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The Impact of Finerenone on Changes in Pulse Wave Velocity, Arterial Pressure and Heart Related Deaths in hemodialysis patients—Study Perspective

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Open Journal of Nephrology 2024年第2期14卷 216-225页

作者： Ljiljana Fodor Duric Bozidar Vujicic Tonko Gulin Matko Gulin School of Medicine University Catholica Croatica Zagreb Croatia Department for Nephrology and Arterial Hypertension Medikol Polyclinic Zagreb Croatia Department for Nephrology Dialysis and Kidney Transplantation Clinical Hospital Center Rijeka Faculty of Medicine University of Rijeka Rijeka Croatia Department for Nephrology and Dialysis Clinical Hospital Center Sisters of Charity Zagreb Croatia Faculty of Medicine University of Zagreb Zagreb Croatia Department for Radiology Clinical Hospital Center Sisters of Charity Zagreb Croatia

The description in the abstract lacks clear logic and a comprehensive summary of this study, so please revise and improve it according to the design theme and main content of this study, and describe it in the order of (research background), purpose/aim, method, results and conclusions. The introduction of the abstract and preface is rather lengthy, but the summary of the whole study and the presentation of the research background are not perfect (mainly because the logic of the context is not clear and orderly), so it will appear a bit messy. Hope to be able to modify (this has been mentioned in the preliminary opinion). Cardiovascular events (CVE) pose a significant threat to individuals with end-stage renal disease (ESRD), yet these patients are often excluded from cardiovascular clinical trials, leaving prognostic factors associated with CVE in ESRD patients largely unexplored. Recent human studies have demonstrated elevated circulating aldosterone levels in ESRD patients, correlating with left ventricular hypertrophy. Additionally, animal models have shown improvements in uremic cardiomyopathy with spironolactone therapy, prompting interest in assessing the efficacy of spironolactone or eplerenone in reducing mortality and improving cardiovascular function in dialysis patients. Clinicians have historically been cautious about prescribing mineralocorticoid receptor antagonists (MRAs) to congestive heart failure patients with chronic kidney disease (CKD) due to hyperkalemia risk. However, the emergence of finerenone, a novel MR antagonist with a favorable safety profile and lower hyperkalemia risk, has renewed interest in MRA therapy in this population. Heart disease, including coronary artery disease, hypertension, and left ventricular failure, is alarmingly prevalent in dialysis patients, contributing significantly to elevated mortality rates compared to the general population. Arterial stiffness, as indicated by pulse wave velocity (PWV), progressively worsens

关键词： Cardiovascular Risk Factors Finerenone Arterial Stiffness Heart Related Deaths hemodialysis patients

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Sleep quality in middle-aged and elderly hemodialysis patients:Impact of a structured nursing intervention program

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World Journal of Clinical Cases 2024年第25期12卷 5713-5719页

作者： Ling-Ling Tao Cai-Hua Zeng Wen-Juan Mei Yan-Li Zou Blood Purification Room The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Poor sleep quality is common among hemodialysis patients and can significantly impact their *** study aimed to evaluate the effectiveness of a structured nursing intervention program in improving sleep quality in middleaged and elderly hemodialysis *** To evaluate the impact of nursing intervention on sleep quality in hemodialysis *** This cross-sectional study was conducted in a tertiary hospital,the First Affiliated Hospital of Nanchang University,in *** study included 105 middle-aged and elderly hemodialysis patients aged≥45 years who underwent maintenance hemodialysis for at least 3 mo,utilizing the Pittsburgh Sleep Quality Index(PSQI)to identify poor *** identified underwent a 12-wk nursing intervention program focusing on education,relaxation techniques,and ***-intervention,sleep quality was reassessed using the *** The study found that 68.6%of hemodialysis patients were poor *** the 12-wk nursing intervention program,there was a significant decrease in the mean global PSQI score from 8.9±3.2 to 5.1±2.7(Phemodialysis *** The structured nursing intervention program focusing on sleep hygiene education,relaxation techniques,and counseling effectively improved sleep quality among middle-aged and elderly hemodialysis *** significant decrease in the mean global PSQI score post-intervention indicates the positive impact of tailored nursing interventions in addressing poor sleep quality in this patient *** findings emphasize the importance of implementing targeted nursing interventions to enhance the quality of life for hemodialysis patients by addressing the prevalent issue of poor sleep quality.

关键词： hemodialysis patients Nursing intervention Sleep quality Elderly Pittsburgh Sleep Quality Index Patient wellbeing

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Effects of physical activity by the teach-back educational method on the physical ability and quality of life in hemodialysis patients:a clinical trial

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Frontiers of Nursing 2023年第2期10卷 223-231页

作者： Pegah Sharifian Arash Khalili Morteza Shamsizadeh Neonatal and Pediatric Nursing Department Nursing Care Research Center(NCRC)School of Nursing and MidwiferyIran University of Medical SciencesTehran ***Iran Department of pediatric nursing Mother and Child Care Research CenterHamadan University of Medical SciencesHamadan 65176-19657Iran Department of medical surgical Chronic Diseases(Home Care)Research CenterHamadan University of Medical SciencesHamadan 65176-19657Iran

Objective:To determine the effect of physical activity by using the teach-back educational method on hemodialysis patients’quality of life(QOL)and physical ***:This is a single-blind clinical trial study involving a control group.A total of 90 patients who admitted to the dialysis centers of Beheshti and Besat hospitals in Hamadan were selected using a convenience sampling method and were randomly assigned to intervention(n=45)and control(n=45)*** were collected using a demographic information checklist,a kidney disease QOL questionnaire,and a 6-minute-walk distance(6MWD)*** patients’QOL questionnaire was completed,and the 6MWD was recorded before and at the end of the 2nd,4th,6th,8th,and 12th weeks of the *** the intervention group,the patients were taught to perform physical activities with Pilates stretches in different resistances using the teach-back educational method during dialysis sessions for 12 *** were analyzed by using the independent t-test and chi-square test using SPSS-22 ***:Before the intervention,no differences were observed between the experimental and control groups in terms of demographic characteristics,QOL,and physical ability(P>0.05).The physical ability and QOL levels of patients exercising in the test group were higher than those in the control group after the intervention(Phemodialysis ***,the recommendations and inclusion of exercise in the dialysis care plan can effectively promote patients’health.

关键词： hemodialysis patients physical ability physical activity quality of life teach-back education

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Effect of prayer on the self-care agency and hope in hemodialysis patients

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Journal of Integrative Nursing 2022年第2期4卷 68-75页

作者： Kevser Sevgi Unal ASLAN Funda CETINKAYA Fundamentals of Nursing Department Faculty of Health SciencesOsmaniye Korkut Ata UniversityOsmaniyeTurkey Department of Surgical Nursing Faculty of Health SciencesAksaray UniversityAksarayTurkey

Background:The level of self-care of hemodialysis patients is important in controlling the disease process and *** care has an important place in the process of resolving existing or developing problems of patients receiving hemodialysis treatment and in adapting to *** is not only a resource that encourages religious/spiritual coping,it is also a spirituality that strengthens ***:The objective of this study is to determine whether prayer has an effect on self-care agency and hope in hemodialysis *** and Methods:This is a descriptive and correlational study which was conducted with 180 patients in a private and a public dialysis *** data of 173 hemodialysis patients who met the inclusion criteria were collected using personal information form,Herth Hope Scale,Self-care Agency Scale,and Prayer Attitude ***:A positive,moderate,and statistically significant correlation was found between the Prayer Attitude Scale and total score(r=0.144,P=0.048)and sub-scale future(r=0.350,P=0.000)of Herth Hope *** there was positive correlation between the Prayer Attitude Scale and the total score of Self-care Agency Scale(r=0.599,P=0.000)and its five sub-dimensions drug use(r=0.566,P=0.000),diet(r=0.619,P=0.000),self-monitoring(r=0.522,P=0.000),hygienic care(r=0.576,P=0.000)and mental status(r=0.328,P=0.000).Conclusions:The study found that prayer had a positive effect on self-care agency and hope in hemodialysis patients.

关键词： hemodialysis patients hope prayer self-care

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Prevalence of Metabolic Syndrome and Associated Factors among hemodialysis patients Monitored at the National Teaching Hospital, Hubert Koutoucou Maga in 2015

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Open Journal of Nephrology 2016年第4期6卷 167-175页

作者： Jacques Vigan Adébayo S. C. Alassani Mahoussi M. A. Ahissou Akomola K. Sabi Ubald Assogba-Gbindou Vénérand Attolou François Djrolo Nephrology hemodialysis Department Sylvanus Olympio Teaching Hospital Centre Lomé Togo Nephrology hemodialysis University Clinic of Hubert K Maga Teaching Hospital (CNHU-HKM) Cotonou Benin Endocrinology and Metabolism University Clinic of CNHU-HKM Cotonou Benin Nephrology hemodialysis Department Sylvanus Olympio Teaching Hospital Centre Lomé Togo

Introduction: Metabolic syndrome is one of the main risk factors of cardiovascular disease among hemodialysis patients. Objective: The main objective of this study was to determine the prevalence and factors associated with metabolic syndrome among hemodialysis patients in Cotonou in 2015. patients and methods: It was a cross-sectional, descriptive and analytical study conducted from 05th October to 02nd November 2015 at the National Teaching Hospital, Hubert Koutoucou Maga of Cotonou. All patients aged 18 years and above, regularly under hemodialysis for the past 3 months and who gave their informed consent were included in the study. Those excluded were: currently hospitalized hemodialysis patients, hemodialysis patients hospitalized in the last three months, hemodialysis patients whose general condition deteriorated or unable to answer the questionnaire. Metabolic syndrome was defined according to the International Diabetes Federation’s criteria. Factors associated with metabolic syndrome were sought using logistic regression in univariate analysis. Confidence intervals were calculated at 95% and alpha significance threshold at 5%. Outcomes: In total 165 patients were included in the study. Male predominance was observed, with 1.27 sex-ratios. Average age was 49.3 ± 12.9 years with extremes ranging from 18 to 78 years. Metabolic syndrome is observed among 46 patients undergoing hemodialysis or 27.9% prevalence rate. Factors associated with the metabolic syndrome in univariate analysis were: gender (p 0.001), age (p = 0.007), body mass index (p = 0.029) and prior diabetes history (p = 0.011). Conclusion: Metabolic syndrome is common among hemodialysis patients. Early screening and fighting against associated risk factors are very important.

关键词： Benin Associated Factors hemodialysis patients Prevalence Metabolic Syndrome

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The effects of inhaled aromatherapy on complications of hemodialysis patients: a systematic review

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TMR Integrative Medicine 2020年第23期4卷 1-19页

作者： Xiao-Xiao Yang Yuan-Yuan Chen Fan-Jie Meng Graduate college Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Health Engineering Tianjin University of Traditional Chinese MedicineTianjin 301617China

Objective:To evaluate the effect of inhaled aromatherapy on complications in patients undergoing ***:We search the PubMed,Web of Science,Cochrane Library,Embase and China Biomedical Literature Database from their inception to December,2019 to collect randomized controlled trials about the effects of inhaled aromatherapy on hemodialysis *** screening,data extraction and risk of bias assessment for the included studies were conducted by two reviewers *** summarized all findings with qualitative ***:A total of 15 studies with 967 participants were included in the systematic *** aromatherapy can reduce anxiety,depression,arteriovenous fistula puncture pain,stress and fatigue,and improve the quality of sleep and perceived well-being in hemodialysis ***:Inhaled aromatherapy had certain effects on complications in hemodialysis patients,which can be used as a simple and convenient treatment,but further research was needed to determine standardized implementation procedures and standards.

关键词： Inhalation aromatherapy Randomized controlled trial Systematic review hemodialysis patients

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Transcultural adaptation of Odia version of health-related kidney disease and quality of life-36 instrument

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Journal of Integrative Nursing 2024年第1期6卷 41-48页

作者： Rashmimala PRADHAN Pravati TRIPATHY Debaprasad KAR Department of Medical Surgical Nursing SUM Nursing CollegeSiksha‘O'Anusandhan(Deemed to be University)BhubaneswarOdishaIndia SUM Nursing College Siksha‘O'Anusandhan(Deemed to be University)BhubaneswarOdishaIndia Department of Nephrology IMS and SUM HospitalBhubaneswarOdishaIndia

Objective:The study objective was to translate,validate,and test the reliability of the original kidney disease and quality of life-36(KDQOL-36^(TM))instruments in *** and Methods:A cross-sectional design with a purposive sampling technique was *** to RAND Corporation guidelines,initially,the items of the KDQOL-36^(TM)questionnaires were translated into Odia by two independent,bilingual,professional translators,and then back-translated to English,followed by tryout and field *** experts validated the KDQOL-36^(TM)instrument review committee for review related to kidney health *** tool was implemented among 180 patients undergoing“maintenance”*** following tests evaluated reliability and validity:test-retest reliability with Cronbach’s alpha correlation(stability),(reliability)internal consistency,and contents validity ***:The Cronbach’s alpha value and intraclass correlation coefficient(ICC)score of all five domains,namely“physical component summary,mental component summary(MCS),the burden of kidney disease,symptoms and problems of kidney disease,and effects of kidney disease”of both KDQOL-36^(TM)English and Odia(KDQOL-36-E^(TM)and KDQOL-36-O^(TM))version,recommended excellent homogeneity.A high positive correlation(r=0.998)was found between the Odia version of KDQOL-36^(TM)and the English version KDQOL-36^(TM)*** ICC score ranges from 0.889 to 0.997 at a 95%confidence interval for test-retest reliability,and Cronbach’s alpha was ***:This study explores the Odia version of KDQOL-36^(TM)psychometric properties,depicted at an acceptable level of internal *** KDQOL-36-O^(TM)instrument is a valid and reliable tool for assessing the kidney disease-related quality of life in Odia-speaking hemodialysis patients.

关键词： hemodialysis patients kidney disease and quality of life‑36 reliability transcultural validation

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