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Study of capillary transit time distribution in coherent hemodynamics spectroscopy

Journal of Innovative Optical Health Sciences 2015年第2期8卷 78-86页

作者： Angelo Sassaroli Jana Kainerstorfer Sergio Fantini Department of Biomedical Engineering Tufts University 4 Colby StreetMedfordMA 02155USA

A recently proposed analytical hemodynamie modell[***,Neurolmage 85,202-221(2014)]is able to predict the changes of oxy,deoxy,and total hemoglobin concentrations(model outputs)given arbitrary changes in blood flow,blood volume,and rate of oygen consumption(model inputs).One asumption of this model is that the capillary compartment is characterized by a single blood transit *** this work,we have extended the original model by considering a distribution of capillary transit times and we have compared the outputs of both models(original and extended)for the case of sinusoidal input signals at different frequencies,which realizes the new technique of coherent hemodynamics spectroscopy(CHS).For the calculations with the original model,we have used the mean value of the distribution of capillary transit times con-sidered in the extended *** have found that,for distributions of capillary transit times having mean values around 1 s and a standard deviation less than about 45%of the mean value,the original and extended models yield the same CHS spectra(i.e.,model outputs versus fre-quency of ocillation)within typical experimental *** wider capillary transit time dis-tributions,the two models yield different CHS *** assuming that Poiseuille's law is valid in the capillary compartment,we have related the distribution of capillary transit times to the distributions of capillary lengths and capillary speed of blood flow to calculate the average capillary and venous *** have found that,for standard deviations of the capillanry transit time distrilbution that are less than about 80%of the mean value,the average capillary saturation is always larger than the venous *** contrast,the average capillary satu-ration may be less than the venous saturation for wider distributions of the capillary transit times.

关键词： Coherent hemodynamics spectroscopy hermodynamie model near-infrared spectros-copy capillary transit time hemoglobin saturation

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NEAR-INFRARED,BROAD-BAND SPECTRAL IMAGING OF THE HUMAN BREAST FOR QUANTITATIVE OXIMETRY:APPLICATIONS TO HEALTHY AND CANCEROUS BREASTS

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Journal of Innovative Optical Health Sciences 2010年第4期3卷 267-277页

作者： YANG YU ANGELO SASSAROLI DEBBIE K.CHEN MARC J.HOMER ROGER A.GRAHAM SERGIO FANTINI Department of Biomedical Engineering Tufts University 4 Colby StreetMedfordMA 02155USA Tufts Medical Center Department of Radiology 800 Washington StreetBostonMA 02111USA Tufts Medical Center Department of Surgery 800 Washington StreetBostonMA 02111USA

We have examined ten human subjects with a previously developed instrument for near-infrared diffuse spectral imaging of the female *** instrument is based on a tandem,planar scan of two collinear optical fibers(one for illumination and one for collection)to image a gently compressed breast in a transmission *** optical data collection features a spatial sampling of 25 points/cm2 over the whole breast,and a spectral sampling of 2 points/nm in the 650-900nm wavelength *** the ten human subjects examined,eight are healthy subjects and two are cancer patients with unilateral invasive ductal carcinoma and ductal carcinoma in situ,*** each subject,we generate second-derivative images that identify a network of highly absorbing structures in the breast that we assign to blood vessels.A previously developed paired-wavelength spectral method assigns oxygenation values to the absorbing structures displayed in the second-derivative *** resulting oxygenation images feature average values over the whole breast that are significantly lower in cancerous breasts(69±14%,n=2)than in healthy breasts(85±7%,n=18)(p<0.01).Furthermore,in the two patients with breast cancer,the average oxygenation values in the cancerous regions are also significantly lower than in the remainder of the breast(invasive ductal carcinoma:49±11%vs 61±16%,p<0.01;ductal carcinoma in situ:58±8%vs 77±11%,p<0.001).

关键词： Diffuse spectral imaging near-infrared spectroscopy optical mammography oximetry hemoglobin saturation

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Reflectance spectra analysis for mucous assessment

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 822-834页

作者： Toru Chiba Masaharu Murata Takahito Kawano Makoto Hashizume Tomohiko Akahoshi Pentax_LifeCare HOYA CorporationAkishima-shi 196-0012TokyoJapan Center for Advanced Medical Innovation Kyushu UniversityFukuoka-shi 812-8582FukuokaJapan Department of Disaster and Emergency Medicine Graduate School of Medical SciencesKyushu UniversityFukuoka_shi 812-8582FukuokaJapan

This review report represents an overview of research and development on medical hyperspectral imaging technology and its *** imaging technology is attracting attention as a new imaging modality for medical applications,especially in disease diagnosis and image-guided *** the recent advances in imaging,this technology provides an opportunity for twodimensional mapping of oxygen saturation(SatO2)of blood with high accuracy,spatial spectral imaging,and its analysis and provides detection and diagnostic information about the tissue physiology and *** imaging also provides information about tissue oxygenation,perfusion,and potential function during *** algorithm has been examined,and indication of accurate map of relative hemoglobin concentration and SatO2 can be indicated with preferable resolution and frame *** technology is expected to provide promising biomedical information in practical *** studies suggested that blood flow and SatO2 are associated with gastrointestinal disorders,particularly malignant tumor *** use and analysis of spectroscopic images are expected to potentially play a role in the detection and diagnosis of these diseases.

关键词： Diffuse reflectance spectroscopy Endoscopy hemoglobin saturation Hypoxia Gastrointestinal cancer Tumor

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