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Human hemotrophic mycoplasmas infection aggravates atherosclerosis in ldlr^(-/-) murine models

South China Journal of Cardiology 2013年第1期14卷 39-47页

作者：邱英 YUN Mark M 韩霞赵瑞东周二霞苏乌云王意忠云升 Inner Mongolia Medical University The First Teaching Hospital UCL Medical School LondonUK Aerospace Medical College Beijing University The Second Medical College Lanzhou University

Hemotrophic mycoplasmas （hemoplasmas） infection is an uncommon zoonosis. The infection in human is rare worldwide, but prevalence in some areas in Inner Mongolia, China reaches 70%-90%. hemoplasmas have been implicated but not proven to be involved in the formation of atherosclerosis. To determine whether there is a causal relationship, the effect of hemoplasmas infection on the development of atherosclerosis was assessed in the low density lipoprotein receptor knockout ldlr-/- mouse. Methods The 4- week-old ldlr-/- mice were inoculated with human hemoplasmas. Atherosclerotic lesions were measured with perfusion staining and aortic root sectioning. The levels of complements were quantified using ELISA. Results Atheroma formation was accelerated over a 26-week period in the infected ldlr-/- mice compared with the uninfected ldlr-/- control mice. The acceleration of atherosclerosis was slowed down by tetracycline administration. Histological analysis of the atheromatous plaques showed larger and thicker lesions in infected mice than in control mice. Membrane attack complex （MAC）, C5b-9, was present in the aortas of the infected mice, which suggests that the pathogen may activate complements and cause inflammation on endothelium, thus accelerate the development of atherosclerosis. Conclusions These data demonstrate that the zoonosis, hemoplasma infection, can accelerate atherosclerotic lesion formation in the ldlr-/- mice. The study provides the first report of a murine model for studying the causative role of hemoplasmas infection in the development of atherosclerosis.

关键词： hemoplasmas infection zoonosis atherosclerosis low density lipoprotein receptor knockout

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