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heat-clearing Chinese Medicines in Lipopolysaccharide-Induced Inflammation

Chinese Journal of Integrative Medicine 2020年第7期26卷 552-559页

作者： LU Zi-bin OU Jin-ying CAO Hui-hui LIU Jun-shan YU Lin-zhong Traditional Chinese Pharmacological Laboratory Third Level Research Laboratory of State Administration of Traditional Chinese MedicineSchool of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou(510515)China

Lipopolysaccharide(LPS)-induced inflammation causes massive threatening diseases,such as sepsis,acute lung injury and multiple organ dysfunction *** treatment to prevent inflammation is crucial in LPS-induced inflammatory ***-clearing Chinese medicines(CMs)have been used to ameliorate LPS-induced inflammation in China for ***-clearing CMs regulate inflammatory pathways,thereby inhibiting the release of inflammatory *** review aimed to introduce promising heat-clearing CMs countering LPS-induced inflammation in the last 5 years,exploring the underlying molecular mechanisms.

关键词： Chinese medicine heat-clearing lipopolysaccharide inflammation review

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Simultaneous determination of chlorogenic acid and baicalin in heat-clearing and detoxicating oral liquid by NIRS

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Health 2009年第3期1卷 134-138页

作者： Zhen-Yao Liu Bing Liu Ji-Dong Yang 不详

The calibration model for simultaneous deter-mination of chlorogenic acid and baicalin in heat-clearing and detoxicating oral liquid was built by partial least squares and near infrared spectroscopy, and the method of spectral pre-treatment was discussed. Building model from calibration set obtained good results, and vali-dated by prediction. According to heat-clearing and detoxicating oral liquid from 30 batches of 6 factories, the correlation coefficient of chloro-genic acid and baicalin model are 0.9993 and 0.9923, The root mean square error of cross validation (RMSECV) are 0.467 and 0.480, and the standard Error of prediction (SEP) of chloro- genic acid and baicalin are 0.356 and 0.370 re-spectively. The correlation coefficients in pre-diction set are 0.9997 and 0.9969, prediction results are accurate and reliable. This method can be applied in rapid analysis of heat- clearing and detoxicating oral liquid, and it is fit for on-line detection and has a wide application prospect.

关键词： Near Infrared Spectroscopy Partial Least Square Method heat-clearing and Detoxicating Oral Liquid Chlorogenic Acid Baicalin

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Antipyretic Effects of Liposoluble Fractions of Viola yedoensis

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Chinese Herbal Medicines 2015年第1期7卷 80-87页

作者： Ying-yi Pan Zhe-ping Song Guo-fu Zhu Yuan-zhang Zhu Yi Lu Wen-long Li Jie Cao Zhi-hong Cheng School of Pharmacy Shanghai University of Traditional Chinese Medicine Department of Pharmacognosy School of Pharmacy Fudan University

Objective To clarify the antipyretic effect of the Chinese materia medica, Violae Herba （Viola yedoensis）, and its active fractions by examining the effects of V. yedoensis extracts with differing polarities on body temperature, total white blood cell （WBC） count, WBC differential count, and total serum complement of rabbits with lipopolysaccharide （LPS）-induced fever. Methods The rabbits were treated with water and ethanolic extracts of V. yedoensis, as well as petroleum ether, ethyl acetate, and n-butanol fractions of the ethanolic extract at low-, mid- and high- doses. The LPS was injected via the ear vein of rabbits in model and treatment groups 30 min post-gavage. Their body temperature was measured at 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, and 6.0 h after the LPS challenge to calculate the temperature changes and thermal response index. After the last temperature measurement, blood samples were collected to determine the blood cell counts and total serum complement （CHs0） level. Results Compared with the model group, body temperature was significantly lower in the low-dose ethanolic extract group, low- and mid-dose petroleum ether fraction groups, and all three ethyl acetate fraction groups. Serum CHs0 levels were lower in all treatment groups, except the ethanolic extract groups, than that in the model group, with no significant difference. V. yedoensis had no significant effect on the blood cells of febrile rabbits challenged with LPS for 6 h. Conclusion The antipyretic effects of V. yedoensis are strong, and its active fractions are the petroleum ether and ethyl acetate fractions of ethanolic extract.

关键词： anti-complement antipyretic effect heat-clearing Viola yedoensis

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Observation on the Therapeutic Effect of heatclearing and Dampness-eliminating Dredging Collaterals Combined with Papaya Antirheumatic Pills on Treatment of Damp-heat Obstructive Ankylosing Spondylitis

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Journal of Clinical and Nursing Research 2020年第2期4卷 57-60页

作者： Youling Huang Xianning Matang Rheumatology Hospital Xianning 437000Hubei ProvincesChina

Objective:Therapeutic effect of heatclearing and dampness-eliminating dredging collaterals combined with papaya antirheumatic pills on treatment of damp-heat obstructive ankylosing ***:A total of 200 patients with ankylosing spondylitis who were treated in our hospital from January 2018 to October 2019 were selected as the research objects and randomly divided into 2 groups,each with 100 *** control group was treated with leflunomide+papaya antirheumatic pills,and the observation group was treated with self-drafted recipe of heat-clearing and dampness-eliminating,the curative effect,visual analogue score(VAS),barthel AS function index(BASFI)score,biochemical indicators and adverse reactions between the two groups were ***:After 12 weeks of treatment,the efficacy of the observation group was higher than that of the control *** pain score,BASFI score,and biochemical index were lower than those of the control group,and the differences were statistically significant(P0.05).Conclusion:heat-clearing and dampnesseliminating dredging collaterals combined with papaya antirheumatic pills is effective in the treatment of damp-heat obstructive ankylosing spondylitis,which is beneficial to reduce the degree of pain and inflammation of the affected area,helps patients remain active,and improves activities of daily living.

关键词： Damp-heat obstructive ankylosing spondylitis heat-clearing and dampness-eliminating dredging collaterals Papaya antirheumatic pills Degree of pain The biochemical index

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丹参的多种临床应用

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中国中西医结合急救杂志 1994年第1期5卷 20-20页

作者：曹元成马英玲山东省淄博市中医院

丹参的多种临床应用曹元成，马英玲丹参，苦能降泄，微寒清热，入心、肝二经血分，而有活血祛瘀、凉血消肿、清心除烦等作用。前人认为丹参能“补血”，而有“一味丹参，功同四物”的说法，其实为祛瘀通经之品，所谓能够“补血”，实为... 详细信息

丹参的多种临床应用曹元成，马英玲丹参，苦能降泄，微寒清热，入心、肝二经血分，而有活血祛瘀、凉血消肿、清心除烦等作用。前人认为丹参能“补血”，而有“一味丹参，功同四物”的说法，其实为祛瘀通经之品，所谓能够“补血”，实为“瘀血法则新血生”之义。在临床上有...

关键词： Prostaglandin Spleen-strensthening and qi-replenishing heat-clearing and detoxifying Endomethacia

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