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Circulating Levels of Hypoxia-regulating MicroRNAs in Systemic Lupus Erythematosus Patients with hemolytic anemia

Current Medical Science 2022年第6期42卷 1231-1239页

作者： Amira M.Gamal-Eldeen Cinderella A.Fahmy Bassem M.Raafat Fayez Althobaiti Iman H.Bassyouni Roba M.Talaat Clinical Laboratory Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia High Altitude Research Center Prince Sultan Medical ComplexAl-HawiyahTaif UniversityTaif21944Saudi Arabia Cancer Biology and Genetics Laboratory Centre of Excellence for Advanced SciencesNational Research CentreCairo12622Egypt Biochemistry Department National Research CentreCairo12622Egypt Radiological Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia Biotechnology Department Faculty of ScienceTaif UniversityTaif21944Saudi Arabia Department of Rheumatology and Rehabilitation Faculty of MedicineCairo UniversityEl-Kasr El-Aini HospitalCairo12613Egypt Molecular Biology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)Sadat City UniversitySadat City32897Egypt

Objective MicroRNAs are fine regulators for gene expression during the post-transcriptional stage in many autoimmune ***(miR-210 and miR-21)play an important role in hypoxia and in inflammation-associated *** lupus erythematosus(SLE)is a chronic systemic autoimmune disease that would potentiate many pathological complications,including hemolytic *** study aimed to investigate the role of hypoxamiRs in SLE/hemolytic anemia *** This work was designed to analyze the circulating levels of↱the miR-210 and miR-21 expressions and hypoxia-inducible factor-1α(HIF-α)in SLE/hemolytic anemia *** activity was evaluated for all patients by SLE Disease Activity Index(SLEDAI).Clinical manifestations/complications and serological/hematological investigations were ***-αconcentration was assayed by ELISA and expression of miR-21 and miR-210 was analyzed by *** The results indicated that the fold change of the miR-210/miR-21 expressions in plasma was significantly elevated in SLE/hemolytic anemia patients.A strong positive correlation between the miR-210 and miR-21 expression levels was also *** the associated-disease complications,hypertension,arthritis,oral ulcers,and serositis were associated with a high circulating miR-210 expression,while the occurrence of renal disorders was associated with the increased miR-21 ***,the HIF-αlevel was remarkably elevated in SLE/hemolytic anemia patients.A high positive correlation was recorded between the HIF-αconcentration and miR-210/miR-21 expression *** occurrence of oral ulcers,arthritis,and hypertension was associated with the increased HIF-α*** the other hand,SLEDAI and white blood cell count were positively correlated with miR-21/*** erythrocyte sedimentation rate was positively correlated with *** The dysregulation of the circulating miR-210/miR-210/HIF-1αlevels in SLE/hemolytic anemia pat

关键词： circulating hypoxamiRs miR-210 and miR-21 hypoxia-inducing factor-1α hemolytic anemia systemic lupus erythematosus

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Acute liver failure with hemolytic anemia in children with Wilson’s disease:Genotype-phenotype correlations?

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World Journal of Hepatology 2021年第10期13卷 1428-1438页

作者： Tudor Lucian Pop Alina Grama Ana Cristina Stefanescu Claudia Willheim Peter Ferenci 2^(nd) Pediatric Discipline Department of Mother and ChildIuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 400177Romania 2^(nd) Pediatric Clinic Center of Expertise in Pediatric Liver Rare DisordersEmergency Clinical Hospital for ChildrenCluj-Napoca 400177Romania Department of Internal Medicine Ⅲ Gastroenterology and HepatologyMedical University of ViennaWien A-1090Austria

BACKGROUND Wilson’s disease(WD)is a rare autosomal recessive inherited disorder of copper *** liver failure(ALF)and hemolytic anemia represent the most severe presentation of WD in *** clear genotype-phenotype correlations exist in ***-truncating nonsense,frame-shift,or splice-site variants may be associated with more severe *** contrast,missense variants may be associated with late-onset,less severe disease,and more neurological ***,a gene variant(HSD17B13:TA,rs72613567)with a possible hepatic protective role against toxins was associated with a less severe hepatic phenotype in *** To analyze the possible genotype-phenotype correlations in children with WD presented with ALF and non-immune hemolytic *** The medical records of children with WD diagnosed and treated in our hospital from January 2006 to December 2020 were retrospectively *** clinical manifestations(ALF with non-immune hemolytic anemia or other less severe forms),laboratory parameters,copper metabolism,ATP7B variants,and the HSD17B13:TA(rs72613567)variant were reviewed to analyze the possible genotype-phenotype *** We analyzed the data of 51 patients with WD,26 females(50.98%),with the mean age at the diagnosis of 12.36±3.74 *** and Coombs-negative hemolytic anemia was present in 8 children(15.67%),all adolescent *** Kayser-Fleisher ring was present in 9 children(17.65%).The most frequent variants of the ATP7B gene were ***1069Gln(c.3207A>G)in 38.24% of all alleles,***1341Asp(c.4021G>A)in 26.47%,***939Cys(c.2817G>T)in 9.80%,and ***844Ter(c.2530A>T)in 4.90%.In ALF with hemolytic anemia,***939Cys(c.2817G>T)and ***844Ter(c.2530A>T)variants were more frequent than in other less severe forms,in which ***1069Gln(c.3207A>G)was more ***1341Asp(c.4021G>A)has a similar frequency in all hepatic *** 33 of the patients,the HSD17B13 genotype was *** overall HSD17B13:TA a

关键词： Wilson’s disease Children Acute liver failure hemolytic anemia ATP7B variant Genotype-phenotype correlation

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Clinical analysis of the characteristics of patients diagnosed with hemolytic anemia induced by hepatitis E viral infection

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iLIVER 2022年第2期1卷 117-121页

作者： Haohui Deng Min Xu Huiyuan Liu Hongbo Gao Department of Infectious Disease Center Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina

Background:The extrahepatic manifestations of hepatitis E virus(HEV)infection include hemolytic ***,the clinical characteristics of HEV-induced hemolytic anemia have been only sporadically reported in case reports,and there is a scarcity of relevant systematic *** aim of the current study was to analyze and summarize the clinical characteristics of patients diagnosed with HEV-induced hemolytic ***:This study included 1 patient diagnosed with HEV-induced hemolytic anemia who was admitted to our hospital and 19 additional patients identified through the available ***:Of the 20 patients included in this study,the majorities were from China and India(12 and 6 cases,respectively);furthermore,13 of them were men and 7 were women,with an average age of 35(16–56)*** highest total bilirubin level was 646(452–913)μmol/L,highest alanine aminotransferase level was 1335(708–2798)IU/L,and lowest hemoglobin level was 6.02.0 g/***,10 patients(50.0%,10/20)underwent the glucose-6-phosphate dehydrogenase(G6PD)activity test,and all of them were diagnosed with G6PD deficiency(100.0%,10/10).Finally,18 patients(90.0%)recovered and 2 died(10.0%)after ***:Most of the patients with HEV-induced hemolytic anemia recovered with *** HEV infection that causes hemolytic anemia is strongly associated with the G6PD status of the patients.

关键词： Hepatitis E virus hemolytic anemia Glucose-6-phosphate dehydrogenase

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Exertional heat stroke with pronounced presentation of microangiopathic hemolytic anemia:A case report

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World Journal of Radiology 2024年第10期16卷 545-551页

作者： Chu-Han Xiang Xi-Mu Zhang Jie Liu Jun Xiang Lei Li Qing Song Department of Cardiology The Affiliated Huaihai Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Cardiology The 71st Group Army Hospital of CPLA ArmyXuzhou 221000Jiangsu ProvinceChina Department of Critical Care Medicine Hainan Hospital of Chinese PLA General HospitalSanya 572000Hainan ProvinceChina Department of Emergency Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Emergency The Second Naval Hospital of Southern Theater Command of The People’s Liberation ArmySanya 572022Hainan ProvinceChina Department of Critical Care Medicine Chinese PLA General HospitalBeijing 100853China

BACKGROUND Exertional heat stroke(EHS)is a critical condition arising from prolonged physical exertion in high temperatures that typically presents with normal hemoglobin ***,atypical presentations can also occur,leading to significant complications such as hemolytic anemia and organ *** SUMMARY This case report describes a male patient who experienced moderate-to-severe anemia that was difficult to correct,with a confirmed diagnosis of microangiopathic hemolytic anemia accompanying multiple organ dysfunction syndrome,indicative of critical *** intensive resuscitation efforts,the patient’s condition deteriorated,necessitating admission to the intensive care unit for advanced *** This case highlights the importance of recognizing atypical presentations of EHS,particularly that with significant hemolytic anemia and concurrent organ *** should maintain a high level of suspicion for these complications in patients displaying symptoms of heat-related illness,especially when caused by strenuous activity,as early diagnosis and intervention are crucial to improve patient outcomes.

关键词： Exertional heatstroke hemolytic anemia Microangiopathic hemolytic anemia Multiple organ dysfunction Intensive care unit Case report

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Aqueous Leaf Extract of Moringa oleifera (Moringaceae) Effectively Treats Induced hemolytic anemia in Wistar Rats

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Journal of Biosciences and Medicines 2023年第8期11卷 154-168页

作者： Semado Franck Médard Tchogou Atchadé Pascal Medoatinsa Seinde Espérance Agbogba Félicienne Abissi Yollande Kassa Roxane Lokonon Jacques Ezéchiel Houngbeme Alban Agbonon Amegnon Gbénou Joachim Djimon Baba-Moussa Lamine Senou Maximin Experimental and Clinical Biology Unit (UBEC) Medical and Pharmaceutical Biotechnology Research Laboratory (LaRBiMeP) National School of Applied Biosciences and Biotechnology of Dassa-Zoumé (ENSBBA) National University of Sciences Technologies Engineering and Mathematics of Abomey (UNSTIM) Abomey Benin Experimental and Clinical Biology Unit (UBEC) Medical and Pharmaceutical Biotechnology Research Laboratory (LaRBiMeP) National School of Applied Biosciences and Biotechnology of Dassa-Zoumé (ENSBBA) National University of Sciences Technologies Engineering and Mathematics of Abomey (UNSTIM) Abomey Benin National Pharmacognosy Laboratory (LNP) Institute for Research and Experimentation in Traditional Medicine and Pharmacopoeia (IREMPT) Porto Novo Benin Laboratory of Physiology/Pharmacology Faculty of Sciences University of Lome Lome Togo Doctoral School (ED-STIM) National University of Sciences Technologies Engineering and Mathematics (UNSTIM) Abomey Benin Laboratory of Biology and Molecular Typing in Microbiology University of Abomey-Calavi Cotonou Benin

Introduction: Moringa oleifera was a medicinal plant generally used by populations in the food and therapeutic fields. It’s used to treat anemia has been observed in the Djougou Zone in northern Benin. To our knowledge, there were no scientific data available that have evaluated its efficacy in the treatment of haemolytic anemia. This was what justifies this research work in which the phytochemical analysis, extraction and evaluation of the anti-anemic effect were carried out. Methods: Five groups of five Wistar rats each were formed. All the rats were rendered anemic by injection of phenylhydrazine hydrochloride on the first two days D0 and D1 except those in the negative control group. From the second day, the anemic groups were force-fed either with the aqueous extract of Moringa oleifera leaves at 200 or 300 mg/kg body weight/day, or with vitafer, the reference drug against anemia. The positive control group (anemia) was not treated. Blood samples were taken from all the rats on different days: D0, D2, D7, D10 and D15 to evaluate the data of the hemogram and the osmotic resistance of the red blood cells. Results: Phytochemical analysis revealed the presence of tannins, flavonoids, leucoanthocyanins, saponosides, triterpenes and mucilages. A good yield was obtained at the extraction. Both the extract and the reference drug vitafer completely corrected anemia within two weeks after stimulating hemoglobin synthesis and early release of immature red blood cells into the bloodstream. Its effect seemed dose-dependent and specific. Conclusion: Moringa oleifera leaves showed good therapeutic efficacy and can be considered and exploited for transformation into improved traditional medicines (ITM) in the treatment of anemia.

关键词： Moringa oleifera hemolytic anemia Red Blood Cells Wistar Rats

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Alectinib-Induced Immune hemolytic anemia in a Patient with Lung Adenocarcinoma: Case Report and Literature Review

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Case Reports in Clinical Medicine 2024年第8期13卷 321-327页

作者： Chai Young Lee Yon Ju Ryu Division of Pulmonary and Critical Care Medicine College of Medicine Ewha Womans University Seoul Republic of Korea

Alectinib is a selective Anaplastic Lymphoma Kinase (ALK) tyrosine kinase inhibitor used as standard therapy for ALK-rearranged lung adenocarcinoma. hemolytic anemia is considered a rare but significant adverse event of alectinib. Here, we report the case of a 78-year-old female with advanced ALK rearrangement-positive lung adenocarcinoma who developed grade 4 drug-induced hemolytic anemia after receiving alectinib as first-line therapy. We discontinued alectinib treatment and switched to brigatinib. As a result, anemia improved without recurrence of lung adenocarcinoma over one year.

关键词： Non-Small Cell Lung Cancer Alectinib Brigatinib hemolytic anemia Drug-Induced hemolytic anemia

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Effects of angelica sinensis polysaccharide-iron complex on hemolytic anemia and bone marrow injury in mice

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Journal of Chinese Pharmaceutical Sciences 2008年第3期17卷 197-202页

作者：王珮珮张玉王凯平李珂华中科技大学同济医学院协和医院药剂科湖北武汉430022 华中科技大学同济医学院药学院湖北武汉430030

To investigate the therapeutic effects of angelica sinensis polysaccharide-iron complex （APIC） on hemolytic anemia and bone marrow injury in mice models. The hemolytic anemia mouse model was established by i.p. of phenylhydrazine （PHZ）. Changes of the indices including red blood cell count （RBC）, hemoglobin （Hb） and hematocrit （HCT） were determined by blood analyzer, and reticulocytes were observed by brilliant cresol blue staining during administration. Bone marrow injured mouse model was established by i.p. of cytoxan （CY） and chloramphenicol （CH）, and the therapeutic effect was observed by H-E staining. The indices of APIC treated groups with the medium and high doses were higher than those of the model group significantly. Moreover, the Hb and HCT were restored to the normal level after drug treatments. In addition, APIC can promote the proliferation and differentiation of reticulocytes obviously in the early stage of anemia mice, decrease adipose cell proliferation in bone marrow of injured mice and hasten the recuperation. In conclusion, APIC has therapeutic efficacy on hemolytic anemia and bone marrow injury caused by chemicals, which is reported for the first time.

关键词： Angelica sinensis polysaccharide-iron complex hemolytic anemia Bone marrow injury

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Erythrocytic transglutaminase inhibition hemolysis at presentation of celiac disease

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World Journal of Gastroenterology 2010年第44期16卷 5647-5650页

作者： Petar Ivanovski Dimitrije Nikoli Nikola Dimitrijevi Ivan Ivanovski Vojislav Perii Pediatric Clinic of the University Children's Hospital Medical Faculty University of Belgrade Department of Medical Student Research Medical Faculty University of Belgrade

Celiac disease (CD) is a common autoimmune *** it was considered to be a rare childhood disorder,but is actually considered a relatively common condition,present at any age,which may have multiple complications and *** disorders of the disease are not *** these disorders,the most frequently reported are anemias as a result of iron deficiency,often associated with folate and/or B12 *** caused by hemolysis are very rarely reported in celiac *** 11-year-old girl with a previous uneventful medical history presented with severe hemolytic *** was Coombs negative,accompanied by inappropriate low reticulocyte count,despite exaggerated bone marrow hyperplasia of the erythroid precursors which showed normal *** for recent infections,including EpsteinBarr virus,parvovirus B19,cytomegalovirus and mycoplasma,were all *** of serum IgA,IgG and IgM,were all within normal ranges for *** anti-DNA,antinuclear,antineutrophil cytoplasmic,antimicrosomal,antithyroglobulin,and antimitochondrial antibodies and lupus anticoagulants,was *** was also negative for human immunodeficiency *** therapy with corticosteroids and intravenous immunoglobulin *** was serendipitously discovered upon screening for anti-tissue transglutaminase *** disease was confirmed by biopsy of the small intestine *** patient recovered with gluten-free diet.A unique case of CD is *** should be serologically screened in each patient with Coombs negative "immune"hemolytic anemia,particularly if accompanied by "reticulocytopenia".A new hemolytic mechanism and very speculative explanation for "reticulocytopenia"are discussed.

关键词： Celiac disease Tissue transglutaminase Antibodies hemolytic anemia Gluten free diet

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Glucose 6 phosphatase dehydrogenase (G6PD) and neurodegenerative disorders:Mapping diagnostic and therapeutic opportunities

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Genes & Diseases 2017年第4期4卷 196-203页

作者： Manju Tiwari Department of Biochemistry and Genetics Barkatullah UniversityBhopalMadhya PradeshIndia

Glucose 6 phosphate dehydrogenase(G6PD)is a key and rate limiting enzyme in the pentose phosphate pathway(PPP).The physiological significance of enzyme is providing reduced energy to specific cells like erythrocyte by maintaining co-enzyme nicotinamide adenine dinucleotide phosphate(NADPH).There are preponderance research findings that demonstrate the enzyme(G6PD)role in the energy balance,and it is associated with bloodrelated diseases and disorders,primarily the anemia resulted from G6PD *** Xlinked genetic deficiency of G6PD and associated non-immune hemolytic anemia have been studied widely across the *** advancement in biology,more precisely neuroscience has revealed that G6PD is centrally involved in many neurological and neurodegenerative *** neuroprotective role of the enzyme(G6PD)has also been established,as well as the potential of G6PD in oxidative damage and the Reactive Oxygen Species(ROS)produced in cerebral *** G6PD deficiency remains a global health issue,however,a paradigm shift in research focusing the potential of the enzyme in neurological and neurodegenerative disorders will surely open a new avenue in diagnostics and enzyme ***,in this study,more emphasis was made on exploring the role of G6PD in neurological and inflammatory disorders as well as non-immune hemolytic anemia,thus providing diagnostic and therapeutic opportunities.

关键词： Glucose 6 phosphate dehydrogenase hemolytic anemia Metabolic disorders Neurodegenerative disorders

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Percutaneous closure of paravalvular leak in the treatment of anemia of mixed etiology in a patient with diabetic complications and chronic inflammation

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Journal of Geriatric Cardiology 2016年第10期13卷 866-868页

作者： Magdalena Pelczarska Maciej Lewandowski Jaroslaw Gooracy Andrzej Wojtarowicz Robert Sabiniewicz Grzegorz Wojcik Zdzislawa Komacewicz-Jach Department of Cardiology Pomeranian Medical University in Szczecin Poland Department of Pediatric Cardiology and Congemtal Heart Diseases Medical University in Gdansk Poland The Estabhshment of Clinical Interventions and Disaster Medicine Pomeranian Medical University in Szczecin Poland

hemolytic anemia after implantation of an artificial mitral valve is a rare but recognized complication of surgery. The presence of paravalvular leak after surgery and the necessity of using oral anticoagulants causes... 详细信息

关键词： hemolytic anemia Infective endocarditis Mitral regurgitation Pamvalvular leak

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