and metabolic abnormalities as well asimpaired blood *** to possible mechanisms of these effects of GbE,antioxidative protection

关键词： Arterial occlusive diseases Ginkgo biloba hemorheology erythrocyte deformation fibrinogen diabetic angiopathies

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Effect of Tongmai Huoxue decoction combined with warm needling on hemorheology and antioxidant capacity in patients with high altitude polycythemia

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Journal of Hainan Medical University 2017年第15期23卷 15-18页

作者： Wen-Ling Zhao Ru-Yi Yang Chang-Xia Cao Zhan-Fang Guo Department of Integrated Traditional Chinese and Western Medicine Affiliated Hospital of Qinghai UniversityXining 810000China

Objective: To investigate the curative effect of Tongmai Huoxue Decoction combined with warm needling on the treatment of High altitude polycythemia (HAPC), and to analyze the changes of hemorheology and antioxidant ability before and after treatment. Methods: A total of 90 HAPC patients were randomly divided into control group and observation group. The control group was treated with low molecular weight dextran and captopril. On the basis of this, the observation group was supplemented with Tongmai Huoxue Decoction combined with warm needling. hemorheology and antioxidant markers were measured before and after treatment in all subjects. Results: Before treatment, there were no significant differences in the hemorheology indexes between the control group and the observation group. After treatment, the two groups of hemorheology related indicators were significantly lower than those before treatment, including whole blood low shear reduction viscosity, whole blood high shear reduction viscosity, plasma viscosity, Hb, Hct and RBC. The levels of the observation group were significantly lower than that of the control group. Before treatment, there was no significant difference in antioxidant indexes between the control group and the observation group. After treatment, the levels of serum superoxide dismutase (SOD) and glutathione (GSH) in the two groups were higher than those in the pre-treatment, while the content of malondialdehyde (MDA) was lower than that before treatment. The levels of serum SOD and GSH in the observation group were higher than those in the control group, and the MDA content was lower than that in the control group. Conclusion: Routine treatment of Western medicine combined with Tongmai Huoxue Decoction joint warm needling method may reduce hemoglobin, improve hemorheology and improve antioxidant ability in HAPC patients, and it may be one of the potential effective drugs for adjuvant therapy of HAPC.

关键词： Tongmai Huoxue Decoction hemorheology Anti-oxidation Warm needling High altitude polycythemia

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The changes of nitric oxide and hemorheology in steroid-induced avas-cular necrosis of femoral head

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Journal of Medical Colleges of PLA(China) 2006年第2期21卷 108-111页

作者：王国毓贺西京李毅张珍妮 Department of Orthopedics Second HospitalXi'an Jiaotong UniversityXi'an 710004China

Objective: To explore the pathogenesis of avascular necrosis of femoral head (ANFH), the early diagnosis index and the treatment effective index of ANFH in clinical practice. Methods: Twenty-four Japanese rabbits were divided into 2 groups: model group and control group. ANFH models were produced by intramuscular injection of large dosage of steroid to rabbits for 8 weeks. On the 4 th, 8 th week after the injection, two rabbits each time from each group were taken to observe the structure of femoral head by light microscope and scanning electron microscope. Four other stomach-empty rabbits from each group were also used to test the contents of Nitric Oxide (NO), contents of the hemorheology indexes. Results: Compared with the control group, the rabbits in the model group exhibited osteoporosis of femoral head and more bone lacuna and more fat cells through light microscope. Through scanning electron microscope observation bone trabecula were broken and sunk, and collagen fibers on the surface of bone matrix became loosen and broken, more osteocyte had pyknosis, adipocyte in the medullary cavity were enlarged and subchondral arterioles and capillaries of the femoral head were pressed by adipocyte. Compared with the control group, the model rabbits contained less NO and obvious increase of the plasma viscosity (PV), low blood viscosity (LBV), erythrocyte hematocrit (HCT), indices of erythrocyte rigidity (TK) and indices of erythrocyte aggregation (AI), plasma fibrin level (PFL) (Phemorheology; and NO and hemorheology should be considered as an early diagnosis index for ANFH in clinical practice.

关键词： femoral head necrosis pathology nitric oxide hemorheology early diagnosis index

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RELATIONSHIP BETWEEN AGE, SEX, AND hemorheology

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Chinese Medical Sciences Journal 2004年第4期19卷 303-303页

作者： Shu-yunZhang YiZhang InstituteofStatistics ZhejiangUniversityHangzhou310028 DepartmentofGerontology HangzhouSanatoriumHangzhou310007

The objective of this study is to investigate the relationship between hemorheology and different sexes and ages,and to provide reference ranges of hemorheology indexes in healthy adults.

关键词： hemorheology Adult Age Factors Aged Aged, 80 and over Blood Sedimentation Blood Viscosity Female Hematocrit Humans Male Middle Aged Sex Factors

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Effects of ethanolic extracts from Radix Morinda officinalis on the hemorheology and platelet aggregation in blood stasis rats

Effects of ethanolic extracts from Radix Morinda officinalis...

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第十五届国际药理学大会

作者： Runfang Fu Guoqing Fengl Shuang Yu Danhui Jia Xiangjie Hu Yongjun Li Department of Pharmacology. Medical College. Zhengzhou University Zhengzhou Henan 450052. Department of Pharmacology. Basic Medical College Zhengzhou University Zhengzhou 450052 China.

＜正＞ Objective: Investigate the influence of ethanolic extracts from Radix Morinda of-ficinalis（ RMO）on the hemorheology and platelet aggregation in acute stress blood stasis rats. Methods: Acute stress blood stasis rats model was prepared by ice water stimulation and the main hemorheological indexes and the rate of platelet aggregation induced by ADP. COL and thrombin were detected. Three different concentrations （12.6.3 g·kg-1） of RMO were before given daily for five days via oral administration. Result: 12,6,3 g·kg-1 treatment of RMO not only significantly reduced the increase of whole blood viscosity at either high, middle or low shear rates, whole blood casson viscosity （P＜0. 01） and Red-cell electrophoresis time （P ＜ 0. 01） but also restrained the rate of platelet aggregation （P ＜0. 01）. In addition. 12.6 g·kg-1 treatment of RMO also decreased the whole blood reduction viscosity in acute stress blood stasis rats （P＜0.01. P＜0.05）. Conclusion: RMO could significantly decrease the dense, viscosity, aggregation and coagulation in blood stasis rats, suggesting that it has the ability of blood-activating and tasis-eliminating.

关键词： RMO blood stasis hemorheology platelet aggregation

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Chronic intermittent hypoxia versus continuous hypoxia:same effects on hemorheology?

Chronic intermittent hypoxia versus continuous hypoxia:same ...

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2015年全国睡眠呼吸学术年会

作者： Jing Kang Yuanyuan Li Ke Hu Wen Lu Xiufang Zhou Shuhui Yu Lifang Xu

Although both chronic intermittent hypoxia（CIH）and chronic continuous hypoxia（CCH）have effects on hemorheology,we do not know whether their roles are the *** this study,we explored the effect of simulated-apneaCIH on hemorheology in experimental rats and compared with the effect of CCH.45adult SD rats were randomly divided into the normoxic control group,CCHand *** rats were given nitrogen and air alternately for 8 hours per day and the experiment lasted for 5 *** control group were placed in the normoxia animal chambers,and the CCH rats were housed in the same chambers which were continuously given normobaric hypoxia（FiO2=10%）.After the preparations,the blood samples were taken andthe hemorheology were *** with control group,the whole blood apparent viscosity,plasma viscosity,hematocrit,erythrocyte aggregation index and electrophoresisindex,platelet aggregation rate and fibrinogensignificantly increased in CIH group and *** whole blood viscosity,plasma viscosity,hematocrit and fibrinogen values were much higher in CCH group than in CIH ***,there was not significantly difference in RBC deformation index or rigidity index among the three groups and no significantly differenceswere found in the effects on RBC rheological property between CIH and *** results suggest that intermittent hypoxia and continuous hypoxia increasewhole blood viscosity,impair the functions of red blood cells and promote the platelet aggregation in model ***,CCH had a greatereffect on blood rheology than CIH.

关键词： chronic intermittent hypoxia continuous hypoxia hemorheology rat.

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