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hemolysis of PM_(10) on RBCs in vitro:An indoor air study in a coal-burning lung cancer epidemic area

Geoscience Frontiers 2022年第1期13卷 506-511页

作者： Mengyuan Zhang Longyi Shao Tim Jones Ying Hu Rachel Adams Kelly BéruBé State Key Laboratory of Coal Resources and Safe Mining and College of Geoscience and Surveying EngineeringChina University of Mining&TechnologyBeijing 100083China School of Earth and Environmental Sciences Cardiff UniversityMuseum AvenueCardiff CF103YEUK Guangdong Province Nuclear Industry Geological Bureau Guangzhou 510800China School of Health Sciences Cardiff Metropolitan UniversityLlandaff CampusWestern AvenueCardiff CF52YBWalesUK School of Biosciences Cardiff UniversityMuseum AvenueCardiff CF103AXWalesUK

Epidemiological studies have suggested that inhalation exposure to indoor ambient air from coal-burning environments is causally associated with respiratory health *** order to explore the toxicological mechanisms behind the adverse health effects,the hemolytic activity of PM_(10)(particulate matter with an aerodynamic diameter of 10 um or less)samples collected from homes burning coal in the recognized China"cancer village"Xuanwei were evaluated and matched against their trace elemental *** results demonstrated that the hemolytic activity of indoor PM_(10) in coal-burning environments ranged from 4.28%to 5.24%,with a clear positive dose-response *** low dose samples exhibited a reduced hemolytic activity,PM_(10) could have a toxic effect upon people in a coal-burning indoor environment for extended time *** concentrations of analyzed trace elements in PM_(10) samples ranged from 6966 to 12,958 *** the analyzed elements,Zn,Ti,Ni,Cu,Pb,Ba,Mn,Cr and V were found at higher concentrations and accounted for over 95%of the total *** concentrations of total analyzed elements in the PM_(10) samples revealed a significant positive correlation with PM_(10) hemolytic *** the analyzed elements,Zn,Pb and Cs positively correlated with hemolysis,while Li,U and V negatively correlated with the hemolysis of human red blood cells(RBCs).Therefore,the heavy metal elements could be one of the main factors responsible for the hemolytic capacity of indoor PM_(10) in coal-burning environments.

关键词： Air pollution PM_(10) Coal hemolysis Xuanwei County

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Cytocompatibility and hemolysis of AZ31B Magnesium Alloy with Si-containing Coating

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Journal of Materials Science & Technology 2015年第8期31卷 845-851页

作者： Qiang Wang Lili Tan Ke Yang School of Stomatology China Medical University Institute of Metal Research Chinese Academy of Sciences

In the present study, a Si-containing coating was fabricated on AZ31B Mg alloy. Cytocompatibility of the coated alloy was evaluated by both indirect and direct contact methods, respectively. Effects of a number of incubation variables on the sensitivity and reproducibility of the hemolysis test were also examined by using positively and negatively responding biomaterials. Cytocompatibility testing results indicated that cell condition, cell adherence, cell proliferation and extracellular matrix secretion of the coated alloy were improved compared with those of the uncoated alloy for different extraction and co-culture time. The hemolysis test suggested that hemolysis testing conditions were critical to determine the hemolysis of the alloy. It was also found that 1 day in vitro degradation of the uncoated AZ31B alloy had no destructive effect on erythrocyte. As for the coated AZ31B alloy at any time point, the hemolysis rate was much lower than 5%, the safe value for biomaterials. These in vitro experimental results indicate that the Si-containing coating is effective to improve the cytocompatibility and hemolysis behaviors of AZ31B alloy during its degradation.

关键词： Magnesium alloys Biodegradable Cytocompatibility hemolysis

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Correlation between microbubble-induced acoustic cavitation and hemolysis in vitro

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Chinese Physics B 2011年第2期20卷 316-320页

作者：张春兵刘政郭霞生章东 The Traditional Chinese Medicine Hospital of Jiangsu Province Institute of Acoustics Key Laboratory of Modern Acoustics (Nanjing University)Ministry of EducationNanjing University Xinqiao Hospital Third Military Medical University

Microbubbles promise to enhance the efficiency of ultrasound-mediated drug delivery and gene therapy by taking advantage of artificial cavitation nuclei. The purpose of this study is to examine the ultrasound-induced hemolysis in the application of drug delivery in the presence of microbubbles. To achieve this goal, human red blood cells mixed with microbubbles were exposed to 1-MHz pulsed ultrasound. The hemolysis level was measured by a flow cytometry, and the cavitation dose was detected by a passive cavitation detecting system. The results demonstrate that larger cavitation dose would be generated with the increase of acoustic pressure, which might give rise to the enhancement of hemolysis. Besides the experimental observations, the acoustic pressure dependence of the radial oscillation of microbubble was theoretically estimated. The comparison between the experimental and calculation results indicates that the hemolysis should be highly correlated to the acoustic cavitation.

关键词： acoustic cavitation passive cavitation detection microbubbles hemolysis

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Protective Effects of Resveratrol and its Analogues against Free Radical-Induced Oxidative hemolysis of Red Blood Cells

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Chinese Journal of Chemistry 2002年第11期20卷 1313-1318,1130页

作者：房建国陆曼马兰萍杨立吴隆民刘中立 National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou Gansu 730000 China Email: Zhong-Li Liu (liuzl@***)

The in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of resveratrol (3,5,4′-trihydroxy-trans-stilbene, 1) and its analogues, i.e., 4-hydroxy-trans-stilbene (2), 3,5-dihydroxy-trans-stilbene (3), 3,4-dihydroxy-trans-stilbene (4), 4,4′-dihydroxy-trans-stilbene (5) and 2,4,4′-trihydroxy-trans-stilbene (6). The hemolysis of RBCs was induced by a water-soluble free radical initiator 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH). It was found that addition of AAPH at 37 ℃ to the suspension of RBCs caused fast hemolysis after a short period of inhibition period, and addition of 1-6 significantly suppressed the hemolysis. Compound 4 which bears an ortho-dihydroxyl functionality showed much more effective anti-hemolysis activity than that of resveratrol and the other analogues.

关键词： peroxidation antioxidation resveratrol red blood cell hemolysis

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Antioxidative Effect of Schiff Bases with o-Hydroxybenzylidene Groupon Free Radical Induced hemolysis of Human Red Blood Cell

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Chemical Research in Chinese Universities 2002年第3期18卷 287-289页

作者： LUO Xu yang ZHAO Jian zhang LIN Ying jie LIU Zai qun College of Chemistry Jilin UniversityChangchun 130023P.R.China

The hemolysis of human red blood cells was initiated by a water soluble free radical initiator, 2,2′ azobis (2 amidinopropane hydrochloride)(AAPH), at 37 ℃ in phosphate buffered saline(pH=7.4). The respective addition of 1 [ N (o hydroxybenzylidene)amino]tetradecane(TDCA), 1,2 di[ N (o hydroxybenzylidene)amino]cyclohexane(DACH), 4 [ N (o hydroxybenzylidene)amino]benzoic acid(PABA), 4 nitro[ N (o hydroxybenzylidene)]aniline(APNA) or N (o hydroxybenzylidene)aniline(APA) can all prolong the inhibition period of hemolysis, indicating that the above Schiff bases play an antioxidative role in free radical induced hemolysis. It can be concluded that Schiff base with an alkyl group or a conjugated system in the molecule protect red blood cells against free radical induced hemolysis efficiently. This information may be useful for antioxidant drug design.

关键词： Red blood cell hemolysis Schiff base Free radical

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Evaluation of the hemolysis and fluid dynamics of a ventricular assist device under the pulsatile flow condition

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Journal of Hydrodynamics 2019年第5期31卷 965-975页

作者： Huan Li Zhe Gou Feng Huang Xiao-dong Ruan Wen-wei Qian Xin Fu State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China College of Metrology and Measurement Engineering China Jiliang UniversityHangzhou 310018China Department of Cardio-chest Surgery Zhejiang Provincial Peopled HospitalHangzhou 310014China

When the rotary blood pumps are used as ventricular assist devices,the pump flow rate will have a pulsatile component even at a constant impeller rotational speed due to the remaining beating of the natural ***,previous studies on the in vitro hemolysis evaluation of a rotary blood pump have always been conducted under steady states and this pulsation was not taken into *** this study,the hemolysis in a centrifugal blood pump is evaluated under the pulsatile flow condition in *** required time-varying flow rate is obtained by conducting a system simulation of the pump-assisted cardiovascular system,and realized by controlling a pulsation unit in the *** results of our tests indicate a significant increase in hemolysis under the pulsatile flow condition compared with the non-pulsatile *** reveal the flow characteristics responsible for the higher hemolysis,transient computational fluid dynamic simulations are then *** study suggests that traditional hemolysis evaluation under the steady states may not fully represent the hemolytic performance in the clinical *** the ventricular assist pumps at the design stage,eliminating the concern about the extra hemolysis under the pulsatile condition will be helpful for the subsequent in vivo experiments.

关键词： Ventricular assist devices hemolysis pulsatile flow cardiovascular system numerical simulation

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Dendritic macromolecules as nano-scale drug carriers:Phase solubility,in vitro drug release,hemolysis and cytotoxicity study

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Asian Journal of Pharmaceutical Sciences 2015年第4期10卷 306-313页

作者： Pravinkumar M.Patel Rinkesh Patel Devang Wadia Rajni M.Patel Industrial Chemistry Department V.P.&R.P.T.P.Science CollegeAffiliated to Sardar Patel UniversityVallabh VidhyanagarGujaratIndia Nirlife Healthcare Division Nirma LimitedAhmedabadGujaratIndia P.D.Patel Institute of Pure and Applied Sciences Charusat UniversityChangaGujaratIndia

Potential of nanoscale triazine based dendritic macromolecules G1,G2 and G3 as solubility enhancers of drug was *** of pH,concentration and generation of synthesized dendritic macromolecules on solubility of ketoprofen was studied.G3 dendrimer was further exploited as carrier for sustained *** was encapsulated by inclusion complex method and also characterized by Flourier Transform Infrared *** release study of ketoprofen from ketoprofen loaded dendrimer was carried out and compared with free *** potential and Cytotoxicity assay using A-549 lung cancer cell lines revealed that synthesized triazine based dendritic macromolecules having more potential that commercially available PAMAM dendrimer.

关键词： Triazine based dendrimer Ketoprofen Drug carrier Cytotoxicity hemolysis

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Ribavirin induced hemolysis:A novel mechanism of action against chronic hepatitis C virus infection

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World Journal of Gastroenterology 2014年第43期20卷 16184-16190页

作者： Kaartik Soota Benedict Maliakkal Department of Internal Medicine Unity Health SystemRochesterNY 14626United States Department of Gastroenterology and Hepatology University of Rochester Medical CenterRochesterNY 14642United States

Hepatitis C virus (HCV) is not usually cleared by our immune system, leading to the development of chronic hepatitis C infection. Chronic HCV induces the production of various cytokines, predominantly by Kupffer cells (KCs), and creates a pro-inflammatory state in the liver. The chronic dysregulated production of interferon (IFN) and other cytokines by KCs also promotes innate immune tolerance. Ribavirin (RBV) monotherapy has been shown to decrease inflammation in liver of patients with chronic hepatitis C. Sustained virological response (SVR) is significantly higher when IFN is combined with RBV in chronic HCV (cHCV) infection. However, the mechanism of their synergy remains unclear. Previous theories have attempted to explain the anti-HCV effect based on direct action of RBV alone on the virus or on the immune system; however, these theories have serious shortcomings. We propose that hemolysis, which universally occurs with RBV therapy and which is considered a limiting side effect, is precisely the mechanism by which the anti-HCV effect is exerted. Passive hemolysis results in anti-inflammatory/antiviral actions within the liver that disrupt the innate immune tolerance, leading to the synergy of RBV with IFN-α. Ribavirin-induced hemolysis floods the hepatocytes and KCs with heme, which is metabolized and detoxified by heme oxygenase-1 (HMOX1) to carbon monoxide (CO), biliverdin and free iron (which induces ferritin). These metabolites of heme possess anti-inflammatory and antioxidant properties. Thus, HMOX1 plays an extremely important anti-oxidant, anti-inflammatory and cytoprotective role, particularly in KCs and hepatocytes. HMOX1 has been noted to have anti-viral effects in hepatitis C infected cell lines. Additionally, it has been shown to enhance the response to IFN-α by restoring interferon-stimulated genes (ISGs). This mechanism can be clinically corroborated by the following observations that have been found in patients undergoing RBV/IFN

关键词： Chronic hepatitis C Therapy Ribavirin hemolysis Heme oxygenase-1

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Inhibition of free radical induced oxidative hemolysis of red blood cells by green tea polyphenols

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Chinese Science Bulletin 2000年第22期45卷 2052-2056页

作者： Lanping Ma Zaiqun Liu Bo Zhou Li Yang Zhongli Liu Lanzhou Univ State Key Lab Appl Org Chem Lanzhou 730000 Peoples R China

The in vitro oxidative hemolysis of human red blood cells (RBC) was used as a model to study the free radical induced damage of biological membranes and the inhibitory effect of natural antioxidants. The hemolysis was induced by a water-soluble free radical initiator 2,2’-azo(2-asmidinopropane)dihydrochloride (AAPH) and inhibited by the principal polyphenolic components extracted from green tea leaves, i.e. (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicat-echin gallate (ECG), (-)-epigallocatechin gallate (EGCG) and gallic acid (GA). Addition of AAPH at 37℃ caused fast hemolysis after a short period of inhibition period, while addition of the green tea polyphenols efficiently suppressed the hemolysis in the activity sequence of EGCG > EGC> ECG ≈EC>GA, demonstrating that these green tea polyphenols are effective antioxidants which could protect biological membranes from free radical induced oxidative damage.

关键词： free radical red blood cell hemolysis antioxidant green tea polyphenol.

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Left ventricular assist device hemolysis leading to dysphagia

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World Journal of Gastroenterology 2015年第18期21卷 5735-5738页

作者： Alexander Wuschek Sara Iqbal Jerry Estep Eamonn Quigley David Richards Department of Medicine Division of Gastroenterology Houston Methodist Hospital Houston TX 77030 United States

A 41-year-old man with a continuous- flow left ventricular assist device presented for evaluation of dysphagia and dark urine. He was found to have a significantly elevated L-lactate dehydrogenaseand an elevated plasma free hemoglobin consistent with intravascular *** the hemolysis ceased,both the black urine and dysphagia resolved *** esophageal dysfunction,as a manifestation of gastrointestinal dysmotility,is known to occur in the setting of *** nocturnal hemoglobinuria is another recognized cause of massive hemolysis with gastrointestinal dysmotility occurring in25%-35%of patients during a *** hemolysis increases plasma free hemoglobin,which scavenges nitric oxide(NO),an important second messenger for smooth muscle cell *** decrease in NO can lead to esophageal spasm and resultant *** our patient the resolution of hemolysis resulted in resolution of dysphagia.

关键词： hemolysis dysphagia Esophageal spasm Nitric oxide Left ventricular assist device

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