检索结果-南通市图书馆

Experience with hemoadsorption (CytoSorb~?) in the management of septic shock patients

World Journal of Critical Care Medicine 2020年第1期9卷 1-12页

作者： Yatin Mehta Chitra Mehta Ashish Kumar Joby Varghese George Aditi Gupta Saurabh Nanda Gourav Kochhar Arun Raizada Medanta The Medicity

BACKGROUND Cytokines and inflammatory mediators are the hallmarks of *** cytokine hemoadsorption devices are the newer clinical support system to overcome the cytokine storm during *** To retrospectively evaluate the clinical outcomes of patients admitted in intensive care unit with septic shock with different *** The laboratory parameters including biomarkers such as procalcitonin,serum lactate and C-reactive protein;and the hemodynamic parameters;mean arterial pressure,vasopressor doses,sepsis scores,cytokine levels and other vital parameters were *** evaluated these outcomes among survivors and *** Of 100 patients evaluated,40 patients *** treatment,the vasopressors dosage remarkably decreased though it was not statistically different;34.15%(P=0.0816)for epinephrine,20.5%for norepinephrine(P=0.3099)and 51%(P=0.0678)for *** the survivor group,a remarkable reduction of biomarkers levels;procalcitonin(65%,P=0.5859),C-reactive protein(27%,P=0.659),serum lactate(27%,P=0.0159)and bilirubin(43.11%;P=0.0565)were observed from baseline after CytoSorb^® therapy.A significant reduction in inflammatory markers;interleukin 6 and interleukin 10;(87%and 92%,P<0.0001)and in tumour necrosis factor(24%,P=0.0003)was also ***,28(28%)patients who were given CytoSorb^® therapy less than 48 h after onset of septic shock survived and the maximum duration of stay for 70%of these patients in intensive care unit was less than 15 *** CytoSorb^® is a safe and well tolerated rescue therapy option in patients with septic ***,early(preferably within<48 h after onset of septic shock)initiation could result in better clinical *** randomized trials are needed to define the potential benefits of this new treatment modality.

关键词： hemoadsorption Sepsis Cytokines Clinical conditions Inflammation and extracorporeal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Systematic review with expert consensus on use of extracorporeal hemoadsorption in septic shock:An Indian perspective

引用

World Journal of Critical Care Medicine 2024年第1期13卷 65-75页

作者： Yatin Mehta Abdul Samad Ansari Amit Kumar Mandal Dipanjan Chatterjee Gauri Shankar Sharma Prachee Sathe Purvesh V Umraniya Rajib Paul Sachin Gupta Vinod Singh Yogendra Pal Singh Institute of Critical Care and Anesthesiology Medanta The MedicityGurgaon 122001HaryanaIndia Department of Critical Care Nanavati Max Super Specialty HospitalMumbai 400065India Department of Pulmonology Sleep and Critical CareFortis HospitalMohaliPunjabMohali 160062PunjabIndia Department of Cardio-Puimonary Critical Care Medica Superspecialty HospitalKolkata 700099India Department of Critical Care Medicine Fortis HospitalNew Delhi 110070India Department of Critical Care Medicine D.Y.Patil Medical CollegeSant Tukaram NagarPimpri ColonyPimpri-ChinchwadPune 411018India Department of Critical Care Medicine Bhailal Amin General HospitalVadodara 390003GujaratIndia Department of Internal Medicine Apollo HospitalsJubilee HillsHyderabad 500033India Department of Anaesthesiology Narayana Superspeciality HospitalGurugram 122002India Department of Critical Care Medicine Institute of Critical Care MedicineHospital Name-Sir Ganga Ram HospitalNew Delhi 110001India Department of Critical Care Medicine Max Super Speciality HospitalDelhi 110092India

BACKGROUND Septic shock is a severe form of sepsis characterised by deterioration in circulatory and cellular-metabolic *** standard therapy,the outcomes are *** adjuvant therapy,such as CytoSorb®extracorporeal haemoadsorption device,has been investigated and shown promising ***,there is a lack of some guidance to make clinical decisions on the use of CytoSorb®haemoadsorption as an adjuvant therapy in septic shock in Indian ***,this expert consensus was *** To formulate/establish specific consensus statements on the use of CytoSorb®haemoadsorption treatment based on the best available evidence and contextualised to the Indian *** We performed a comprehensive literature on CytoSorb®haemoadsorption in sepsis,septic shock in PubMed selecting papers published between January 2011 and March 20232021 in English *** statements for a consensus document were developed based on the summarised literature analysis and identification of knowledge *** a modified Delphi approach combining evidence appraisal and expert opinion,the following topics related to CytoSorb®in septic shock were addressed:need for adjuvant therapy,initiation timeline,need for Interleukin-6 levels,duration of therapy,change of adsorbers,safety,prerequisite condition,efficacy endpoints and management *** expert members from critical care,emergency medicine,and the intensive care participated and voted on nine statements and one open-ended *** Eleven expert members from critical care,emergency medicine,and the intensive care participated and voted on nine statements and one open-ended *** 11 experts in the consensus group(100%)participated in the first,second and third round of *** three iterative voting rounds and adapting two statements,consensus was achieved on nine statements out of nine *** consensus expert panel also recognised the necessity to form an associatio

关键词： Consensus CytoSorb Cytokine hemoadsorption Refractory Sepsis Septic shock

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy of HA330-II column hemoadsorption in Epstein-Barr virusassociated hemophagocytic lymphohistiocytosis combined with liver failure:A case report

引用

World Journal of Hematology 2022年第1期9卷 6-12页

作者： Qian Gao Xiao-Wei Xin Chun Zhao Yu-Juan Wang Wei Wang Yi Yin Xiao-Ru Wang You-Peng Jin Pediatric Intensive Care Unit Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina Pediatric Intensive Care Unit Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a severe and potentially deadly condition associated with extensive inflammation and immune *** adsorption may serve as a supportive treatment that can stabilize organ function in affected patients by reducing their circulating cytokines *** date,no descriptions of clinical experiences associated with the use of HA330-II column hemoadsorption for the treatment of children affected by HLH have been *** SUMMARY We describe the case of an 11-year-old child with Epstein-Barr virus-associated HLH complicated by liver *** underwent HA330-II column hemoadsorption and chemotherapy and exhibited reductions in levels of inflammatory cytokines,including interleukin(IL),IL-6,IL-8,IL-10,and interferon-γ.The patient’s condition and laboratory parameters gradually improved with *** hemoadsorption may play an important role in cytokine storm elimination in children with HLH combined with liver failure and consequent multiple organ failure.

关键词： hemoadsorption HA330-II column Hemophagocytic lymphohistiocytosis Pediatric Liver failure Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preliminary study on the safety and efficacy of a new polymyxin B-immoblized resin column in treatment of LPS-induced sepsis beagles

引用

Animal Models and Experimental Medicine 2022年第2期5卷 161-171页

作者： Yonggui Li Zhenggen Yang Jialiang Hu Zhennan Lin Research and Development Center Guangzhou Koncen Bioscience Co.Ltd.GuangzhouPR China Guangdong Provincial Key Laboratory of hemoadsorption Technology GuangzhouPR China

Background:This study aims to assess the safety and efficacy of direct hemoperfu-sion using a new polymyxin B-immobilized resin column(disposable endotoxin ad-sorber,KCEA)in an endotoxin/lipopolysaccharide(LPS)-induced sepsis ***:Eighteen beagles were randomized into 1 intervention group(KCEA group,n=6)and 2 control groups(sham group and model group,n=6 each).Sepsis was in-duced by continuous intravenous application of 0.5 mg/kg body weight of endotoxin for 60 *** extracorporeal hemoperfusion device made with KCEA for endotoxin adsorption was *** group beagles received standard treatment with fluids and vasoactive drugs,KCEA group beagles received standard treatment and direct hemoperfusion of KCEA for 2 h,and sham group beagles were treated with standard treatment and direct hemoperfusion of a sham column for 2 ***:Good blood compatibility of KCEA was confirmed by assessing clinical *** endotoxin peak levels in the KCEA group were significantly lower,resulting in a significant suppression of IL-6,TNF-αand procalcitonin,which improved mean arterial pressure and significantly lowered vasopressor demand,thereby pro-tecting organ function and improving survival time and *** the KCEA group,MAP was significantly higher over 6 h than those recorded both in the sham group and model *** 7-day survival rates of the KCEA,sham and model groups were 50%,0%and 0%,***:KCEA hemoadsorption was effective at detoxifying circulatory endotoxin and inflammatory mediators and contributed to the decreased mortality rate in the sepsis beagles.

关键词： endotoxin hemoadsorption polymyxin B sulfate resin sepsis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigating Cytokine Binding Using a Previously Reported TNF-Specific Aptamer

引用

Open Journal of Applied Sciences 2012年第3期2卷 135-138页

作者： James D. Fisher Morgan V. DiLeo William J. Federspiel McGowan Institute for Regenerative Medicine University of Pittsburgh Pittsburgh USA

Cytokines are of chief importance in the pathophysiology of sepsis and other systemic inflammatory response syndromes. We are designing and testing an extracorporeal cytokine adsorption device (CAD) that can remove cytokines via adsorption on biocompatible, microporous beads. The goal of this study was to determine whether a previously reported TNF binding DNA aptamer, 5’-GCGGCCGATA AGGTCTTTCC AAGCGAACGA ATTGAACCGC-3’, could be immobilized our hemoadsorption polymer surface to increase the removal rate of TNF. A reservoir consisting of horse serum spiked with a known concentration of TNF was perfused through our CAD packed with aptamer modified or unmodified (control) polymer beads. The binding affinity of the TNF aptamer was characterized using an enzyme-linked oligonucleotide assay (ELONA). As a positive control a well-established DNA aptamer that binds PDGF BB was also subjected to the same ELONA to validate the assay. TNF capture using the CAD showed no TNF removal over four hours for both the aptamer modified and unmodified control beads. Additionally, the results of the ELONA showed no binding of TNF to the reported aptamer;however the PDGF BB aptamer did bind PDGF BB. Based on these results we are able to conclude that the reported TNF specific aptamer does not bind TNF. These results will be of importance to other studies exploring aptamers for specific binding of TNF.

关键词： Aptamers Sepsis hemoadsorption TNF

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：