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KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma

Journal of Genetics and Genomics 2021年第7期48卷 618-630页

作者： Kevin Christian Montecillo Gulay Keisuke Aoshima Yuki Shibata Hironobu Yasui Qin Yan Atsushi Kobayashi Takashi Kimura Laboratory of Comparative Pathology Department of Clinical SciencesFaculty of Veterinary MedicineHokkaido UniversitySapporoHokkaido 060-0818 Japan Laboratory of Radiation Biology Department of Applied Veterinary SciencesFaculty of Veterinary MedicineHokkaido UniversitySapporoHokkaido 060-0818 Japan Department of Pathology Yale School of MedicineNew HavenCT 06510USA

Epigenetic regulators have been implicated in tumorigenesis of many types of cancer;however,their roles in endothelial cell cancers such as canine hemangiosarcoma(HSA)have not been *** this study,we find that lysine-specific demethylase 2 b(KDM2 B)is highly expressed in HSA cell lines compared with normal canine endothelial *** of KDM2 B in HSA cells results in increased cell death in vitro compared with the scramble control by inducing apoptosis through the inactivation of the DNA repair pathways and accumulation of DNA ***,doxycycline-induced KDM2 B silencing in tumor xenografts results in decreased tumor sizes compared with the ***,KDM2 B is also highly expressed in clinical cases of *** hypothesize that pharmacological KDM2 B inhibition can also induce HSA cell death and can be used as an alternative treatment for *** treat HSA cells with GSK-J4,a histone demethylase inhibitor,and find that GSK-J4 treatment also induces apoptosis and cell *** addition,GSK-J4 treatment decreases tumor ***,we demonstrate that KDM2 B acts as an oncogene in HSA by enhancing the DNA damage ***,we show that histone demethylase inhibitor GSK-J4 can be used as a therapeutic alternative to doxorubicin for HSA treatment.

关键词： DNA repair Epigenetics hemangiosarcoma KDM2B Oncogene

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Evaluation of Mast Cells in Dermal versus Subcutaneous Hemangiomas and hemangiosarcomas in Dogs

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Open Journal of Veterinary Medicine 2012年第2期2卷 60-65页

作者： Katherine A. Barber Kim M. Newkirk Ann Reed Robert L. Donnell College of Veterinary Medicine University of Tennessee Knoxville USA Department of Biomedical and Diagnostic Sciences College of Veterinary Medicine University of Tennessee Knoxville USA Research Computing Support Office of Information Technology University of Tennessee Knoxville USA

This study investigated the role of mast cells in canine cutaneous vascular tumors, and is the first such study to distinguish between tumors arising in the dermis versus the subcutis. Mast cell numbers in canine cutaneous hemangiomas (HA) and hemangiosarcomas (HSA) were evaluated to identify a relationship between mast cells, tumor type (HA, HSA), histologic location (dermis, subcutis) and tumor recurrence. One hundred and sixty-seven biopsies from 148 dogs were evaluated. Using only one biopsy from each dog, mast cell counts (MCC) for each tumor (n = 148) were obtained by averaging the number of mast cells counted in ten 400× fields. A significant difference in mean MCC was found only between tumor types, with HA having more mast cells than HSA (4.2 ± 4.2 vs. 2.2 ± 2.6;p < 0.001). No significant difference in mean MCC existed between tumors that recurred and those that did not. There was no difference in recurrence rate between tumor type or histologic location. Our results indicate that benign HA contain more mast cells than malignant endothelial cell tumors, regardless of histologic location;whether this is a cause or effect relationship remains to be determined.

关键词： Canine Dermis Hemangioma hemangiosarcoma Mast Cell Skin Subcutaneous

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Immunohistochemical Evaluation of Vascular Endothelial Growth Factor(VEGF)in Splenic Hemangiomas and hemangiosarcomas in Dogs

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Open Journal of Veterinary Medicine 2012年第4期2卷 191-195页

作者： Andressa Gianotti Campos Juliana Alvares Duarte Bonini Campos Daniel Soares Sanches Maria Lucia Zaidan Dagli Julia Maria Matera Department of Surgery School of Veterinary Medicine and Animal ScienceUniversity of Sao PauloSao PauloBrazil Department of Biostatistics and Scientific Method School of DentistrySao Paulo State UniversityAraraquaraBrazil Department of Animal Pathology School of Veterinary Medicine and Animal ScienceUniversity of Sao PauloSao PauloBrazil

Formation of new blood vessels is paramount for tumour growth and metastatic dissemination and vascular endothelial growth factor (VEGF) is one of the key regulators of this process. The purpose of this study was to evaluate the immunohistochemical expression of VEGF in 23 splenic hemangiosarcomas and 7 splenic hemangiomas in dogs. Blood tests performed previous to splenectomy were analysed for correlation with tumour VEGF expression. Results showed significantly higher VEGF expression in hemangiosarcomas than hemangiomas and lower hematocrit values and red cell count in dogs affected with malignant neoplasia (P hemangiosarcomas.

关键词： Canine Spleen Angiogenesis hemangiosarcoma Immunohistochemistry Vascular Endothelial Growth Factor

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Pancreas-preserving segmental duodenectomy for gastrointestinal stromal tumor of the duodenum and splenectomy for splenic angiosarcoma

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Hepatobiliary & Pancreatic Diseases International 2012年第3期11卷 325-329页

作者： Mirko Muroni Matteo Ravaioli Massimo Del Gaudio Giuseppe Nigri Francesco D'Angelo Stefania Uccini Giovanni Ramacciato Division of Hepato-Biliary-Pancreatic Surgery Department of General Surgery La Sapienza University of Rome Second School of Medicine St. Andrea Hospital Division of Hepato-Biliary-Pancreatic Surgery Department of General Surgery and Department of Clinical and Molecular Medicine La Sapienza University of Rome Second School of Medicine St. Andrea Hospital

BACKGROUND: Gastrointestinal stromal tumors are the most common mesenchymal tumors of the gastrointestinal tract and occur rarely in the duodenum. Splenic angiosarcoma is an aggressive neoplasm with an extremely poor prognosis. METHODS: We report a case of a 70-year-old man hospitalized for abdominal pain in the upper quadrants, dyspepsia and nausea, previously treated for Hodgkin lymphoma 30 years ago. Abdominal CT showed a solid nodular lesion in the third portion of the duodenum, the presence of retropancreatic, aortic and caval lymph nodes, and four nodular splenic masses. 111 In-octreotide scintigraphy revealed pathological tissue accumulation in the duodenal region, and in the retropancreatic, retroduodenal, aortic and caval lymph nodes, suggesting a nonfunctioning neuroendocrine peripancreatic tumor. RESULTS: At exploratory laparotomy, an exophytic soft tumor was found originating from the third portion of the duodenum. Pancreas-preserving duodenectomy with duodenojejunostomy, splenectomy and lymphnodectomy of retropancreatic aortic and caval lymph nodes were performed. Pathological evaluation and immunohistochemical studies showed the presence of a duodenal gastrointestinal stromal tumor with low mitotic activity and a well-differentiated angiosarcoma localized to the spleen and invading lymph ***: We speculated that the angiosarcoma and duodenal gastrointestinal stromal tumors of this patient were due to the treatment of Hodgkin lymphoma with radiotherapy 30 years ago. Pancreas-preserving segmental duodenectomy can be used to treat non-malignant neoplasms of the duodenum and avoid extensive surgery. Splenectomy is the treatment of choice for localized angiosarcomas but a strict follow-up is mandatory because of the possibility of recurrence.

关键词： duodenal neoplasms gastrointestinal stromal tumors hemangiosarcoma splenectomy splenic neoplasms pancreaticoduodenectomy

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Primary hepatic angiosarcoma： A report of two cases andliterature review

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World Journal of Gastroenterology 2015年第19期21卷 6088-6096页

作者： YiPing Zhu YanMin Chen Erik Matro RenBiao Chen ZhiNong Jiang YiPing Mou HongJie Hu ChaoJie Huang GuanYu Wang Yi-Ping Zhu Yi-Ping Mou Guan-Yu Wang Department of General Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310016 Zhejiang Province China.

Primary hepatic angiosarcoma （PHA） is a raremalignancy that carries a poor prognosis. Of 1500patients who underwent hepatectomy for primaryhepatic tumors between 1994 and 2013 at our center,two patients were pathologically diagnosed withPHA. Clinical characteristics, treatment modalities,and outcomes of the two patients were collectedand analyzed. Both patients underwent hepatectomyand had a postoperative survival time of 8 and 16mo, respectively. A search of PubMed yielded eightreferences reporting 35 cases of PHA publishedbetween 2004 and 2013. On the basis of the presentedcases and review of the literature, we endorse completesurgical resection as the mainstay definitive treatmentof PHA, with adjuvant postoperative chemotherapypotentially improving survival. Palliative chemotherapyis an option in advanced hepatic angiosarcoma.

关键词： Diagnosis hemangiosarcoma Therapy Surgery Liver

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